High visceral adipose tissue area is independently associated with early allograft dysfunction in liver transplantation recipients: a propensity score analysis
Abstract Objectives To evaluate the association between adipose tissue distribution and early allograft dysfunction (EAD) in liver transplantation (LT) recipients. Methods A total of 175 patients who received LT from April 2015 to September 2020 were enrolled in this retrospective study. The areas o...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2022-10-01
|
| Series: | Insights into Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13244-022-01302-8 |
| _version_ | 1811238926555283456 |
|---|---|
| author | Guanjie Yuan Shichao Li Ping Liang Gen Chen Yan Luo Yaqi Shen Xuemei Hu Daoyu Hu Jiali Li Zhen Li |
| author_facet | Guanjie Yuan Shichao Li Ping Liang Gen Chen Yan Luo Yaqi Shen Xuemei Hu Daoyu Hu Jiali Li Zhen Li |
| author_sort | Guanjie Yuan |
| collection | DOAJ |
| description | Abstract Objectives To evaluate the association between adipose tissue distribution and early allograft dysfunction (EAD) in liver transplantation (LT) recipients. Methods A total of 175 patients who received LT from April 2015 to September 2020 were enrolled in this retrospective study. The areas of abdominal adipose tissue and skeletal muscle of all patients were measured based on the preoperative CT images. The appropriate statistical methods including the propensity score-matched (PSM) analysis were performed to identify the association between adipose tissue distribution and EAD. Results Of 175 LT recipients, 55 patients (31.4%) finally developed EAD. The multivariate logistic analysis revealed that preoperative serum albumin (odds ratio (OR) 0.34, 95% confidence interval (CI) 0.17–0.70), platelet–lymphocyte ratio (OR 2.35, 95% CI 1.18–4.79), and visceral adipose tissue (VAT) area (OR 3.17, 95% CI 1.56–6.43) were independent associated with EAD. After PSM analysis, VAT area was still significantly associated with EAD (OR 3.95, 95% CI 1.16–13.51). In survival analysis, no significant difference was identified in one-year graft failure (log-rank: p = 0.487), and conversely result was identified in overall survival (OS) (log-rank: p = 0.012; hazard ratio (HR) 4.10, 95% CI 1.27–13.16). Conclusions LT recipients with high VAT area have higher risk for the occurrence of EAD, and high VAT area might have certain clinical value for predicting the poor OS of patients. For LT candidates with large amount of VAT, the clinicians can take clinical interventions by suggesting physical and nutritional treatments to improve outcomes after LT. |
| first_indexed | 2024-04-12T12:50:52Z |
| format | Article |
| id | doaj.art-b8f94e24d6e14d98b207589b9f120c3e |
| institution | Directory Open Access Journal |
| issn | 1869-4101 |
| language | English |
| last_indexed | 2024-04-12T12:50:52Z |
| publishDate | 2022-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Insights into Imaging |
| spelling | doaj.art-b8f94e24d6e14d98b207589b9f120c3e2022-12-22T03:32:29ZengSpringerOpenInsights into Imaging1869-41012022-10-0113111210.1186/s13244-022-01302-8High visceral adipose tissue area is independently associated with early allograft dysfunction in liver transplantation recipients: a propensity score analysisGuanjie Yuan0Shichao Li1Ping Liang2Gen Chen3Yan Luo4Yaqi Shen5Xuemei Hu6Daoyu Hu7Jiali Li8Zhen Li9Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Objectives To evaluate the association between adipose tissue distribution and early allograft dysfunction (EAD) in liver transplantation (LT) recipients. Methods A total of 175 patients who received LT from April 2015 to September 2020 were enrolled in this retrospective study. The areas of abdominal adipose tissue and skeletal muscle of all patients were measured based on the preoperative CT images. The appropriate statistical methods including the propensity score-matched (PSM) analysis were performed to identify the association between adipose tissue distribution and EAD. Results Of 175 LT recipients, 55 patients (31.4%) finally developed EAD. The multivariate logistic analysis revealed that preoperative serum albumin (odds ratio (OR) 