Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease: A Multicentre Study of Geteccu
Background: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of biologics on the risk of PC. Methods: A retrospe...
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Format: | Article |
Language: | English |
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MDPI AG
2021-09-01
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Series: | Journal of Clinical Medicine |
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Online Access: | https://www.mdpi.com/2077-0383/10/19/4402 |
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author | María José García Montserrat Rivero José Miranda-Bautista Iria Bastón-Rey Francisco Mesonero Eduardo Leo-Carnerero Diego Casas-Deza Carmen Cagigas Fernández Albert Martin-Cardona Ismael El Hajra Nerea Hernández-Aretxabaleta Isabel Pérez-Martínez Esteban Fuentes-Valenzuela Nuria Jiménez Cristina Rubín de Célix Ana Gutiérrez Cristina Suárez Ferrer José María Huguet Agnes Fernández-Clotet María González-Vivó Blanca Del Val Jesús Castro-Poceiro Luigi Melcarne Carmen Dueñas Marta Izquierdo David Monfort Abdel Bouhmidi Patricia Ramírez De la Piscina Eva Romero Gema Molina Jaime Zorrilla Cristina Calvino-Suárez Eugenia Sánchez Andrea Nuñez Olivia Sierra Beatriz Castro Yamile Zabana Irene González-Partida Saioa De la Maza Andrés Castaño Rodrigo Nájera-Muñoz Luis Sánchez-Guillén Micaela Riat Castro José Luis Rueda José Manuel Benítez Pedro Delgado-Guillena Carlos Tardillo Elena Peña Santiago Frago-Larramona María Carmen Rodríguez-Grau Rocío Plaza Pablo Pérez-Galindo Jesús Martínez-Cadilla Luis Menchén Manuel Barreiro-De Acosta Rubén Sánchez-Aldehuelo María Dolores De la Cruz Luis Javier Lamuela Ignacio Marín Laura Nieto-García Antonio López-San Román José Manuel Herrera María Chaparro Javier P. Gisbert on behalf of the Young Group of GETECCU |
author_facet | María José García Montserrat Rivero José Miranda-Bautista Iria Bastón-Rey Francisco Mesonero Eduardo Leo-Carnerero Diego Casas-Deza Carmen Cagigas Fernández Albert Martin-Cardona Ismael El Hajra Nerea Hernández-Aretxabaleta Isabel Pérez-Martínez Esteban Fuentes-Valenzuela Nuria Jiménez Cristina Rubín de Célix Ana Gutiérrez Cristina Suárez Ferrer José María Huguet Agnes Fernández-Clotet María González-Vivó Blanca Del Val Jesús Castro-Poceiro Luigi Melcarne Carmen Dueñas Marta Izquierdo David Monfort Abdel Bouhmidi Patricia Ramírez De la Piscina Eva Romero Gema Molina Jaime Zorrilla Cristina Calvino-Suárez Eugenia Sánchez Andrea Nuñez Olivia Sierra Beatriz Castro Yamile Zabana Irene González-Partida Saioa De la Maza Andrés Castaño Rodrigo Nájera-Muñoz Luis Sánchez-Guillén Micaela Riat Castro José Luis Rueda José Manuel Benítez Pedro Delgado-Guillena Carlos Tardillo Elena Peña Santiago Frago-Larramona María Carmen Rodríguez-Grau Rocío Plaza Pablo Pérez-Galindo Jesús Martínez-Cadilla Luis Menchén Manuel Barreiro-De Acosta Rubén Sánchez-Aldehuelo María Dolores De la Cruz Luis Javier Lamuela Ignacio Marín Laura Nieto-García Antonio López-San Román José Manuel Herrera María Chaparro Javier P. Gisbert on behalf of the Young Group of GETECCU |
author_sort | María José García |
collection | DOAJ |
description | Background: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of biologics on the risk of PC. Methods: A retrospective study was performed in 37 centres. Patients treated with biologics within 12 weeks before surgery were considered “exposed”. The impact of the exposure on the risk of 30-day PC and the risk of infections was assessed by logistic regression and propensity score-matched analysis. Results: A total of 1535 surgeries were performed on 1370 patients. Of them, 711 surgeries were conducted in the exposed cohort (584 anti-TNF, 58 vedolizumab and 69 ustekinumab). In the multivariate analysis, male gender (OR: 1.5; 95% CI: 1.2–2.0), urgent surgery (OR: 1.6; 95% CI: 1.2–2.2), laparotomy approach (OR: 1.5; 95% CI: 1.1–1.9) and severe anaemia (OR: 1.8; 95% CI: 1.3–2.6) had higher risk of PC, while academic hospitals had significantly lower risk. Exposure to biologics (either anti-TNF, vedolizumab or ustekinumab) did not increase the risk of PC (OR: 1.2; 95% CI: 0.97–1.58), although it could be a risk factor for postoperative infections (OR 1.5; 95% CI: 1.03–2.27). Conclusions: Preoperative administration of biologics does not seem to be a risk factor for overall PC, although it may be so for postoperative infections. |
