VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and Diseases
The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for cellular fate. In addition to control over energy sources and metabolism, the protein also regulates epigenomic elements and a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/11/1485 |
| _version_ | 1797549764983652352 |
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| author | Varda Shoshan-Barmatz Anna Shteinfer-Kuzmine Ankit Verma |
| author_facet | Varda Shoshan-Barmatz Anna Shteinfer-Kuzmine Ankit Verma |
| author_sort | Varda Shoshan-Barmatz |
| collection | DOAJ |
| description | The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for cellular fate. In addition to control over energy sources and metabolism, the protein also regulates epigenomic elements and apoptosis via mediating the release of apoptotic proteins from the mitochondria. Apoptotic and pathological conditions, as well as certain viruses, induce cell death by inducing VDAC1 overexpression leading to oligomerization, and the formation of a large channel within the VDAC1 homo-oligomer. This then permits the release of pro-apoptotic proteins from the mitochondria and subsequent apoptosis. Mitochondrial DNA can also be released through this channel, which triggers type-Ι interferon responses. VDAC1 also participates in endoplasmic reticulum (ER)-mitochondria cross-talk, and in the regulation of autophagy, and inflammation. Its location in the outer mitochondrial membrane, makes VDAC1 ideally placed to interact with over 100 proteins, and to orchestrate the interaction of mitochondrial and cellular activities through a number of signaling pathways. Here, we provide insights into the multiple functions of VDAC1 and describe its involvement in several diseases, which demonstrate the potential of this protein as a druggable target in a wide variety of pathologies, including cancer. |
| first_indexed | 2024-03-10T15:20:04Z |
| format | Article |
| id | doaj.art-b8fcc215f93e4abea3625c29e162a128 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T15:20:04Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-b8fcc215f93e4abea3625c29e162a1282023-11-20T18:38:09ZengMDPI AGBiomolecules2218-273X2020-10-011011148510.3390/biom10111485VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and DiseasesVarda Shoshan-Barmatz0Anna Shteinfer-Kuzmine1Ankit Verma2Department of Life Sciences and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, IsraelDepartment of Life Sciences and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, IsraelDepartment of Life Sciences and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, IsraelThe voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for cellular fate. In addition to control over energy sources and metabolism, the protein also regulates epigenomic elements and apoptosis via mediating the release of apoptotic proteins from the mitochondria. Apoptotic and pathological conditions, as well as certain viruses, induce cell death by inducing VDAC1 overexpression leading to oligomerization, and the formation of a large channel within the VDAC1 homo-oligomer. This then permits the release of pro-apoptotic proteins from the mitochondria and subsequent apoptosis. Mitochondrial DNA can also be released through this channel, which triggers type-Ι interferon responses. VDAC1 also participates in endoplasmic reticulum (ER)-mitochondria cross-talk, and in the regulation of autophagy, and inflammation. Its location in the outer mitochondrial membrane, makes VDAC1 ideally placed to interact with over 100 proteins, and to orchestrate the interaction of mitochondrial and cellular activities through a number of signaling pathways. Here, we provide insights into the multiple functions of VDAC1 and describe its involvement in several diseases, which demonstrate the potential of this protein as a druggable target in a wide variety of pathologies, including cancer.https://www.mdpi.com/2218-273X/10/11/1485apoptosiscancerdiseasesmetabolismmitochondriaVDAC1 |
| spellingShingle | Varda Shoshan-Barmatz Anna Shteinfer-Kuzmine Ankit Verma VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and Diseases Biomolecules apoptosis cancer diseases metabolism mitochondria VDAC1 |
| title | VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and Diseases |
| title_full | VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and Diseases |
| title_fullStr | VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and Diseases |
| title_full_unstemmed | VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and Diseases |
| title_short | VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and Diseases |
| title_sort | vdac1 at the intersection of cell metabolism apoptosis and diseases |
| topic | apoptosis cancer diseases metabolism mitochondria VDAC1 |
| url | https://www.mdpi.com/2218-273X/10/11/1485 |
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