The minimum volume of pleural fluid required to diagnose malignant pleural effusion: A retrospective study
Background: Pleural fluid cytology is a quick and accurate method to diagnose malignant pleural effusions. The optimal volume of fluid for cytological analysis has not yet been identified, and clinical recommendation based on some published clinical experiences has been to send large volumes of flui...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2017-01-01
|
| Series: | Lung India |
| Subjects: | |
| Online Access: | http://www.lungindia.com/article.asp?issn=0970-2113;year=2017;volume=34;issue=1;spage=34;epage=37;aulast=Wu |
| _version_ | 1818601444692983808 |
|---|---|
| author | Huimin Wu Rahul Khosla Prashant K Rohatgi Suman S Chauhan Edina Paal Wen Chen |
| author_facet | Huimin Wu Rahul Khosla Prashant K Rohatgi Suman S Chauhan Edina Paal Wen Chen |
| author_sort | Huimin Wu |
| collection | DOAJ |
| description | Background: Pleural fluid cytology is a quick and accurate method to diagnose malignant pleural effusions. The optimal volume of fluid for cytological analysis has not yet been identified, and clinical recommendation based on some published clinical experiences has been to send large volumes of fluid for cytological analysis. A quality improvement initiative at our institution was conducted to determine the volume of fluid sufficient for a diagnosis of malignant pleural effusion. Materials and Methods: The study was approved by the Institutional Review Board. All pleural fluid specimens that were divided into three volumes (25 mL, 50 mL, and 150 mL) and sent for cytological examination were reviewed. Results: A total of 74 samples from 60 individual patients were evaluable. Thirty-six patients (60%) had a previous diagnosis of malignancy. Of the 74 specimens, 26 (35.1%) were positive for malignancy. The detection rate for malignant pleural effusion by cytology for 25 mL, 50 mL, and 150 mL were 88.5%, 96.2%, and 100.0%, respectively (P = 0.16). Two specimens that were negative in the 25 mL samples turned out to be positive in the 50 mL and 150 mL samples. One specimen was negative in the 25 mL and 50 mL samples but positive in the 150 mL sample. Conclusions: Our study did not show any statistically significant difference in the detection of malignant effusion in the 25 mL, 50 mL, and 150 mL group. |
| first_indexed | 2024-12-16T12:51:29Z |
| format | Article |
| id | doaj.art-b8ef5c8b069f418eae378d6b565d2d7f |
| institution | Directory Open Access Journal |
| issn | 0970-2113 0974-598X |
| language | English |
| last_indexed | 2024-12-16T12:51:29Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Lung India |
| spelling | doaj.art-b8ef5c8b069f418eae378d6b565d2d7f2022-12-21T22:31:08ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2017-01-01341343710.4103/0970-2113.197120The minimum volume of pleural fluid required to diagnose malignant pleural effusion: A retrospective studyHuimin WuRahul KhoslaPrashant K RohatgiSuman S ChauhanEdina PaalWen ChenBackground: Pleural fluid cytology is a quick and accurate method to diagnose malignant pleural effusions. The optimal volume of fluid for cytological analysis has not yet been identified, and clinical recommendation based on some published clinical experiences has been to send large volumes of fluid for cytological analysis. A quality improvement initiative at our institution was conducted to determine the volume of fluid sufficient for a diagnosis of malignant pleural effusion. Materials and Methods: The study was approved by the Institutional Review Board. All pleural fluid specimens that were divided into three volumes (25 mL, 50 mL, and 150 mL) and sent for cytological examination were reviewed. Results: A total of 74 samples from 60 individual patients were evaluable. Thirty-six patients (60%) had a previous diagnosis of malignancy. Of the 74 specimens, 26 (35.1%) were positive for malignancy. The detection rate for malignant pleural effusion by cytology for 25 mL, 50 mL, and 150 mL were 88.5%, 96.2%, and 100.0%, respectively (P = 0.16). Two specimens that were negative in the 25 mL samples turned out to be positive in the 50 mL and 150 mL samples. One specimen was negative in the 25 mL and 50 mL samples but positive in the 150 mL sample. Conclusions: Our study did not show any statistically significant difference in the detection of malignant effusion in the 25 mL, 50 mL, and 150 mL group.http://www.lungindia.com/article.asp?issn=0970-2113;year=2017;volume=34;issue=1;spage=34;epage=37;aulast=WuCytologymalignantpleural effusion |
| spellingShingle | Huimin Wu Rahul Khosla Prashant K Rohatgi Suman S Chauhan Edina Paal Wen Chen The minimum volume of pleural fluid required to diagnose malignant pleural effusion: A retrospective study Lung India Cytology malignant pleural effusion |
| title | The minimum volume of pleural fluid required to diagnose malignant pleural effusion: A retrospective study |
| title_full | The minimum volume of pleural fluid required to diagnose malignant pleural effusion: A retrospective study |
| title_fullStr | The minimum volume of pleural fluid required to diagnose malignant pleural effusion: A retrospective study |
| title_full_unstemmed | The minimum volume of pleural fluid required to diagnose malignant pleural effusion: A retrospective study |
| title_short | The minimum volume of pleural fluid required to diagnose malignant pleural effusion: A retrospective study |
| title_sort | minimum volume of pleural fluid required to diagnose malignant pleural effusion a retrospective study |
| topic | Cytology malignant pleural effusion |
| url | http://www.lungindia.com/article.asp?issn=0970-2113;year=2017;volume=34;issue=1;spage=34;epage=37;aulast=Wu |
| work_keys_str_mv | AT huiminwu theminimumvolumeofpleuralfluidrequiredtodiagnosemalignantpleuraleffusionaretrospectivestudy AT rahulkhosla theminimumvolumeofpleuralfluidrequiredtodiagnosemalignantpleuraleffusionaretrospectivestudy AT prashantkrohatgi theminimumvolumeofpleuralfluidrequiredtodiagnosemalignantpleuraleffusionaretrospectivestudy AT sumanschauhan theminimumvolumeofpleuralfluidrequiredtodiagnosemalignantpleuraleffusionaretrospectivestudy AT edinapaal theminimumvolumeofpleuralfluidrequiredtodiagnosemalignantpleuraleffusionaretrospectivestudy AT wenchen theminimumvolumeofpleuralfluidrequiredtodiagnosemalignantpleuraleffusionaretrospectivestudy AT huiminwu minimumvolumeofpleuralfluidrequiredtodiagnosemalignantpleuraleffusionaretrospectivestudy AT rahulkhosla minimumvolumeofpleuralfluidrequiredtodiagnosemalignantpleuraleffusionaretrospectivestudy AT prashantkrohatgi minimumvolumeofpleuralfluidrequiredtodiagnosemalignantpleuraleffusionaretrospectivestudy AT sumanschauhan minimumvolumeofpleuralfluidrequiredtodiagnosemalignantpleuraleffusionaretrospectivestudy AT edinapaal minimumvolumeofpleuralfluidrequiredtodiagnosemalignantpleuraleffusionaretrospectivestudy AT wenchen minimumvolumeofpleuralfluidrequiredtodiagnosemalignantpleuraleffusionaretrospectivestudy |