first_indexed | 2024-03-10T06:58:15Z |
format | Article |
id | doaj.art-b8ec0ca77d6340f0b35b06cd75226f74 |
institution | Directory Open Access Journal |
issn | 2077-0383 |
language | English |
last_indexed | 2024-03-10T06:58:15Z |
publishDate | 2021-09-01 |
publisher | MDPI AG |
record_format | Article |
series | Journal of Clinical Medicine |
spelling | doaj.art-b8ec0ca77d6340f0b35b06cd75226f742023-11-22T16:18:56ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-011019440210.3390/jcm10194402Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease: A Multicentre Study of GeteccuMaría José García0Montserrat Rivero1José Miranda-Bautista2Iria Bastón-Rey3Francisco Mesonero4Eduardo Leo-Carnerero5Diego Casas-Deza6Carmen Cagigas Fernández7Albert Martin-Cardona8Ismael El Hajra9Nerea Hernández-Aretxabaleta10Isabel Pérez-Martínez11Esteban Fuentes-Valenzuela12Nuria Jiménez13Cristina Rubín de Célix14Ana Gutiérrez15Cristina Suárez Ferrer16José María Huguet17Agnes Fernández-Clotet18María González-Vivó19Blanca Del Val20Jesús Castro-Poceiro21Luigi Melcarne22Carmen Dueñas23Marta Izquierdo24David Monfort25Abdel Bouhmidi26Patricia Ramírez De la Piscina27Eva Romero28Gema Molina29Jaime Zorrilla30Cristina Calvino-Suárez31Eugenia Sánchez32Andrea Nuñez33Olivia Sierra34Beatriz Castro35Yamile Zabana36Irene González-Partida37Saioa De la Maza38Andrés Castaño39Rodrigo Nájera-Muñoz40Luis Sánchez-Guillén41Micaela Riat Castro42José Luis Rueda43José Manuel Benítez44Pedro Delgado-Guillena45Carlos Tardillo46Elena Peña47Santiago Frago-Larramona48María Carmen Rodríguez-Grau49Rocío Plaza50Pablo Pérez-Galindo51Jesús Martínez-Cadilla52Luis Menchén53Manuel Barreiro-De Acosta54Rubén Sánchez-Aldehuelo55María Dolores De la Cruz56Luis Javier Lamuela57Ignacio Marín58Laura Nieto-García59Antonio López-San Román60José Manuel Herrera61María Chaparro62Javier P. Gisbert63on behalf of the Young Group of GETECCUGastroenterology Department, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 37008 Santander, SpainGastroenterology Department, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 37008 Santander, SpainGastroenterology Department, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), and Departamento de Medicina, Universidad Complutense, 28009 Madrid, SpainGastroenterology Department, Hospital Universitario Clínico de Santiago, 15706 Santiago de Compostela, SpainGastroenterology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, SpainGastroenterology Department, Hospital Universitario Virgen del Rocío, 41013 Sevilla, SpainGastroenterology Department, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IISA), 50009 Zaragoza, SpainColorectal Unit, Department of General and Digestive Surgery, Hospital Universitario Marqués de Valdecilla, 39008 Santander, SpainGastroenterology Department, Hospital Universitari Mútua Terrassa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08221 Terrassa, SpainGastroenterology Department, Hospital Universitario Puerta de Hierro, 28220 Majadahonda, SpainGastroenterology Department, Hospital Universitario de Basurto, 48013 Bilbao, SpainDepartment of Gastroenterology, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, SpainGastroenterology Department, Hospital Universitario Río Hortega, 47012 Valladolid, SpainGastroenterology Department, Hospital General Universitario de Elche, 03203 Alicante, SpainGastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, SpainGastroenterology Department, Hospital General de Alicante, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), 03010 Alicante, SpainGastroenterology Department, Hospital Universitario La Paz, 28046 