BID mediates oxygen-glucose deprivation-induced neuronal injury in organotypic hippocampal slice cultures and modulates tissue inflammation in a transient focal cerebral ischemia model without changing lesion volu

BID mediates oxygen-glucose deprivation-induced neuronal injury in organotypic hippocampal slice cultures and modulates tissue inflammation in a transient focal cerebral ischemia model without changing lesion volu

The BH3 interacting-domain death agonist (BID) is a pro-apoptotic protein involved in death receptor-induced and mitochondria-mediated apoptosis. Recently, it has also been suggested that BID is involved in the regulation of inflammatory responses in the central nervous system. We found that BID def...

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Bibliographic Details
Main Authors: Nellie Anne Martin, Helena eBonner, Maria Louise Elkjær, Beatrice eD'Orsi, Gang eChen, Hans-Georg eKönig, Martina eSvensson, Tomas eDeierborg, Shona ePfeiffer, Jochen H.M. Prehn, Kate Lykke Lambertsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Inflammation
BID
focal cerebral ischemia
neuronal injury
Organotypic hippocampal slice cultures
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00014/full

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