Influence of Renal Impairment on Serum Parathyroid Hormone and Vitamin D Status and their Association with Serum Creatinine in Patients Undergoing Haemodialysis: A Case-control Study
Introduction: A transition in the lifestyle of Saudi population over the past few decades has increased the burden of various metabolic disorders including, diabetes mellitus type 2, Chronic Kidney Disease (CKD), cardiovascular diseases, and vitamin D deficiency. Deficiency of vitamin D has been...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2021-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/15271/48899_CE[Ra1]_F(SL)_PF1(SC_SL)_PFA(SC_KM)_PN(KM).pdf |
| _version_ | 1818722416425172992 |
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| author | Nida Suhail Baraah Tomah Abualsel Shiza Batool |
| author_facet | Nida Suhail Baraah Tomah Abualsel Shiza Batool |
| author_sort | Nida Suhail |
| collection | DOAJ |
| description | Introduction: A transition in the lifestyle of Saudi population over
the past few decades has increased the burden of various metabolic
disorders including, diabetes mellitus type 2, Chronic Kidney Disease
(CKD), cardiovascular diseases, and vitamin D deficiency. Deficiency
of vitamin D has been linked to the progression of kidney disease
and many cardiovascular complications.
Aim: The study focuses on the vitamin D status and associated
changes in serum Parathyroid Hormone (PTH) in End Stage
Renal Disease (ESRD) patients undergoing haemodialysis in
the Northern Border Region (Arar city) of Saudi Arabia. The
present study also investigated the relationship between serum
creatinine, PTH and vitamin D levels in these patients.
Materials and Methods: This case-control study was carried out
for a period of five months (September 2019 to January 2020).
It included 60 patients, suffering from ESRD on haemodialysis
(cases) attending the Nephrology Centre of Prince Mohammed
bin Saud Al Kabeer renal dialysis unit in Arar Central Hospital,
Arar, Saudi Arabia. A control population (n=60) with normal
kidney function, who visited the hospital for other reasons,
was also identified. Their blood samples were collected for
estimation of renal function parameters {Blood Urea Nitrogen
(BUN) and creatinine}, serum calcium, phosphate, vitamin D
and PTH. Statistical analysis was performed using the Statistical
Package for the Social Sciences version 22.0.
Results: The study included 60 patients (50% males and
50% females) undergoing haemodialysis and 60 healthy
controls (50% males and 50% females) with a mean age of
46.83±14.19 (range 18-73 years) and 39.25±5.11 (range 30-
54 years) years, respectively. The mean BMI of the patients
was 27.3±3.4, kg/m2 and that of controls was 23.7±2.2 kg/m2.
A significant elevation (p-value<0.001) of serum PTH
showing hyperparathyroidism accompanied by significant
(p-value<0.001) hypovitaminosis D and hypocalcaemia was
observed in the patients as compared to controls. The results
also demonstrated significantly elevated (p-value<0.001)
levels of BUN and serum creatinine in ESRD patients. Results
of correlation analysis exhibited a significant (p-value<0.05)
positive correlation between serum creatinine and PTH
whereas, there was a significant (p-value<0.05) negative
correlation between serum creatinine and vitamin D; and
serum PTH and vitamin D among the patients.
Conclusion: This study highlights the importance of monitoring
changes in PTH levels in patients with impaired renal function
for the early detection and treatment of CKD. The study also
showed a significant (p<0.05) positive association between
serum creatinine and PTH followed by a significant (p<0.05)
negative correlation between serum creatinine and vitamin D;
and serum PTH and vitamin D. |
| first_indexed | 2024-12-17T20:54:17Z |
| format | Article |
| id | doaj.art-b8f42d6ce63f4bdbaa7ffac9138cedae |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-17T20:54:17Z |
| publishDate | 2021-08-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-b8f42d6ce63f4bdbaa7ffac9138cedae2022-12-21T21:32:55ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-08-01158BC08BC1110.7860/JCDR/2021/48899.15271Influence of Renal Impairment on Serum Parathyroid Hormone and Vitamin D Status and their Association with Serum Creatinine in Patients Undergoing Haemodialysis: A Case-control StudyNida Suhail0Baraah Tomah Abualsel1Shiza Batool2Assistant Professor, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Northern Border University, Arar, Northern Borders, Saudi Arabia.Lecturer, Department of Pathology, Faculty of Medicine, Northern Border University, Arar, Northern Borders, Saudi Arabia.Lecturer, Department of Biochemistry, Faculty of Medicine, Northern Border University, Arar, Northern Borders, Saudi Arabia.Introduction: A transition in