Acute miliary tuberculosis in pregnancy after in vitro fertilization and embryo transfer: a report of seven cases
Abstract Background While miliary tuberculosis (TB) in pregnancy is rare after in vitro fertilization and embryo transfer (IVF-ET), it poses a serious threat to the health of pregnant women and their fetuses. The present study aimed to describe the clinical features of miliary TB and pregnancy outco...
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-021-06564-z |
| _version_ | 1831543994708918272 |
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| author | Xiaoyan Gai Hongbin Chi Wenli Cao Lin Zeng Lixue Chen Weixia Zhang Donghong Song Ying Wang Ping Liu Rong Li Yongchang Sun |
| author_facet | Xiaoyan Gai Hongbin Chi Wenli Cao Lin Zeng Lixue Chen Weixia Zhang Donghong Song Ying Wang Ping Liu Rong Li Yongchang Sun |
| author_sort | Xiaoyan Gai |
| collection | DOAJ |
| description | Abstract Background While miliary tuberculosis (TB) in pregnancy is rare after in vitro fertilization and embryo transfer (IVF-ET), it poses a serious threat to the health of pregnant women and their fetuses. The present study aimed to describe the clinical features of miliary TB and pregnancy outcomes of patients after IVF-ET. Methods Data of infertile patients who received IVF-ET at Peking University Third Hospital between January 2012 and December 2017 were retrospectively analyzed. Patients who developed miliary TB during pregnancy were identified, and clinical characteristics of miliary TB were described. Results Out of 62,755 infertile women enrolled, 7137 (11.4 %) showed signs of prior pulmonary TB on chest X-ray (CXR). Among the 15,136 women (mean age: 33.2 ± 5.0 years) who successfully achieved clinical pregnancy, seven patients aged 28–35 years had miliary TB during pregnancy, with two patients having a complication of TB meningitis. All these patients presented with fever. Notably, old TB lesions were detected on CXR in six patients before IVF-ET; nevertheless, no anti-TB therapy was administered. Furthermore, salpingography revealed oviduct obstruction in all patients (7/7). Patients received anti-TB therapy following a diagnosis of miliary TB and were clinically cured. However, pregnancy was terminated due to spontaneous (4/7) and induced (3/7) abortion. Conclusions TB reactivation, mostly as miliary TB and TB meningitis, is severe in pregnant women after IVF-ET and deleterious to pregnancy outcomes. Signs of prior TB on CXR may be risk factors for TB reactivation during pregnancy. |
| first_indexed | 2024-12-17T01:00:58Z |
| format | Article |
| id | doaj.art-b8edb942e30d49e6b3c09317a8239dda |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-17T01:00:58Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-b8edb942e30d49e6b3c09317a8239dda2022-12-21T22:09:26ZengBMCBMC Infectious Diseases1471-23342021-09-012111910.1186/s12879-021-06564-zAcute miliary tuberculosis in pregnancy after in vitro fertilization and embryo transfer: a report of seven casesXiaoyan Gai0Hongbin Chi1Wenli Cao2Lin Zeng3Lixue Chen4Weixia Zhang5Donghong Song6Ying Wang7Ping Liu8Rong Li9Yongchang Sun10Department of Respiratory and Critical Care Medicine, Peking University Third HospitalCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalTuberculosis Department, Beijing Geriatric HospitalClinical Epidemiology Research Center, Peking University Third HospitalCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalDepartment of Respiratory and Critical Care Medicine, Peking University Third HospitalCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third HospitalDepartment of Respiratory and Critical Care Medicine, Peking University Third HospitalAbstract Background While miliary tuberculosis (TB) in pregnancy is rare after in vitro fertilization and embryo transfer (IVF-ET), it poses a serious threat to the health of pregnant women and their fetuses. The present study aimed to describe the clinical features of miliary TB and pregnancy outcomes of patients after IVF-ET. Methods Data of infertile patients who received IVF-ET at Peking University Third Hospital between January 2012 and December 2017 were retrospectively analyzed. Patients who developed miliary TB during pregnancy were identified, and clinical characteristics of miliary TB were described. Results Out of 62,755 infertile women enrolled, 7137 (11.4 %) showed signs of prior pulmonary TB on chest X-ray (CXR). Among the 15,136 women (mean age: 33.2 ± 5.0 years) who successfully achieved clinical pregnancy, seven patients aged 28–35 years had miliary TB during pregnancy, with two patients having a complication of TB meningitis. All these patients presented with fever. Notably, old TB lesions were detected on CXR in six patients before IVF-ET; nevertheless, no anti-TB therapy was administered. Furthermore, salpingography revealed oviduct obstruction in all patients (7/7). Patients received anti-TB therapy following a diagnosis of miliary TB and were clinically cured. However, pregnancy was terminated due to spontaneous (4/7) and induced (3/7) abortion. Conclusions TB reactivation, mostly as miliary TB and TB meningitis, is severe in pregnant women after IVF-ET and deleterious to pregnancy outcomes. Signs of prior TB on CXR may be risk factors for TB reactivation during pregnancy.https://doi.org/10.1186/s12879-021-06564-zMiliary tuberculosisInfertilityIn vitro fertilizationEmbryo transfer |
| spellingShingle | Xiaoyan Gai Hongbin Chi Wenli Cao Lin Zeng Lixue Chen Weixia Zhang Donghong Song Ying Wang Ping Liu Rong Li Yongchang Sun Acute miliary tuberculosis in pregnancy after in vitro fertilization and embryo transfer: a report of seven cases BMC Infectious Diseases Miliary tuberculosis Infertility In vitro fertilization Embryo transfer |
| title | Acute miliary tuberculosis in pregnancy after in vitro fertilization and embryo transfer: a report of seven cases |
| title_full | Acute miliary tuberculosis in pregnancy after in vitro fertilization and embryo transfer: a report of seven cases |
| title_fullStr | Acute miliary tuberculosis in pregnancy after in vitro fertilization and embryo transfer: a report of seven cases |
| title_full_unstemmed | Acute miliary tuberculosis in pregnancy after in vitro fertilization and embryo transfer: a report of seven cases |
| title_short | Acute miliary tuberculosis in pregnancy after in vitro fertilization and embryo transfer: a report of seven cases |
| title_sort | acute miliary tuberculosis in pregnancy after in vitro fertilization and embryo transfer a report of seven cases |
| topic | Miliary tuberculosis Infertility In vitro fertilization Embryo transfer |
| url | https://doi.org/10.1186/s12879-021-06564-z |
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