1,3-Dibromo-5,5-dimethylhydantoin as promoter for glycosylations using thioglycosides

1,3-Dibromo-5,5-dimethylhydantoin as promoter for glycosylations using thioglycosides

1,3-Dibromo-5,5-dimethylhydantoin (DBDMH), an inexpensive, non-toxic and stable reagent, is a competent activator of thioglycosides for glycosidic bond formation. Excellent yields were obtained when triflic acid (TfOH) or trimethylsilyl trifluoromethanesulfonate (TMSOTf) were employed as co-promoter...

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Bibliographic Details
Main Authors: Fei-Fei Xu, Claney L. Pereira, Peter H. Seeberger
Format: Article
Language:English
Published: Beilstein-Institut 2017-09-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
automated glycan assembly
1,3-dibromo-5,5-dimethylhydantoin
glycosylation
promoter
thioglycosides
Online Access:https://doi.org/10.3762/bjoc.13.195

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