Lip Mesotherapy With Dexpanthenol As A Novel Approach To Prevent Isotretinoin-Associated Cheilitis
Introduction: Isotretinoin (ISO)-associated cheilitis is the most common side effect and the most common reason for discontinuation of ongoing therapy. So, various lip balms are also routinely recommended for all patients. Objectives: We aimed to investigate the effectiveness of local intradermal...
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| Format: | Article |
| Language: | English |
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Mattioli1885
2023-01-01
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| Series: | Dermatology Practical & Conceptual |
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| Online Access: | https://dpcj.org/index.php/dpc/article/view/2371 |
| _version_ | 1811172140960972800 |
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| author | Çağrı Turan Ümran Öner |
| author_facet | Çağrı Turan Ümran Öner |
| author_sort | Çağrı Turan |
| collection | DOAJ |
| description |
Introduction: Isotretinoin (ISO)-associated cheilitis is the most common side effect and the most common reason for discontinuation of ongoing therapy. So, various lip balms are also routinely recommended for all patients.
Objectives: We aimed to investigate the effectiveness of local intradermal injections (mesotherapy) of dexpanthenol into the lips to prevent ISO-associated cheilitis.
Methods: This pilot study was conducted on patients over the age of 18 using ISO (about 0.5 mg/kg/day). All patients were prescribed only hamamelis virginiana distillate in ointment form as a lip balm. In the mesotherapy group (n=28), 0.1 ml of dexpanthenol was injected into each lip tubercle (4 points total) to the submucosal level. The patients in the control group (n=26) used only the ointment. “ISO cheilitis grading scale (ICGS)” was used in the evaluation of ISO-associated cheilitis. The patients were followed for 2 months.
Results: Although there was an increase in ICGS scores in the mesotherapy group compared to the baseline, no statistically significant change was observed after treatment (p=0.545). However, in the control group, there was a statistically significant increase in ICGS scores in the 1st and 2nd months compared to the baseline (p<0.001). Lip balms were needed significantly less frequently in the mesotherapy group compared to the control, both in the 1st and 2nd months (p=0.006, p=0.045; respectively).
Conclusions: Lip mesotherapy with dexpanthenol will be a useful option for preventing ISO-associated cheilitis because of its easy application, cost-effectiveness, low complication risk, and high patient satisfaction.
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| first_indexed | 2024-04-10T17:26:15Z |
| format | Article |
| id | doaj.art-b8f76aaf3b694095983a0c8c03af0909 |
| institution | Directory Open Access Journal |
| issn | 2160-9381 |
| language | English |
| last_indexed | 2024-04-10T17:26:15Z |
| publishDate | 2023-01-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Dermatology Practical & Conceptual |
| spelling | doaj.art-b8f76aaf3b694095983a0c8c03af09092023-02-04T11:17:25ZengMattioli1885Dermatology Practical & Conceptual2160-93812023-01-0113110.5826/dpc.1301a12Lip Mesotherapy With Dexpanthenol As A Novel Approach To Prevent Isotretinoin-Associated CheilitisÇağrı Turan0Ümran Öner1Department of Dermatology and Venereology, Medical Park Ankara Hospital, Ankara, TurkeyDepartment of Dermatology and Venereology, Kastamonu University School of Medicine, Kastamonu, Turkey Introduction: Isotretinoin (ISO)-associated cheilitis is the most common side effect and the most common reason for discontinuation of ongoing therapy. So, various lip balms are also routinely recommended for all patients. Objectives: We aimed to investigate the effectiveness of local intradermal injections (mesotherapy) of dexpanthenol into the lips to prevent ISO-associated cheilitis. Methods: This pilot study was conducted on patients over the age of 18 using ISO (about 0.5 mg/kg/day). All patients were prescribed only hamamelis virginiana distillate in ointment form as a lip balm. In the mesotherapy group (n=28), 0.1 ml of dexpanthenol was injected into each lip tubercle (4 points total) to the submucosal level. The patients in the control group (n=26) used only the ointment. “ISO cheilitis grading scale (ICGS)” was used in the evaluation of ISO-associated cheilitis. The patients were followed for 2 months. Results: Although there was an increase in ICGS scores in the mesotherapy group compared to the baseline, no statistically significant change was observed after treatment (p=0.545). However, in the control group, there was a statistically significant increase in ICGS scores in the 1st and 2nd months compared to the baseline (p<0.001). Lip balms were needed significantly less frequently in the mesotherapy group compared to the control, both in the 1st and 2nd months (p=0.006, p=0.045; respectively). Conclusions: Lip mesotherapy with dexpanthenol will be a useful option for preventing ISO-associated cheilitis because of its easy application, cost-effectiveness, low complication risk, and high patient satisfaction. https://dpcj.org/index.php/dpc/article/view/2371cheilitisdexpanthenolisotretinoinmesotherapymucocutaneous side effect |
| spellingShingle | Çağrı Turan Ümran Öner Lip Mesotherapy With Dexpanthenol As A Novel Approach To Prevent Isotretinoin-Associated Cheilitis Dermatology Practical & Conceptual cheilitis dexpanthenol isotretinoin mesotherapy mucocutaneous side effect |
| title | Lip Mesotherapy With Dexpanthenol As A Novel Approach To Prevent Isotretinoin-Associated Cheilitis |
| title_full | Lip Mesotherapy With Dexpanthenol As A Novel Approach To Prevent Isotretinoin-Associated Cheilitis |
| title_fullStr | Lip Mesotherapy With Dexpanthenol As A Novel Approach To Prevent Isotretinoin-Associated Cheilitis |
| title_full_unstemmed | Lip Mesotherapy With Dexpanthenol As A Novel Approach To Prevent Isotretinoin-Associated Cheilitis |
| title_short | Lip Mesotherapy With Dexpanthenol As A Novel Approach To Prevent Isotretinoin-Associated Cheilitis |
| title_sort | lip mesotherapy with dexpanthenol as a novel approach to prevent isotretinoin associated cheilitis |
| topic | cheilitis dexpanthenol isotretinoin mesotherapy mucocutaneous side effect |
| url | https://dpcj.org/index.php/dpc/article/view/2371 |
| work_keys_str_mv | AT cagrıturan lipmesotherapywithdexpanthenolasanovelapproachtopreventisotretinoinassociatedcheilitis AT umranoner lipmesotherapywithdexpanthenolasanovelapproachtopreventisotretinoinassociatedcheilitis |