Overexpression of Alpha-1 Antitrypsin Increases the Proliferation of Mesenchymal Stem Cells by Upregulation of Cyclin D1

Overexpression of Alpha-1 Antitrypsin Increases the Proliferation of Mesenchymal Stem Cells by Upregulation of Cyclin D1

Alpha-1 antitrypsin-overexpressing mesenchymal stromal/stem cells (AAT-MSCs) showed improved innate properties with a faster proliferation rate when studied for their protective effects in mouse models of diseases. Here, we investigated the potential mechanism(s) by which AAT gene insertion increase...

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Bibliographic Details
Main Authors: Bryan Wolf, Prasanth Muralidharan, Michael Y. Lee, Wei Hua, Erica Green, Hongjun Wang, Charlie Strange
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
mesenchymal stromal/stem cells
alpha-1 antitrypsin
cell proliferation
Cyclin D1
Online Access:https://www.mdpi.com/1422-0067/25/4/2015

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