Analysis of Flavonoids Bioactivity for Cholestatic Liver Disease: Systematic Literature Search and Experimental Approaches

Flavonoids are naturally occurring compounds that show health benefits on the liver. However, there is little investigation about identification and evaluation of new flavonoid-containing drugs for cholestatic liver disease, one of the most common liver illnesses. We aimed to a systematic search reg...

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Main Authors: Juan Carlos Sánchez-Salgado, Samuel Estrada-Soto, Sara García-Jiménez, Sergio Montes, Jaime Gómez-Zamudio, Rafael Villalobos-Molina
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Biomolecules
Subjects:
Online Access:http://www.mdpi.com/2218-273X/9/3/102
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author Juan Carlos Sánchez-Salgado
Samuel Estrada-Soto
Sara García-Jiménez
Sergio Montes
Jaime Gómez-Zamudio
Rafael Villalobos-Molina
author_facet Juan Carlos Sánchez-Salgado
Samuel Estrada-Soto
Sara García-Jiménez
Sergio Montes
Jaime Gómez-Zamudio
Rafael Villalobos-Molina
author_sort Juan Carlos Sánchez-Salgado
collection DOAJ
description Flavonoids are naturally occurring compounds that show health benefits on the liver. However, there is little investigation about identification and evaluation of new flavonoid-containing drugs for cholestatic liver disease, one of the most common liver illnesses. We aimed to a systematic search regarding efficacy of flavonoids for treatment of cholestatic liver disease, and then evaluate naringenin (NG) as representative flavonoid in an obstructive cholestasis model. We searched for information of experimental and clinical studies in four major databases without time and language limits. Intervention was defined as any flavonoid derivate compared with other flavonoid, placebo, or without comparator. In addition, we evaluated NG on a bile duct-ligated model in order to contribute evidence of its actions. Eleven experimental reports that support the efficacy of flavonoids in cholestatic liver disease were identified. However, there was no homogeneity in efficacy endpoints evaluated and methodology. On the other hand, NG showed beneficial effects by improving specific metabolic (cholesterol and lipoproteins) and liver damage (bilirubin and alkaline phosphatase) biomarkers. The review lacks homogeneous evidence about efficacy of flavonoids in experimental settings, and is susceptible to risk for bias. NG only showed improvements in specific disease biomarkers. More investigation is still needed to determine its potential for drug development.
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spelling doaj.art-b8efee476f644d2b80db346bf3268d232022-12-21T18:22:05ZengMDPI AGBiomolecules2218-273X2019-03-019310210.3390/biom9030102biom9030102Analysis of Flavonoids Bioactivity for Cholestatic Liver Disease: Systematic Literature Search and Experimental ApproachesJuan Carlos Sánchez-Salgado0Samuel Estrada-Soto1Sara García-Jiménez2Sergio Montes3Jaime Gómez-Zamudio4Rafael Villalobos-Molina5Instituto de Medicina Molecular y Ciencias Avanzadas, Mexico City 01900, MexicoFacultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, MOR 62209, MexicoFacultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, MOR 62209, MexicoInstituto Nacional de Neurología y Neurocirugía, Mexico City 14269, MexicoUnidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS, México City 06720, MexicoUnidad de Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla 54090, MexicoFlavonoids are naturally occurring compounds that show health benefits on the liver. However, there is little investigation about identification and evaluation of new flavonoid-containing drugs for cholestatic liver disease, one of the most common liver illnesses. We aimed to a systematic search regarding efficacy of flavonoids for treatment of cholestatic liver disease, and then evaluate naringenin (NG) as representative flavonoid in an obstructive cholestasis model. We searched for information of experimental and clinical studies in four major databases without time and language limits. Intervention was defined as any flavonoid derivate compared with other flavonoid, placebo, or without comparator. In addition, we evaluated NG on a bile duct-ligated model in order to contribute evidence of its actions. Eleven experimental reports that support the efficacy of flavonoids in cholestatic liver disease were identified. However, there was no homogeneity in efficacy endpoints evaluated and methodology. On the other hand, NG showed beneficial effects by improving specific metabolic (cholesterol and lipoproteins) and liver damage (bilirubin and alkaline phosphatase) biomarkers. The review lacks homogeneous evidence about efficacy of flavonoids in experimental settings, and is susceptible to risk for bias. NG only showed improvements in specific disease biomarkers. More investigation is still needed to determine its potential for drug development.http://www.mdpi.com/2218-273X/9/3/102flavonoidssystematic reviewcholestasis
spellingShingle Juan Carlos Sánchez-Salgado
Samuel Estrada-Soto
Sara García-Jiménez
Sergio Montes
Jaime Gómez-Zamudio
Rafael Villalobos-Molina
Analysis of Flavonoids Bioactivity for Cholestatic Liver Disease: Systematic Literature Search and Experimental Approaches
Biomolecules
flavonoids
systematic review
cholestasis
title Analysis of Flavonoids Bioactivity for Cholestatic Liver Disease: Systematic Literature Search and Experimental Approaches
title_full Analysis of Flavonoids Bioactivity for Cholestatic Liver Disease: Systematic Literature Search and Experimental Approaches
title_fullStr Analysis of Flavonoids Bioactivity for Cholestatic Liver Disease: Systematic Literature Search and Experimental Approaches
title_full_unstemmed Analysis of Flavonoids Bioactivity for Cholestatic Liver Disease: Systematic Literature Search and Experimental Approaches
title_short Analysis of Flavonoids Bioactivity for Cholestatic Liver Disease: Systematic Literature Search and Experimental Approaches
title_sort analysis of flavonoids bioactivity for cholestatic liver disease systematic literature search and experimental approaches
topic flavonoids
systematic review
cholestasis
url http://www.mdpi.com/2218-273X/9/3/102
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