the lifestyle of Saudi population over the past few decades has increased the burden of various metabolic disorders including, diabetes mellitus type 2, Chronic Kidney Disease (CKD), cardiovascular diseases, and vitamin D deficiency. Deficiency of vitamin D has been linked to the progression of kidney disease and many cardiovascular complications. Aim: The study focuses on the vitamin D status and associated changes in serum Parathyroid Hormone (PTH) in End Stage Renal Disease (ESRD) patients undergoing haemodialysis in the Northern Border Region (Arar city) of Saudi Arabia. The present study also investigated the relationship between serum creatinine, PTH and vitamin D levels in these patients. Materials and Methods: This case-control study was carried out for a period of five months (September 2019 to January 2020). It included 60 patients, suffering from ESRD on haemodialysis (cases) attending the Nephrology Centre of Prince Mohammed bin Saud Al Kabeer renal dialysis unit in Arar Central Hospital, Arar, Saudi Arabia. A control population (n=60) with normal kidney function, who visited the hospital for other reasons, was also identified. Their blood samples were collected for estimation of renal function parameters {Blood Urea Nitrogen (BUN) and creatinine}, serum calcium, phosphate, vitamin D and PTH. Statistical analysis was performed using the Statistical Package for the Social Sciences version 22.0. Results: The study included 60 patients (50% males and 50% females) undergoing haemodialysis and 60 healthy controls (50% males and 50% females) with a mean age of 46.83±14.19 (range 18-73 years) and 39.25±5.11 (range 30- 54 years) years, respectively. The mean BMI of the patients was 27.3±3.4, kg/m2 and that of controls was 23.7±2.2 kg/m2. A significant elevation (p-value<0.001) of serum PTH showing hyperparathyroidism accompanied by significant (p-value<0.001) hypovitaminosis D and hypocalcaemia was observed in the patients as compared to controls. The results also demonstrated significantly elevated (p-value<0.001) levels of BUN and serum creatinine in ESRD patients. Results of correlation analysis exhibited a significant (p-value<0.05) positive correlation between serum creatinine and PTH whereas, there was a significant (p-value<0.05) negative correlation between serum creatinine and vitamin D; and serum PTH and vitamin D among the patients. Conclusion: This study highlights the importance of monitoring changes in PTH levels in patients with impaired renal function for the early detection and treatment of CKD. The study also showed a significant (p<0.05) positive association between serum creatinine and PTH followed by a significant (p<0.05) negative correlation between serum creatinine and vitamin D; and serum PTH and vitamin D.https://jcdr.net/articles/PDF/15271/48899_CE[Ra1]_F(SL)_PF1(SC_SL)_PFA(SC_KM)_PN(KM).pdfblood urea nitrogenchronic kidney diseasehyperparathyroidismsaudi arabiaserum calcium |
| spellingShingle | Nida Suhail Baraah Tomah Abualsel Shiza Batool Influence of Renal Impairment on Serum Parathyroid Hormone and Vitamin D Status and their Association with Serum Creatinine in Patients Undergoing Haemodialysis: A Case-control Study Journal of Clinical and Diagnostic Research blood urea nitrogen chronic kidney disease hyperparathyroidism saudi arabia serum calcium |
| title | Influence of Renal Impairment on Serum Parathyroid Hormone and Vitamin D Status and their Association with Serum Creatinine in Patients Undergoing Haemodialysis: A Case-control Study |
| title_full | Influence of Renal Impairment on Serum Parathyroid Hormone and Vitamin D Status and their Association with Serum Creatinine in Patients Undergoing Haemodialysis: A Case-control Study |
| title_fullStr | Influence of Renal Impairment on Serum Parathyroid Hormone and Vitamin D Status and their Association with Serum Creatinine in Patients Undergoing Haemodialysis: A Case-control Study |
| title_full_unstemmed | Influence of Renal Impairment on Serum Parathyroid Hormone and Vitamin D Status and their Association with Serum Creatinine in Patients Undergoing Haemodialysis: A Case-control Study |
| title_short | Influence of Renal Impairment on Serum Parathyroid Hormone and Vitamin D Status and their Association with Serum Creatinine in Patients Undergoing Haemodialysis: A Case-control Study |
| title_sort | influence of renal impairment on serum parathyroid hormone and vitamin d status and their association with serum creatinine in patients undergoing haemodialysis a case control study |
| topic | blood urea nitrogen chronic kidney disease hyperparathyroidism saudi arabia serum calcium |
| url | https://jcdr.net/articles/PDF/15271/48899_CE[Ra1]_F(SL)_PF1(SC_SL)_PFA(SC_KM)_PN(KM).pdf |
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