Impact of a new vaccine clinic on hepatitis B vaccine completion and immunological response rates in an HIV-positive cohort
Summary: Introduction: Hepatitis B virus vaccination (HBVV) in the HIV-infected population has poor reported completion rates and immunological response rates. At our HIV clinic, we established a vaccine clinic to improve HBVV outcomes using interventions such as SMS text reminders and double-dose...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-06-01
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| Series: | Journal of Infection and Public Health |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034112001748 |
| _version_ | 1818947803246755840 |
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| author | Clare Rock Eoghan de Barra Corinna Sadlier Sinead Kelly Catherine Dowling Cora McNally Colm Bergin |
| author_facet | Clare Rock Eoghan de Barra Corinna Sadlier Sinead Kelly Catherine Dowling Cora McNally Colm Bergin |
| author_sort | Clare Rock |
| collection | DOAJ |
| description | Summary: Introduction: Hepatitis B virus vaccination (HBVV) in the HIV-infected population has poor reported completion rates and immunological response rates. At our HIV clinic, we established a vaccine clinic to improve HBVV outcomes using interventions such as SMS text reminders and double-dose (DD) HBVV for standard-dose non-responders (SD NRs). Methods: A five-year (2003–2008) retrospective review of the completion rates and immunological response rates for HBVV after the establishment of the dedicated vaccine clinic was conducted. Statistical significance was assumed at p < 0.05, and the analysis was performed using SPSS (v16). Results: A total of 354 HIV-infected patients were included. Seventy-five percent (268/354) of patients completed the SD HBVV, an 84% (226/268) returned for the hepatitis B surface antibody evaluation. Only 47.3% (107/226) responded to standard-dose hepatitis B vaccination. Responders had higher absolute numbers (p = 0.017) and percentages of CD4 cells (p < 0.001) and were more likely to be receiving HAART (p = 0.001). There was a 70% (48/69) response rate to DD HBVV among SD NRs. On-treatment analysis showed an 88% (155/176) overall immunological response to SD HBVV and DD HBVV, if required. Conclusion: High HBVV completion and response rates in this HIV cohort were enabled through the use of multiple interventions, including the use of SMS text message reminders and routine referral for DD vaccination. Keywords: Hepatitis B, HIV, Hepatitis B vaccination, Hepatitis B vaccination outcomes |
| first_indexed | 2024-12-20T08:36:42Z |
| format | Article |
| id | doaj.art-b8f199a93d5b4defb68d29f0ce9de644 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-12-20T08:36:42Z |
| publishDate | 2013-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-b8f199a93d5b4defb68d29f0ce9de6442022-12-21T19:46:33ZengElsevierJournal of Infection and Public Health1876-03412013-06-0163173178Impact of a new vaccine clinic on hepatitis B vaccine completion and immunological response rates in an HIV-positive cohortClare Rock0Eoghan de Barra1Corinna Sadlier2Sinead Kelly3Catherine Dowling4Cora McNally5Colm Bergin6Department of Infectious Diseases, University of Maryland, Baltimore, MD 21201, USA; Corresponding author. Tel.: +1 4438313602.Department of Genitourinary Medicine and Infectious Diseases, St. James Hospital, Dublin 8, IrelandDepartment of Genitourinary Medicine and Infectious Diseases, St. James Hospital, Dublin 8, IrelandDepartment of Genitourinary Medicine and Infectious Diseases, St. James Hospital, Dublin 8, IrelandDepartment of Genitourinary Medicine and Infectious Diseases, St. James Hospital, Dublin 8, IrelandDepartment of Genitourinary Medicine and Infectious Diseases, St. James Hospital, Dublin 8, IrelandDepartment of Genitourinary Medicine and Infectious Diseases, St. James Hospital, Dublin 8, IrelandSummary: Introduction: Hepatitis B virus vaccination (HBVV) in the HIV-infected population has poor reported completion rates and immunological response rates. At our HIV clinic, we established a vaccine clinic to improve HBVV outcomes using interventions such as SMS text reminders and double-dose (DD) HBVV for standard-dose non-responders (SD NRs). Methods: A five-year (2003–2008) retrospective review of the completion rates and immunological response rates for HBVV after the establishment of the dedicated vaccine clinic was conducted. Statistical significance was assumed at p < 0.05, and the analysis was performed using SPSS (v16). Results: A total of 354 HIV-infected patients were included. Seventy-five percent (268/354) of patients completed the SD HBVV, an 84% (226/268) returned for the hepatitis B surface antibody evaluation. Only 47.3% (107/226) responded to standard-dose hepatitis B vaccination. Responders had higher absolute numbers (p = 0.017) and percentages of CD4 cells (p < 0.001) and were more likely to be receiving HAART (p = 0.001). There was a 70% (48/69) response rate to DD HBVV among SD NRs. On-treatment analysis showed an 88% (155/176) overall immunological response to SD HBVV and DD HBVV, if required. Conclusion: High HBVV completion and response rates in this HIV cohort were enabled through the use of multiple interventions, including the use of SMS text message reminders and routine referral for DD vaccination. Keywords: Hepatitis B, HIV, Hepatitis B vaccination, Hepatitis B vaccination outcomeshttp://www.sciencedirect.com/science/article/pii/S1876034112001748 |
| spellingShingle | Clare Rock Eoghan de Barra Corinna Sadlier Sinead Kelly Catherine Dowling Cora McNally Colm Bergin Impact of a new vaccine clinic on hepatitis B vaccine completion and immunological response rates in an HIV-positive cohort Journal of Infection and Public Health |
| title | Impact of a new vaccine clinic on hepatitis B vaccine completion and immunological response rates in an HIV-positive cohort |
| title_full | Impact of a new vaccine clinic on hepatitis B vaccine completion and immunological response rates in an HIV-positive cohort |
| title_fullStr | Impact of a new vaccine clinic on hepatitis B vaccine completion and immunological response rates in an HIV-positive cohort |
| title_full_unstemmed | Impact of a new vaccine clinic on hepatitis B vaccine completion and immunological response rates in an HIV-positive cohort |
| title_short | Impact of a new vaccine clinic on hepatitis B vaccine completion and immunological response rates in an HIV-positive cohort |
| title_sort | impact of a new vaccine clinic on hepatitis b vaccine completion and immunological response rates in an hiv positive cohort |
| url | http://www.sciencedirect.com/science/article/pii/S1876034112001748 |
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