Alkaline phosphatase LapA regulates quorum sensing–mediated virulence and biofilm formation in Pseudomonas aeruginosa PAO1 under phosphate depletion stress

Alkaline phosphatase LapA regulates quorum sensing–mediated virulence and biofilm formation in Pseudomonas aeruginosa PAO1 under phosphate depletion stress

ABSTRACT Among various environmental stresses, the depletion of inorganic phosphate, which is an important signaling molecule that modulates virulence production, is notable. In our previous study, we demonstrated that lapA, encoding alkaline phosphatase, plays a key role in Pseudomonas aeruginosa b...

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Bibliographic Details
Main Authors: Xiaojuan Tan, Xi Cheng, Jingjing Xiao, Qianqian Liu, Dongsheng Du, Minghui Li, Yang Sun, Jinwei Zhou, Guoping Zhu
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:Microbiology Spectrum
Subjects:
Pseudomonas aeruginosa
alkaline phosphatase LapA
virulence
biofilms
chronic wound infection
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02060-23

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