Madrid, SpainGastroenterology Department, Hospital General Universitario de Valencia, 46014 Valencia, SpainGastroenterology Department, Hospital Clinic of Barcelona, 08036 Barcelona, SpainGastroenterology Department, Hospital del Mar, 08003 Barcelona, SpainGastroenterology Department, Hospital Rafael Méndez, 30817 Lorca, SpainGastroenterology Department, Hospital Sant Joan Despí-Moisès Broggi, 08970 Barcelona, SpainGastroenterology Department, Hospital Universitari Parc Taulí, Sabadell, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08208 Barcelona, SpainGastroenterology Department, Hospital Universitario de Cáceres, 10003 Cáceres, SpainGastroenterology Department, Hospital Universitario de Cabueñes, 33203 Gijón, SpainGastroenterology Department, Consorcio Sanitario de Terrasa, 08227 Barcelona, SpainGastroenterology Department, Hospital de Santa Bárbara, 13500 Puertollano, SpainGastroenterology Department, Hospital Universitario Vitoria-Gastéiz, 01002 Vitoria, SpainGastroenterology Department, Hospital Clínico Universitario de Valencia, 46010 Valencia, SpainGastroenterology Department, Hospital Arquitecto Marcide, 15405 Ferrol, SpainDepartment of Colorectal and Gastrointestinal Surgery, Hospital Universitario Gregorio Marañón, 28009 Madrid, SpainGastroenterology Department, Hospital Universitario Clínico de Santiago, 15706 Santiago de Compostela, SpainGastroenterology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, SpainGastroenterology Department, Hospital Universitario Virgen del Rocío, 41013 Sevilla, SpainGastroenterology Department, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IISA), 50009 Zaragoza, SpainGastroenterology Department, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 37008 Santander, SpainGastroenterology Department, Hospital Universitari Mútua Terrassa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08221 Terrassa, SpainGastroenterology Department, Hospital Universitario Puerta de Hierro, 28220 Majadahonda, SpainGastroenterology Department, Hospital Universitario de Basurto, 48013 Bilbao, SpainDepartment of Gastroenterology, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, SpainGastroenterology Department, Hospital Universitario Río Hortega, 47012 Valladolid, SpainDepartment of Colorectal and Gastrointestinal Surgery, Hospital General Universitario de Elche, 03203 Alicante, SpainGastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, SpainGastroenterology Department, Hospital Universitario La Paz, 28046 Madrid, SpainGastroenterology Department, Hospital Reina Sofía, IMIBIC, 14004 Córdoba, SpainGastroenterology Department, Hospital General de Granollers, 08042 Granollers, SpainGastroenterology Department, Hospital Nuestra Señora de la Candelaria, 38010 Tenerife, SpainGastroenterology Department, Hospital Royo Villanova, 50007 Zaragoza, SpainGastroenterology Department, Complejo Hospitalario de Soria, 42005 Soria, SpainGastroenterology Department, Hospital Universitario de Henares, 28002 Coslada, SpainGastroenterology Department, Hospital Universitario Infanta Leonor, Vallecas, 28031 Madrid, SpainGastroenterology Department, Complejo Hospitalario Universitario de Pontevedra, 36071 Pontevedra, SpainGastroenterology Department, Hospital Álvaro Cunqueiro de Vigo, 36312 Vigo, SpainGastroenterology Department, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), and Departamento de Medicina, Universidad Complutense, 28009 Madrid, SpainGastroenterology Department, Hospital Universitario Clínico de Santiago, 15706 Santiago de Compostela, SpainGastroenterology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, SpainGastroenterology Department, Hospital Universitario Virgen del Rocío, 41013 Sevilla, SpainGastroenterology Department, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IISA), 50009 Zaragoza, SpainGastroenterology Department, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), and Departamento de Medicina, Universidad Complutense, 28009 Madrid, SpainGastroenterology Department, Hospital Universitario Clínico de Santiago, 15706 