A single centre experience of squamous cell carcinoma of the upper limb requiring digital or hand amputation and review of literature
Squamous cell carcinoma (SCC) is one of the most common primary malignancies affecting the upper limb. A range of treatment options exist for its management; amputation being indicated under certain instances. This is the first comprehensive case series and review of the literature reporting outcome...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-06-01
|
| Series: | JPRAS Open |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352587819300014 |
| _version_ | 1818884916028375040 |
|---|---|
| author | Leela Sayed Avinash K. Deodhar Reena Agarwal |
| author_facet | Leela Sayed Avinash K. Deodhar Reena Agarwal |
| author_sort | Leela Sayed |
| collection | DOAJ |
| description | Squamous cell carcinoma (SCC) is one of the most common primary malignancies affecting the upper limb. A range of treatment options exist for its management; amputation being indicated under certain instances. This is the first comprehensive case series and review of the literature reporting outcomes following amputation of the affected region for treatment of upper extremity SCC. We present a series of six patients with squamous cell carcinoma of the upper limb that required amputation alongside that of data from literature review. Patient demographics, risk factors, tumour characteristics and rates of recurrence, metastasis and mortality were recorded. A total of 45 patients with 49 histologically confirmed squamous cell carcinomas were identified from case series and literature review. Patients presenting with upper limb SCC were predominantly male and in their sixth decade of life. Mean follow up time was 30.5 months and the overall recurrence and metastatic rates were 8.2% and 14.3%, respectively. Mortality was 14.3% however only 6.1% was related to SCC metastasis. Rates of recurrence and metastasis are higher for SCCs affecting the hand as compared to other body sites. Furthermore, different regions of the hand appear to behave differently. SCC affecting the nail unit has a high recurrence and a low metastatic rate, whereas, SCC involving the palm and webspaces are aggressive and this is true despite amputation of the affected site. Keywords: Squamous cell carcinoma, Upper limb, Upper extremity, Hand, Digits |
| first_indexed | 2024-12-19T15:57:08Z |
| format | Article |
| id | doaj.art-b8fba6d591714570acb85f86e70b0ebc |
| institution | Directory Open Access Journal |
| issn | 2352-5878 |
| language | English |
| last_indexed | 2024-12-19T15:57:08Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JPRAS Open |
| spelling | doaj.art-b8fba6d591714570acb85f86e70b0ebc2022-12-21T20:15:04ZengElsevierJPRAS Open2352-58782019-06-01204358A single centre experience of squamous cell carcinoma of the upper limb requiring digital or hand amputation and review of literatureLeela Sayed0Avinash K. Deodhar1Reena Agarwal2Corresponding author.; Department of Plastic Surgery, University Hospitals of Leicester, Infirmary Square, Leicester LE1 5WW, United KingdomDepartment of Plastic Surgery, University Hospitals of Leicester, Infirmary Square, Leicester LE1 5WW, United KingdomDepartment of Plastic Surgery, University Hospitals of Leicester, Infirmary Square, Leicester LE1 5WW, United KingdomSquamous cell carcinoma (SCC) is one of the most common primary malignancies affecting the upper limb. A range of treatment options exist for its management; amputation being indicated under certain instances. This is the first comprehensive case series and review of the literature reporting outcomes following amputation of the affected region for treatment of upper extremity SCC. We present a series of six patients with squamous cell carcinoma of the upper limb that required amputation alongside that of data from literature review. Patient demographics, risk factors, tumour characteristics and rates of recurrence, metastasis and mortality were recorded. A total of 45 patients with 49 histologically confirmed squamous cell carcinomas were identified from case series and literature review. Patients presenting with upper limb SCC were predominantly male and in their sixth decade of life. Mean follow up time was 30.5 months and the overall recurrence and metastatic rates were 8.2% and 14.3%, respectively. Mortality was 14.3% however only 6.1% was related to SCC metastasis. Rates of recurrence and metastasis are higher for SCCs affecting the hand as compared to other body sites. Furthermore, different regions of the hand appear to behave differently. SCC affecting the nail unit has a high recurrence and a low metastatic rate, whereas, SCC involving the palm and webspaces are aggressive and this is true despite amputation of the affected site. Keywords: Squamous cell carcinoma, Upper limb, Upper extremity, Hand, Digitshttp://www.sciencedirect.com/science/article/pii/S2352587819300014 |
| spellingShingle | Leela Sayed Avinash K. Deodhar Reena Agarwal A single centre experience of squamous cell carcinoma of the upper limb requiring digital or hand amputation and review of literature JPRAS Open |
| title | A single centre experience of squamous cell carcinoma of the upper limb requiring digital or hand amputation and review of literature |
| title_full | A single centre experience of squamous cell carcinoma of the upper limb requiring digital or hand amputation and review of literature |
| title_fullStr | A single centre experience of squamous cell carcinoma of the upper limb requiring digital or hand amputation and review of literature |
| title_full_unstemmed | A single centre experience of squamous cell carcinoma of the upper limb requiring digital or hand amputation and review of literature |
| title_short | A single centre experience of squamous cell carcinoma of the upper limb requiring digital or hand amputation and review of literature |
| title_sort | single centre experience of squamous cell carcinoma of the upper limb requiring digital or hand amputation and review of literature |
| url | http://www.sciencedirect.com/science/article/pii/S2352587819300014 |
| work_keys_str_mv | AT leelasayed asinglecentreexperienceofsquamouscellcarcinomaoftheupperlimbrequiringdigitalorhandamputationandreviewofliterature AT avinashkdeodhar asinglecentreexperienceofsquamouscellcarcinomaoftheupperlimbrequiringdigitalorhandamputationandreviewofliterature AT reenaagarwal asinglecentreexperienceofsquamouscellcarcinomaoftheupperlimbrequiringdigitalorhandamputationandreviewofliterature AT leelasayed singlecentreexperienceofsquamouscellcarcinomaoftheupperlimbrequiringdigitalorhandamputationandreviewofliterature AT avinashkdeodhar singlecentreexperienceofsquamouscellcarcinomaoftheupperlimbrequiringdigitalorhandamputationandreviewofliterature AT reenaagarwal singlecentreexperienceofsquamouscellcarcinomaoftheupperlimbrequiringdigitalorhandamputationandreviewofliterature |