Identification of linderalactone as a natural inhibitor of SHP2 to ameliorate CCl4-induced liver fibrosis

Identification of linderalactone as a natural inhibitor of SHP2 to ameliorate CCl4-induced liver fibrosis

Liver fibrosis is characterised by the activation of hepatic stellate cells (HSCs) and matrix deposition. Accumulating evidence has revealed that the oncogenic protein tyrosine phosphatase Src homology 2 domain-containing phosphatase 2 (SHP2) acts as a therapeutic target of fibrosis. Although severa...

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Bibliographic Details
Main Authors: Yi Zhang, Binhao Cai, Yingying Li, Ying Xu, Yuhan Wang, Lulu Zheng, Xiaochun Zheng, Lina Yin, Gaozhi Chen, Yunxiang Wang, Guang Liang, Lingfeng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pharmacology
Subjects:
Src homology 2 domain-containing phosphatase 2
liver fibrosis
high-throughput screening
linderalactone
natural products
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1098463/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1098463/full

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