Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study
Background Literature with regard to coronavirus disease 2019 (COVID-19) associated morbidities and the risk factors for death are still emerging. In this study, we investigated the presence of kidney damage markers and their predictive value for survival among hospitalized subjects with COVID-19. M...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0886022X.2022.2032743 |
| _version_ | 1828882489720963072 |
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| author | Mustafa Zafer Temiz Ibrahim Hacibey Ramazan Omer Yazar Mehmet Salih Sevdi Suat Hayri Kucuk Gizem Alkurt Levent Doganay Gizem Dinler Doganay Muhammet Murat Dincer Emrah Yuruk Kerem Erkalp Ahmet Yaser Muslumanoglu |
| author_facet | Mustafa Zafer Temiz Ibrahim Hacibey Ramazan Omer Yazar Mehmet Salih Sevdi Suat Hayri Kucuk Gizem Alkurt Levent Doganay Gizem Dinler Doganay Muhammet Murat Dincer Emrah Yuruk Kerem Erkalp Ahmet Yaser Muslumanoglu |
| author_sort | Mustafa Zafer Temiz |
| collection | DOAJ |
| description | Background Literature with regard to coronavirus disease 2019 (COVID-19) associated morbidities and the risk factors for death are still emerging. In this study, we investigated the presence of kidney damage markers and their predictive value for survival among hospitalized subjects with COVID-19. Methods Forty-seven participants was included and grouped as: ‘COVID-19 patients before treatment’, ‘COVID-19 patients after treatment’, ‘COVID-19 patients under treatment in intensive care unit (ICU)’, and ‘controls’. Kidney function tests and several kidney injury biomarkers were compared between the groups. Cumulative rates of death from COVID-19 were determined using the Kaplan–Meier method. The associations between covariates including kidney injury markers and death from COVID-19 were examined, as well. Results Serum creatinine and cystatin C levels, urine Kidney Injury Molecule-1 (KIM-1)/creatinine ratio, and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), CKD-EPI cystatin C, and CKD-EPI creatinine–cystatin C levels demonstrated significant difference among the groups. The most significant difference was noted between the groups ‘COVID-19 patients before treatment’ and ‘COVID-19 patients under treatment in ICU’. Advancing age, proteinuria, elevated serum cystatin C, and urine KIM-1/creatinine ratio were all significant univariate correlates of death (p < 0.05, for all). However, only elevated urine KIM-1/creatinine ratio retained significance in an age, sex, and comorbidities adjusted multivariable Cox regression (OR 6.11; 95% CI: 1.22–30.53; p = 0.02), whereas serum cystatin C showing only a statistically non-significant trend (OR 1.42; 95% CI: 0.00–2.52; p = 0.09). Conclusions Our findings clearly demonstrated the acute kidney injury related to COVID-19. Moreover, urine KIM-1/creatinine ratio was associated with COVID-19 specific death. |
| first_indexed | 2024-12-13T10:30:34Z |
| format | Article |
| id | doaj.art-b8fa821e52ac45d898971f9cabea8f73 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-13T10:30:34Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-b8fa821e52ac45d898971f9cabea8f732022-12-21T23:50:53ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492022-12-0144123324010.1080/0886022X.2022.20327432032743Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot studyMustafa Zafer Temiz0Ibrahim Hacibey1Ramazan Omer Yazar2Mehmet Salih Sevdi3Suat Hayri Kucuk4Gizem Alkurt5Levent Doganay6Gizem Dinler Doganay7Muhammet Murat Dincer8Emrah Yuruk9Kerem Erkalp10Ahmet Yaser Muslumanoglu11Department of Urology, Bagcilar Training and Research HospitalDepartment of Urology, Bagcilar Training and Research HospitalDepartment of Urology, Bagcilar Training and Research HospitalDepartment of Anesthesiology and Reanimation, Bagcilar Training and Research HospitalDepartment of Biochemistry, Bagcilar Training and Research HospitalGenomic Laboratory (GLAB), Umraniye Training and Research Hospital, ElmalikentGenomic Laboratory (GLAB), Umraniye Training and Research Hospital, ElmalikentDepartment of Molecular Biology and Genetics, Istanbul Technical UniversityDepartment of Urology, Bagcilar Training and Research HospitalDepartment of Urology, BHT Clinic Istanbul Tema HospitalDepartment of Anesthesiology and Reanimation, Bagcilar Training and Research HospitalDepartment of Urology, Bagcilar Training and Research HospitalBackground Literature with regard to coronavirus disease 2019 (COVID-19) associated morbidities and the risk factors for death are still emerging. In this study, we investigated the presence of kidney damage markers and their predictive value for survival among hospitalized subjects with COVID-19. Methods Forty-seven participants was included and grouped as: ‘COVID-19 patients before treatment’, ‘COVID-19 patients after treatment’, ‘COVID-19 patients under treatment in intensive care unit (ICU)’, and ‘controls’. Kidney function tests and several kidney injury biomarkers were compared between the groups. Cumulative rates of death from COVID-19 were determined using the Kaplan–Meier method. The associations between covariates including kidney injury markers and death from COVID-19 were examined, as well. Results Serum creatinine and cystatin C levels, urine Kidney Injury Molecule-1 (KIM-1)/creatinine ratio, and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), CKD-EPI cystatin C, and CKD-EPI creatinine–cystatin C levels demonstrated significant difference among the groups. The most significant difference was noted between the groups ‘COVID-19 patients before treatment’ and ‘COVID-19 patients under treatment in ICU’. Advancing age, proteinuria, elevated serum cystatin C, and urine KIM-1/creatinine ratio were all significant univariate correlates of death (p < 0.05, for all). However, only elevated urine KIM-1/creatinine ratio retained significance in an age, sex, and comorbidities adjusted multivariable Cox regression (OR 6.11; 95% CI: 1.22–30.53; p = 0.02), whereas serum cystatin C showing only a statistically non-significant trend (OR 1.42; 95% CI: 0.00–2.52; p = 0.09). Conclusions Our findings clearly demonstrated the acute kidney injury related to COVID-19. Moreover, urine KIM-1/creatinine ratio was associated with COVID-19 specific death.http://dx.doi.org/10.1080/0886022X.2022.2032743covid-19kidneyacute kidney injurysurvival analysis |
| spellingShingle | Mustafa Zafer Temiz Ibrahim Hacibey Ramazan Omer Yazar Mehmet Salih Sevdi Suat Hayri Kucuk Gizem Alkurt Levent Doganay Gizem Dinler Doganay Muhammet Murat Dincer Emrah Yuruk Kerem Erkalp Ahmet Yaser Muslumanoglu Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study Renal Failure covid-19 kidney acute kidney injury survival analysis |
| title | Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study |
| title_full | Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study |
| title_fullStr | Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study |
| title_full_unstemmed | Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study |
| title_short | Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study |
| title_sort | altered kidney function induced by sars cov 2 infection and acute kidney damage markers predict survival outcomes of covid 19 patients a prospective pilot study |
| topic | covid-19 kidney acute kidney injury survival analysis |
| url | http://dx.doi.org/10.1080/0886022X.2022.2032743 |
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