Influence of Renal Impairment on Serum Parathyroid Hormone and Vitamin D Status and their Association with Serum Creatinine in Patients Undergoing Haemodialysis: A Case-control Study
Introduction: A transition in the lifestyle of Saudi population over the past few decades has increased the burden of various metabolic disorders including, diabetes mellitus type 2, Chronic Kidney Disease (CKD), cardiovascular diseases, and vitamin D deficiency. Deficiency of vitamin D has been...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2021-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/15271/48899_CE[Ra1]_F(SL)_PF1(SC_SL)_PFA(SC_KM)_PN(KM).pdf |
| Summary: | Introduction: A transition in the lifestyle of Saudi population over
the past few decades has increased the burden of various metabolic
disorders including, diabetes mellitus type 2, Chronic Kidney Disease
(CKD), cardiovascular diseases, and vitamin D deficiency. Deficiency
of vitamin D has been linked to the progression of kidney disease
and many cardiovascular complications.
Aim: The study focuses on the vitamin D status and associated
changes in serum Parathyroid Hormone (PTH) in End Stage
Renal Disease (ESRD) patients undergoing haemodialysis in
the Northern Border Region (Arar city) of Saudi Arabia. The
present study also investigated the relationship between serum
creatinine, PTH and vitamin D levels in these patients.
Materials and Methods: This case-control study was carried out
for a period of five months (September 2019 to January 2020).
It included 60 patients, suffering from ESRD on haemodialysis
(cases) attending the Nephrology Centre of Prince Mohammed
bin Saud Al Kabeer renal dialysis unit in Arar Central Hospital,
Arar, Saudi Arabia. A control population (n=60) with normal
kidney function, who visited the hospital for other reasons,
was also identified. Their blood samples were collected for
estimation of renal function parameters {Blood Urea Nitrogen
(BUN) and creatinine}, serum calcium, phosphate, vitamin D
and PTH. Statistical analysis was performed using the Statistical
Package for the Social Sciences version 22.0.
Results: The study included 60 patients (50% males and
50% females) undergoing haemodialysis and 60 healthy
controls (50% males and 50% females) with a mean age of
46.83±14.19 (range 18-73 years) and 39.25±5.11 (range 30-
54 years) years, respectively. The mean BMI of the patients
was 27.3±3.4, kg/m2 and that of controls was 23.7±2.2 kg/m2.
A significant elevation (p-value<0.001) of serum PTH
showing hyperparathyroidism accompanied by significant
(p-value<0.001) hypovitaminosis D and hypocalcaemia was
observed in the patients as compared to controls. The results
also demonstrated significantly elevated (p-value<0.001)
levels of BUN and serum creatinine in ESRD patients. Results
of correlation analysis exhibited a significant (p-value<0.05)
positive correlation between serum creatinine and PTH
whereas, there was a significant (p-value<0.05) negative
correlation between serum creatinine and vitamin D; and
serum PTH and vitamin D among the patients.
Conclusion: This study highlights the importance of monitoring
changes in PTH levels in patients with impaired renal function
for the early detection and treatment of CKD. The study also
showed a significant (p<0.05) positive association between
serum creatinine and PTH followed by a significant (p<0.05)
negative correlation between serum creatinine and vitamin D;
and serum PTH and vitamin D. |
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| ISSN: | 2249-782X 0973-709X |