Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli
Opiates—the gold standard for pain relief—are currently produced by extraction from opium poppies. Here the authors show that bacteria can serve as an efficient and flexible platform for the production of opiates by demonstrating the total synthesis of Thebaine and hydrocodone from stepwise fermenta...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10390 |
| _version_ | 1818841346749759488 |
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| author | Akira Nakagawa Eitaro Matsumura Takashi Koyanagi Takane Katayama Noriaki Kawano Kayo Yoshimatsu Kenji Yamamoto Hidehiko Kumagai Fumihiko Sato Hiromichi Minami |
| author_facet | Akira Nakagawa Eitaro Matsumura Takashi Koyanagi Takane Katayama Noriaki Kawano Kayo Yoshimatsu Kenji Yamamoto Hidehiko Kumagai Fumihiko Sato Hiromichi Minami |
| author_sort | Akira Nakagawa |
| collection | DOAJ |
| description | Opiates—the gold standard for pain relief—are currently produced by extraction from opium poppies. Here the authors show that bacteria can serve as an efficient and flexible platform for the production of opiates by demonstrating the total synthesis of Thebaine and hydrocodone from stepwise fermentation in E. coli. |
| first_indexed | 2024-12-19T04:24:37Z |
| format | Article |
| id | doaj.art-b8e95cfdf252483ab4dd74f7d9237b19 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:24:37Z |
| publishDate | 2016-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b8e95cfdf252483ab4dd74f7d9237b192022-12-21T20:36:04ZengNature PortfolioNature Communications2041-17232016-02-01711810.1038/ncomms10390Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coliAkira Nakagawa0Eitaro Matsumura1Takashi Koyanagi2Takane Katayama3Noriaki Kawano4Kayo Yoshimatsu5Kenji Yamamoto6Hidehiko Kumagai7Fumihiko Sato8Hiromichi Minami9Applied Microbiology laboratory, Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural UniversityApplied Microbiology laboratory, Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural UniversityApplied Microbiology laboratory, Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural UniversityDepartment of Applied Molecular Biology, Graduate School of Biostudies, Kyoto University, Oiwake-cho, KitashirakawaBreeding and Physiology Laboratory, Tsukuba Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and NutritionBreeding and Physiology Laboratory, Tsukuba Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and NutritionApplied Microbiology laboratory, Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural UniversityApplied Microbiology laboratory, Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural UniversityDepartment of Plant Gene and Totipotency, Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Oiwake-cho, KitashirakawaApplied Microbiology laboratory, Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural UniversityOpiates—the gold standard for pain relief—are currently produced by extraction from opium poppies. Here the authors show that bacteria can serve as an efficient and flexible platform for the production of opiates by demonstrating the total synthesis of Thebaine and hydrocodone from stepwise fermentation in E. coli.https://doi.org/10.1038/ncomms10390 |
| spellingShingle | Akira Nakagawa Eitaro Matsumura Takashi Koyanagi Takane Katayama Noriaki Kawano Kayo Yoshimatsu Kenji Yamamoto Hidehiko Kumagai Fumihiko Sato Hiromichi Minami Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli Nature Communications |
| title | Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli |
| title_full | Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli |
| title_fullStr | Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli |
| title_full_unstemmed | Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli |
| title_short | Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli |
| title_sort | total biosynthesis of opiates by stepwise fermentation using engineered escherichia coli |
| url | https://doi.org/10.1038/ncomms10390 |
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