Bone resorption: an actor of dental and periodontal development?
Dental and periodontal tissue development is a complex process involving various cell-types. A finely orchestrated network of communications between these cells is implicated. During early development, communications between cells from the oral epithelium and the underlying mesenchyme govern the den...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00319/full |
| _version_ | 1818292804039737344 |
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| author | Andrea eGama Andrea eGama Benjamin eNavet Benjamin eNavet Jorge William Vargas Jorge William Vargas Beatriz eCastaneda Beatriz eCastaneda Frederic eLezot Frederic eLezot |
| author_facet | Andrea eGama Andrea eGama Benjamin eNavet Benjamin eNavet Jorge William Vargas Jorge William Vargas Beatriz eCastaneda Beatriz eCastaneda Frederic eLezot Frederic eLezot |
| author_sort | Andrea eGama |
| collection | DOAJ |
| description | Dental and periodontal tissue development is a complex process involving various cell-types. A finely orchestrated network of communications between these cells is implicated. During early development, communications between cells from the oral epithelium and the underlying mesenchyme govern the dental morphogenesis with successive bud, cap and bell stages. Later, interactions between epithelial and mesenchymal cells occur during dental root elongation. Root elongation and tooth eruption require resorption of surrounding alveolar bone to occur. For years, it was postulated that signaling molecules secreted by dental and periodontal cells control bone resorbing osteoclast precursor recruitment and differentiation. Reverse signaling originating from bone cells (osteoclasts and osteoblasts) toward dental cells was not suspected. Dental defects reported in osteopetrosis were associated with mechanical stress secondary to defective bone resorption. In the last decade, consequences of bone resorption over-activation on dental and periodontal tissue formation have been analyzed with transgenic animals (RankTg and Opg-/- mice). Results suggest the existence of signals originating from osteoclasts toward dental and periodontal cells. Meanwhile, experiments consisting in transitory inhibition of bone resorption during root elongation, achieved with bone resorption inhibitors having different mechanisms of action (bisphosphonates and RANKL blocking antibodies), have evidenced dental and periodontal defects that support the presence of signals originating bone cells toward dental cells. The aim of the present manuscript is to present the data we have collected in the last years that support the hypothesis of a role of bone resorption in dental and periodontal development. |
| first_indexed | 2024-12-13T03:05:46Z |
| format | Article |
| id | doaj.art-b8f32076d163427288711975bfb2b06f |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-13T03:05:46Z |
| publishDate | 2015-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-b8f32076d163427288711975bfb2b06f2022-12-22T00:01:43ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2015-11-01610.3389/fphys.2015.00319163875Bone resorption: an actor of dental and periodontal development?Andrea eGama0Andrea eGama1Benjamin eNavet2Benjamin eNavet3Jorge William Vargas4Jorge William Vargas5Beatriz eCastaneda6Beatriz eCastaneda7Frederic eLezot8Frederic eLezot9INSERM, UMR-1138, Equipe 5Odontologic Center of District Federal Military PoliceINSERM UMR957Université de Nantes, Faculté de Médecine, Laboratoire de physiopathologie de la résorption osseuse et thérapie des tumeurs osseuses primitivesINSERM UMR957Department of Basic Studies, Faculty of Odontology, University of AntioquiaINSERM, UMR-1138, Equipe 5Department of Basic Studies, Faculty of Odontology, University of AntioquiaINSERM UMR957Université de Nantes, Faculté de Médecine, Laboratoire de physiopathologie de la résorption osseuse et thérapie des tumeurs osseuses primitivesDental and periodontal tissue development is a complex process involving various cell-types. A finely orchestrated network of communications between these cells is implicated. During early development, communications between cells from the oral epithelium and the underlying mesenchyme govern the dental morphogenesis with successive bud, cap and bell stages. Later, interactions between epithelial and mesenchymal cells occur during dental root elongation. Root elongation and tooth eruption require resorption of surrounding alveolar bone to occur. For years, it was postulated that signaling molecules secreted by dental and periodontal cells control bone resorbing osteoclast precursor recruitment and differentiation. Reverse signaling originating from bone cells (osteoclasts and osteoblasts) toward dental cells was not suspected. Dental defects reported in osteopetrosis were associated with mechanical stress secondary to defective bone resorption. In the last decade, consequences of bone resorption over-activation on dental and periodontal tissue formation have been analyzed with transgenic animals (RankTg and Opg-/- mice). Results suggest the existence of signals originating from osteoclasts toward dental and periodontal cells. Meanwhile, experiments consisting in transitory inhibition of bone resorption during root elongation, achieved with bone resorption inhibitors having different mechanisms of action (bisphosphonates and RANKL blocking antibodies), have evidenced dental and periodontal defects that support the presence of signals originating bone cells toward dental cells. The aim of the present manuscript is to present the data we have collected in the last years that support the hypothesis of a role of bone resorption in dental and periodontal development.http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00319/fullBone ResorptionToothMSX2RANKLZoledronic Acid |
| spellingShingle | Andrea eGama Andrea eGama Benjamin eNavet Benjamin eNavet Jorge William Vargas Jorge William Vargas Beatriz eCastaneda Beatriz eCastaneda Frederic eLezot Frederic eLezot Bone resorption: an actor of dental and periodontal development? Frontiers in Physiology Bone Resorption Tooth MSX2 RANKL Zoledronic Acid |
| title | Bone resorption: an actor of dental and periodontal development? |
| title_full | Bone resorption: an actor of dental and periodontal development? |
| title_fullStr | Bone resorption: an actor of dental and periodontal development? |
| title_full_unstemmed | Bone resorption: an actor of dental and periodontal development? |
| title_short | Bone resorption: an actor of dental and periodontal development? |
| title_sort | bone resorption an actor of dental and periodontal development |
| topic | Bone Resorption Tooth MSX2 RANKL Zoledronic Acid |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00319/full |
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