Atypical adenomatous hyperplasia (adenosis) of the prostate: a case report with review of the literature
<p>Abstract</p> <p>A 62-year-old male presented with symptoms of urinary obstruction and elevated serum prostate-specific antigen level of 3.61 ng/mL. Prostate needle biopsies showed benign prostatic tissue with a focus of crowded glands with minimal cytological atypia, fairly well...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-08-01
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| Series: | Diagnostic Pathology |
| Online Access: | http://www.diagnosticpathology.org/content/3/1/34 |
| _version_ | 1818143197542481920 |
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| author | Parwani Anil V Armah Henry B |
| author_facet | Parwani Anil V Armah Henry B |
| author_sort | Parwani Anil V |
| collection | DOAJ |
| description | <p>Abstract</p> <p>A 62-year-old male presented with symptoms of urinary obstruction and elevated serum prostate-specific antigen level of 3.61 ng/mL. Prostate needle biopsies showed benign prostatic tissue with a focus of crowded glands with minimal cytological atypia, fairly well-circumscribed with infiltrative appearance of glands at the edges. This focus had both small and larger glands with similar histological features. This focus was strongly positive for alpha-methylacyl-coenzyme A-racemase (AMACR), but showed scattered patchy staining with basal cell markers (p63 and CK903/34βE12). Hence, the final histologic diagnosis was benign prostatic tissue with a focus of florid adenosis. Two subsequent follow-up prostate needle biopsies performed six and 12 months later both showed benign prostatic tissue with atrophic changes. This case highlights the utility of these three immunostains (AMACR, p63 and CK903/34βE12) in the accurate diagnosis of adenosis of the prostate on needle biopsy, and avoiding its misinterpretation as prostate adenocarcinoma.</p> |
| first_indexed | 2024-12-11T11:27:51Z |
| format | Article |
| id | doaj.art-b8fac892e8a14aef8ee82af011fc9b48 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-11T11:27:51Z |
| publishDate | 2008-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-b8fac892e8a14aef8ee82af011fc9b482022-12-22T01:08:58ZengBMCDiagnostic Pathology1746-15962008-08-01313410.1186/1746-1596-3-34Atypical adenomatous hyperplasia (adenosis) of the prostate: a case report with review of the literatureParwani Anil VArmah Henry B<p>Abstract</p> <p>A 62-year-old male presented with symptoms of urinary obstruction and elevated serum prostate-specific antigen level of 3.61 ng/mL. Prostate needle biopsies showed benign prostatic tissue with a focus of crowded glands with minimal cytological atypia, fairly well-circumscribed with infiltrative appearance of glands at the edges. This focus had both small and larger glands with similar histological features. This focus was strongly positive for alpha-methylacyl-coenzyme A-racemase (AMACR), but showed scattered patchy staining with basal cell markers (p63 and CK903/34βE12). Hence, the final histologic diagnosis was benign prostatic tissue with a focus of florid adenosis. Two subsequent follow-up prostate needle biopsies performed six and 12 months later both showed benign prostatic tissue with atrophic changes. This case highlights the utility of these three immunostains (AMACR, p63 and CK903/34βE12) in the accurate diagnosis of adenosis of the prostate on needle biopsy, and avoiding its misinterpretation as prostate adenocarcinoma.</p>http://www.diagnosticpathology.org/content/3/1/34 |
| spellingShingle | Parwani Anil V Armah Henry B Atypical adenomatous hyperplasia (adenosis) of the prostate: a case report with review of the literature Diagnostic Pathology |
| title | Atypical adenomatous hyperplasia (adenosis) of the prostate: a case report with review of the literature |
| title_full | Atypical adenomatous hyperplasia (adenosis) of the prostate: a case report with review of the literature |
| title_fullStr | Atypical adenomatous hyperplasia (adenosis) of the prostate: a case report with review of the literature |
| title_full_unstemmed | Atypical adenomatous hyperplasia (adenosis) of the prostate: a case report with review of the literature |
| title_short | Atypical adenomatous hyperplasia (adenosis) of the prostate: a case report with review of the literature |
| title_sort | atypical adenomatous hyperplasia adenosis of the prostate a case report with review of the literature |
| url | http://www.diagnosticpathology.org/content/3/1/34 |
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