Polyunsaturated fatty acid in treatment resistant depression: A pilot study
Introduction The deficiency of polyunsaturated fatty acids (PUFAs) and an alteration between the ratio of omega-6 and omega-3 PUFAs may contribute to the pathogenesis of depressive disorders. Objectives To investigate the levels of omega-3 and omega-6 in red cell membranes (mPUFAs) and plasma (p...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-04-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933821008683/type/journal_article |
| _version_ | 1827753806987788288 |
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| author | T. Jannini L. Longo Y. Barone C. Niolu S. Bernardini A. Siracusano P. Bertucci G. Di Lorenzo |
| author_facet | T. Jannini L. Longo Y. Barone C. Niolu S. Bernardini A. Siracusano P. Bertucci G. Di Lorenzo |
| author_sort | T. Jannini |
| collection | DOAJ |
| description |
Introduction
The deficiency of polyunsaturated fatty acids (PUFAs) and an alteration between the ratio of omega-6 and omega-3 PUFAs may contribute to the pathogenesis of depressive disorders.
Objectives
To investigate the levels of omega-3 and omega-6 in red cell membranes (mPUFAs) and plasma (pPUFAs) of patients with treatment-resistant (TRD) and non-treatment resistant depression (non-TRD).
Methods
TRD and non-TRD consisted of 75 patients enrolled at the Psychiatric and Clinic Psychology Unit of the University of Rome Tor Vergata, Rome, Italy, and met the DSM-IV criteria for major depressive disorder (MDD). A group of healthy controls (HC) matched for agender and age was enrolled. All blood samples were performed in conditions of an empty stomach between 07:00 am and 09:00 am. For each subject were obtained 5 ml of whole blood with the use of tubes for plasma with EDTA as an anticoagulant. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) for omega-3 and arachidonic acid (AA) for omega-6 were measured.
Results
Levels of pPUFAs did not differ between the three groups. The mPUFAs were altered in the MDD. TRD and non-TRD had lower EPA and AA values respect to the HC. DHA in red cell membranes was lower in TRD than non-TRD and HC.
Conclusions
Changes in levels of PUFAs in red cell membranes, but not in plasma, may be an important factor to evaluate the resistance to the pharmacological treatment.
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| first_indexed | 2024-03-11T07:40:22Z |
| format | Article |
| id | doaj.art-b8f08b9221e1434c8ec64b464b198fe1 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:40:22Z |
| publishDate | 2021-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-b8f08b9221e1434c8ec64b464b198fe12023-11-17T05:08:38ZengCambridge University PressEuropean Psychiatry0924-93381778-35852021-04-0164S323S32410.1192/j.eurpsy.2021.868Polyunsaturated fatty acid in treatment resistant depression: A pilot studyT. Jannini0L. Longo1Y. Barone2C. Niolu3S. Bernardini4A. Siracusano5P. Bertucci6G. Di Lorenzo7Department Of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyDepartment Of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyDepartment Of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyDepartment Of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyDepartment Of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyDepartment Of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyDepartment Of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyDepartment Of Systems Medicine, University of Rome Tor Vergata, Rome, Italy Introduction The deficiency of polyunsaturated fatty acids (PUFAs) and an alteration between the ratio of omega-6 and omega-3 PUFAs may contribute to the pathogenesis of depressive disorders. Objectives To investigate the levels of omega-3 and omega-6 in red cell membranes (mPUFAs) and plasma (pPUFAs) of patients with treatment-resistant (TRD) and non-treatment resistant depression (non-TRD). Methods TRD and non-TRD consisted of 75 patients enrolled at the Psychiatric and Clinic Psychology Unit of the University of Rome Tor Vergata, Rome, Italy, and met the DSM-IV criteria for major depressive disorder (MDD). A group of healthy controls (HC) matched for agender and age was enrolled. All blood samples were performed in conditions of an empty stomach between 07:00 am and 09:00 am. For each subject were obtained 5 ml of whole blood with the use of tubes for plasma with EDTA as an anticoagulant. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) for omega-3 and arachidonic acid (AA) for omega-6 were measured. Results Levels of pPUFAs did not differ between the three groups. The mPUFAs were altered in the MDD. TRD and non-TRD had lower EPA and AA values respect to the HC. DHA in red cell membranes was lower in TRD than non-TRD and HC. Conclusions Changes in levels of PUFAs in red cell membranes, but not in plasma, may be an important factor to evaluate the resistance to the pharmacological treatment. https://www.cambridge.org/core/product/identifier/S0924933821008683/type/journal_articlefatty acidsTreatment Resistant Depressionomega3omega6 |
| spellingShingle | T. Jannini L. Longo Y. Barone C. Niolu S. Bernardini A. Siracusano P. Bertucci G. Di Lorenzo Polyunsaturated fatty acid in treatment resistant depression: A pilot study European Psychiatry fatty acids Treatment Resistant Depression omega3 omega6 |
| title | Polyunsaturated fatty acid in treatment resistant depression: A pilot study |
| title_full | Polyunsaturated fatty acid in treatment resistant depression: A pilot study |
| title_fullStr | Polyunsaturated fatty acid in treatment resistant depression: A pilot study |
| title_full_unstemmed | Polyunsaturated fatty acid in treatment resistant depression: A pilot study |
| title_short | Polyunsaturated fatty acid in treatment resistant depression: A pilot study |
| title_sort | polyunsaturated fatty acid in treatment resistant depression a pilot study |
| topic | fatty acids Treatment Resistant Depression omega3 omega6 |
| url | https://www.cambridge.org/core/product/identifier/S0924933821008683/type/journal_article |
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