Santiago de Compostela, SpainGastroenterology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, SpainGastroenterology Department, Hospital Universitario Virgen del Rocío, 41013 Sevilla, SpainGastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, SpainGastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, SpainBackground: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of biologics on the risk of PC. Methods: A retrospective study was performed in 37 centres. Patients treated with biologics within 12 weeks before surgery were considered “exposed”. The impact of the exposure on the risk of 30-day PC and the risk of infections was assessed by logistic regression and propensity score-matched analysis. Results: A total of 1535 surgeries were performed on 1370 patients. Of them, 711 surgeries were conducted in the exposed cohort (584 anti-TNF, 58 vedolizumab and 69 ustekinumab). In the multivariate analysis, male gender (OR: 1.5; 95% CI: 1.2–2.0), urgent surgery (OR: 1.6; 95% CI: 1.2–2.2), laparotomy approach (OR: 1.5; 95% CI: 1.1–1.9) and severe anaemia (OR: 1.8; 95% CI: 1.3–2.6) had higher risk of PC, while academic hospitals had significantly lower risk. Exposure to biologics (either anti-TNF, vedolizumab or ustekinumab) did not increase the risk of PC (OR: 1.2; 95% CI: 0.97–1.58), although it could be a risk factor for postoperative infections (OR 1.5; 95% CI: 1.03–2.27). Conclusions: Preoperative administration of biologics does not seem to be a risk factor for overall PC, although it may be so for postoperative infections.https://www.mdpi.com/2077-0383/10/19/4402inflammatory bowel diseaseCrohn’s diseaseulcerative colitisanti-TNFustekinumabvedolizumab |
spellingShingle | María José García Montserrat Rivero José Miranda-Bautista Iria Bastón-Rey Francisco Mesonero Eduardo Leo-Carnerero Diego Casas-Deza Carmen Cagigas Fernández Albert Martin-Cardona Ismael El Hajra Nerea Hernández-Aretxabaleta Isabel Pérez-Martínez Esteban Fuentes-Valenzuela Nuria Jiménez Cristina Rubín de Célix Ana Gutiérrez Cristina Suárez Ferrer José María Huguet Agnes Fernández-Clotet María González-Vivó Blanca Del Val Jesús Castro-Poceiro Luigi Melcarne Carmen Dueñas Marta Izquierdo David Monfort Abdel Bouhmidi Patricia Ramírez De la Piscina Eva Romero Gema Molina Jaime Zorrilla Cristina Calvino-Suárez Eugenia Sánchez Andrea Nuñez Olivia Sierra Beatriz Castro Yamile Zabana Irene González-Partida Saioa De la Maza Andrés Castaño Rodrigo Nájera-Muñoz Luis Sánchez-Guillén Micaela Riat Castro José Luis Rueda José Manuel Benítez Pedro Delgado-Guillena Carlos Tardillo Elena Peña Santiago Frago-Larramona María Carmen Rodríguez-Grau Rocío Plaza Pablo Pérez-Galindo Jesús Martínez-Cadilla Luis Menchén Manuel Barreiro-De Acosta Rubén Sánchez-Aldehuelo María Dolores De la Cruz Luis Javier Lamuela Ignacio Marín Laura Nieto-García Antonio López-San Román José Manuel Herrera María Chaparro Javier P. Gisbert on behalf of the Young Group of GETECCU Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease: A Multicentre Study of Geteccu Journal of Clinical Medicine inflammatory bowel disease Crohn’s disease ulcerative colitis anti-TNF ustekinumab vedolizumab |
title | Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease: A Multicentre Study of Geteccu |
title_full | Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease: A Multicentre Study of Geteccu |
title_fullStr | Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease: A Multicentre Study of Geteccu |
title_full_unstemmed | Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease: A Multicentre Study of Geteccu |
title_short | Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease: A Multicentre Study of Geteccu |
title_sort | impact of biological agents on postsurgical complications in inflammatory bowel disease a multicentre study of geteccu |
topic | inflammatory bowel disease Crohn’s disease ulcerative colitis anti-TNF ustekinumab vedolizumab |
url | https://www.mdpi.com/2077-0383/10/19/4402 |
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