Influence of presence/absence of thyroid gland on the cutoff value for thyroglobulin in lymph-node aspiration to detect metastatic papillary thyroid carcinoma
Abstract Background Thyroglobulin measurement with fine-needle aspiration (Tg-FNA) is a sensitive method for detecting metastatic papillary thyroid carcinoma (PTC). However, the diagnostic threshold is not well established and the influence of the thyroid gland on the cutoff value is also controvers...
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BMC
2017-04-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-017-3296-3 |
| _version_ | 1819212664157503488 |
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| author | Huan Zhao Yong Wang Min-jie Wang Zhi-hui Zhang Hai-rui Wang Bing Zhang Hui-qin Guo |
| author_facet | Huan Zhao Yong Wang Min-jie Wang Zhi-hui Zhang Hai-rui Wang Bing Zhang Hui-qin Guo |
| author_sort | Huan Zhao |
| collection | DOAJ |
| description | Abstract Background Thyroglobulin measurement with fine-needle aspiration (Tg-FNA) is a sensitive method for detecting metastatic papillary thyroid carcinoma (PTC). However, the diagnostic threshold is not well established and the influence of the thyroid gland on the cutoff value is also controversial. In this study, patients were classified into two groups according to the presence or absence of thyroid tissue, to determine an appropriate cutoff value for clinical practice. Methods Patients with a history of thyroid nodules or surgery for PTC and with enlarged cervical lymph nodes on an FNA examination were enrolled for Tg-FNA detection. Results One hundred ninety-six lymph nodes (189 patients) were included: 100 from preoperative patients, 49 from patients treated with partial thyroid ablation, and 47 from patients with total thyroid ablation. In 149 lymph nodes from patient with thyroids, the cutoff value for Tg-FNA was 55.99 ng/mL (sensitivity, 95.1%; specificity, 100%), whereas in 47 lymph nodes from patients without a thyroid, it was 9.71 ng/mL (sensitivity, 96.7%; specificity, 100%). Thus, the cutoff value for Tg-FNA was higher in patients with thyroids than in patients without thyroids. Conclusions The cutoff value for Tg-FNA is influenced by residual thyroid tissue, and a higher cutoff value is recommended for patients with thyroids than for patients without thyroids. |
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| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-23T06:46:33Z |
| publishDate | 2017-04-01 |
| publisher | BMC |
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| series | BMC Cancer |
| spelling | doaj.art-b8f1b6a21ba144d4aa843fd3bac1e65e2022-12-21T17:56:33ZengBMCBMC Cancer1471-24072017-04-011711710.1186/s12885-017-3296-3Influence of presence/absence of thyroid gland on the cutoff value for thyroglobulin in lymph-node aspiration to detect metastatic papillary thyroid carcinomaHuan Zhao0Yong Wang1Min-jie Wang2Zhi-hui Zhang3Hai-rui Wang4Bing Zhang5Hui-qin Guo6Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Clinical Library, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cancer Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Head and Neck Surgery, Peking University Cancer HospitalDepartment of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Background Thyroglobulin measurement with fine-needle aspiration (Tg-FNA) is a sensitive method for detecting metastatic papillary thyroid carcinoma (PTC). However, the diagnostic threshold is not well established and the influence of the thyroid gland on the cutoff value is also controversial. In this study, patients were classified into two groups according to the presence or absence of thyroid tissue, to determine an appropriate cutoff value for clinical practice. Methods Patients with a history of thyroid nodules or surgery for PTC and with enlarged cervical lymph nodes on an FNA examination were enrolled for Tg-FNA detection. Results One hundred ninety-six lymph nodes (189 patients) were included: 100 from preoperative patients, 49 from patients treated with partial thyroid ablation, and 47 from patients with total thyroid ablation. In 149 lymph nodes from patient with thyroids, the cutoff value for Tg-FNA was 55.99 ng/mL (sensitivity, 95.1%; specificity, 100%), whereas in 47 lymph nodes from patients without a thyroid, it was 9.71 ng/mL (sensitivity, 96.7%; specificity, 100%). Thus, the cutoff value for Tg-FNA was higher in patients with thyroids than in patients without thyroids. Conclusions The cutoff value for Tg-FNA is influenced by residual thyroid tissue, and a higher cutoff value is recommended for patients with thyroids than for patients without thyroids.http://link.springer.com/article/10.1186/s12885-017-3296-3ThyroglobulinFine-needle aspirateCutoffPapillary thyroid carcinomaLymph node |
| spellingShingle | Huan Zhao Yong Wang Min-jie Wang Zhi-hui Zhang Hai-rui Wang Bing Zhang Hui-qin Guo Influence of presence/absence of thyroid gland on the cutoff value for thyroglobulin in lymph-node aspiration to detect metastatic papillary thyroid carcinoma BMC Cancer Thyroglobulin Fine-needle aspirate Cutoff Papillary thyroid carcinoma Lymph node |
| title | Influence of presence/absence of thyroid gland on the cutoff value for thyroglobulin in lymph-node aspiration to detect metastatic papillary thyroid carcinoma |
| title_full | Influence of presence/absence of thyroid gland on the cutoff value for thyroglobulin in lymph-node aspiration to detect metastatic papillary thyroid carcinoma |
| title_fullStr | Influence of presence/absence of thyroid gland on the cutoff value for thyroglobulin in lymph-node aspiration to detect metastatic papillary thyroid carcinoma |
| title_full_unstemmed | Influence of presence/absence of thyroid gland on the cutoff value for thyroglobulin in lymph-node aspiration to detect metastatic papillary thyroid carcinoma |
| title_short | Influence of presence/absence of thyroid gland on the cutoff value for thyroglobulin in lymph-node aspiration to detect metastatic papillary thyroid carcinoma |
| title_sort | influence of presence absence of thyroid gland on the cutoff value for thyroglobulin in lymph node aspiration to detect metastatic papillary thyroid carcinoma |
| topic | Thyroglobulin Fine-needle aspirate Cutoff Papillary thyroid carcinoma Lymph node |
| url | http://link.springer.com/article/10.1186/s12885-017-3296-3 |
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