0.34, 95% confidence interval (CI) 0.17–0.70), platelet–lymphocyte ratio (OR 2.35, 95% CI 1.18–4.79), and visceral adipose tissue (VAT) area (OR 3.17, 95% CI 1.56–6.43) were independent associated with EAD. After PSM analysis, VAT area was still significantly associated with EAD (OR 3.95, 95% CI 1.16–13.51). In survival analysis, no significant difference was identified in one-year graft failure (log-rank: p = 0.487), and conversely result was identified in overall survival (OS) (log-rank: p = 0.012; hazard ratio (HR) 4.10, 95% CI 1.27–13.16). Conclusions LT recipients with high VAT area have higher risk for the occurrence of EAD, and high VAT area might have certain clinical value for predicting the poor OS of patients. For LT candidates with large amount of VAT, the clinicians can take clinical interventions by suggesting physical and nutritional treatments to improve outcomes after LT.https://doi.org/10.1186/s13244-022-01302-8Tomography (X-ray computed)Body compositionLiver transplantationAllograftPropensity score |
| spellingShingle | Guanjie Yuan Shichao Li Ping Liang Gen Chen Yan Luo Yaqi Shen Xuemei Hu Daoyu Hu Jiali Li Zhen Li High visceral adipose tissue area is independently associated with early allograft dysfunction in liver transplantation recipients: a propensity score analysis Insights into Imaging Tomography (X-ray computed) Body composition Liver transplantation Allograft Propensity score |
| title | High visceral adipose tissue area is independently associated with early allograft dysfunction in liver transplantation recipients: a propensity score analysis |
| title_full | High visceral adipose tissue area is independently associated with early allograft dysfunction in liver transplantation recipients: a propensity score analysis |
| title_fullStr | High visceral adipose tissue area is independently associated with early allograft dysfunction in liver transplantation recipients: a propensity score analysis |
| title_full_unstemmed | High visceral adipose tissue area is independently associated with early allograft dysfunction in liver transplantation recipients: a propensity score analysis |
| title_short | High visceral adipose tissue area is independently associated with early allograft dysfunction in liver transplantation recipients: a propensity score analysis |
| title_sort | high visceral adipose tissue area is independently associated with early allograft dysfunction in liver transplantation recipients a propensity score analysis |
| topic | Tomography (X-ray computed) Body composition Liver transplantation Allograft Propensity score |
| url | https://doi.org/10.1186/s13244-022-01302-8 |
| work_keys_str_mv | AT guanjieyuan highvisceraladiposetissueareaisindependentlyassociatedwithearlyallograftdysfunctioninlivertransplantationrecipientsapropensityscoreanalysis AT shichaoli highvisceraladiposetissueareaisindependentlyassociatedwithearlyallograftdysfunctioninlivertransplantationrecipientsapropensityscoreanalysis AT pingliang highvisceraladiposetissueareaisindependentlyassociatedwithearlyallograftdysfunctioninlivertransplantationrecipientsapropensityscoreanalysis AT genchen highvisceraladiposetissueareaisindependentlyassociatedwithearlyallograftdysfunctioninlivertransplantationrecipientsapropensityscoreanalysis AT yanluo highvisceraladiposetissueareaisindependentlyassociatedwithearlyallograftdysfunctioninlivertransplantationrecipientsapropensityscoreanalysis AT yaqishen highvisceraladiposetissueareaisindependentlyassociatedwithearlyallograftdysfunctioninlivertransplantationrecipientsapropensityscoreanalysis AT xuemeihu highvisceraladiposetissueareaisindependentlyassociatedwithearlyallograftdysfunctioninlivertransplantationrecipientsapropensityscoreanalysis AT daoyuhu highvisceraladiposetissueareaisindependentlyassociatedwithearlyallograftdysfunctioninlivertransplantationrecipientsapropensityscoreanalysis AT jialili highvisceraladiposetissueareaisindependentlyassociatedwithearlyallograftdysfunctioninlivertransplantationrecipientsapropensityscoreanalysis AT zhenli highvisceraladiposetissueareaisindependentlyassociatedwithearlyallograftdysfunctioninlivertransplantationrecipientsapropensityscoreanalysis |