Uncovering impaired mitochondrial and lysosomal function in adipose-derived stem cells from obese individuals with altered biological activity

Uncovering impaired mitochondrial and lysosomal function in adipose-derived stem cells from obese individuals with altered biological activity

Abstract Background Adipose-derived stem cells (ADSCs) have been extensively used in preclinical and clinical trials for treating various diseases. However, the differences between ADSCs from lean individuals (L-ADSCs) and those from obese individuals (O-ADSCs) have not been thoroughly investigated,...

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Bibliographic Details
Main Authors: Bo Wang, Ge Zhang, Yuwen Hu, Ali Mohsin, Zhimin Chen, Weijie Hao, Zhanxia Li, Wei-Qiang Gao, Meijin Guo, Huiming Xu
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Stem Cell Research & Therapy
Subjects:
Adipose-derived stem cells
Obesity
Mitochondrial dysfunction
Lysosomal dysfunction
Online Access:https://doi.org/10.1186/s13287-023-03625-9

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