Preclinical orofacial pain assays and measures and chronic primary orofacial pain research: where we are and where we need to go
Chronic primary orofacial pain (OFP) conditions such as painful temporomandibular disorders (pTMDs; i.e., myofascial pain and arthralgia), idiopathic trigeminal neuralgia (TN), and burning mouth syndrome (BMS) are seemingly idiopathic, but evidence support complex and multifactorial etiology and pat...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Pain Research |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpain.2023.1150749/full |
| _version_ | 1797821517245972480 |
|---|---|
| author | Shirin Sadighparvar Shirin Sadighparvar Faez Saleh Al-Hamed Reza Sharif-Naeini Reza Sharif-Naeini Carolina Beraldo Meloto Carolina Beraldo Meloto |
| author_facet | Shirin Sadighparvar Shirin Sadighparvar Faez Saleh Al-Hamed Reza Sharif-Naeini Reza Sharif-Naeini Carolina Beraldo Meloto Carolina Beraldo Meloto |
| author_sort | Shirin Sadighparvar |
| collection | DOAJ |
| description | Chronic primary orofacial pain (OFP) conditions such as painful temporomandibular disorders (pTMDs; i.e., myofascial pain and arthralgia), idiopathic trigeminal neuralgia (TN), and burning mouth syndrome (BMS) are seemingly idiopathic, but evidence support complex and multifactorial etiology and pathophysiology. Important fragments of this complex array of factors have been identified over the years largely with the help of preclinical studies. However, findings have yet to translate into better pain care for chronic OFP patients. The need to develop preclinical assays that better simulate the etiology, pathophysiology, and clinical symptoms of OFP patients and to assess OFP measures consistent with their clinical symptoms is a challenge that needs to be overcome to support this translation process. In this review, we describe rodent assays and OFP pain measures that can be used in support of chronic primary OFP research, in specific pTMDs, TN, and BMS. We discuss their suitability and limitations considering the current knowledge of the etiology and pathophysiology of these conditions and suggest possible future directions. Our goal is to foster the development of innovative animal models with greater translatability and potential to lead to better care for patients living with chronic primary OFP. |
| first_indexed | 2024-03-13T09:53:50Z |
| format | Article |
| id | doaj.art-b8fd29388167453fbf304efceb58ecab |
| institution | Directory Open Access Journal |
| issn | 2673-561X |
| language | English |
| last_indexed | 2024-03-13T09:53:50Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pain Research |
| spelling | doaj.art-b8fd29388167453fbf304efceb58ecab2023-05-24T04:53:20ZengFrontiers Media S.A.Frontiers in Pain Research2673-561X2023-05-01410.3389/fpain.2023.11507491150749Preclinical orofacial pain assays and measures and chronic primary orofacial pain research: where we are and where we need to goShirin Sadighparvar0Shirin Sadighparvar1Faez Saleh Al-Hamed2Reza Sharif-Naeini3Reza Sharif-Naeini4Carolina Beraldo Meloto5Carolina Beraldo Meloto6Integrated Program in Neuroscience, McGill University, Montreal, QC, CanadaThe Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, CanadaCollege of Dental Medicine, QU Health, Qatar University, Doha, QatarThe Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, CanadaDepartment of Physiology and Cell Information Systems, McGill University, Montreal, QC, CanadaThe Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, CanadaFaculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, CanadaChronic primary orofacial pain (OFP) conditions such as painful temporomandibular disorders (pTMDs; i.e., myofascial pain and arthralgia), idiopathic trigeminal neuralgia (TN), and burning mouth syndrome (BMS) are seemingly idiopathic, but evidence support complex and multifactorial etiology and pathophysiology. Important fragments of this complex array of factors have been identified over the years largely with the help of preclinical studies. However, findings have yet to translate into better pain care for chronic OFP patients. The need to develop preclinical assays that better simulate the etiology, pathophysiology, and clinical symptoms of OFP patients and to assess OFP measures consistent with their clinical symptoms is a challenge that needs to be overcome to support this translation process. In this review, we describe rodent assays and OFP pain measures that can be used in support of chronic primary OFP research, in specific pTMDs, TN, and BMS. We discuss their suitability and limitations considering the current knowledge of the etiology and pathophysiology of these conditions and suggest possible future directions. Our goal is to foster the development of innovative animal models with greater translatability and potential to lead to better care for patients living with chronic primary OFP.https://www.frontiersin.org/articles/10.3389/fpain.2023.1150749/fullorofacial painprimary painpreclinical studies & animal modelstemporomandibular disordertrigeminal neuralgiaburning mouth syndrome (BMS) |
| spellingShingle | Shirin Sadighparvar Shirin Sadighparvar Faez Saleh Al-Hamed Reza Sharif-Naeini Reza Sharif-Naeini Carolina Beraldo Meloto Carolina Beraldo Meloto Preclinical orofacial pain assays and measures and chronic primary orofacial pain research: where we are and where we need to go Frontiers in Pain Research orofacial pain primary pain preclinical studies & animal models temporomandibular disorder trigeminal neuralgia burning mouth syndrome (BMS) |
| title | Preclinical orofacial pain assays and measures and chronic primary orofacial pain research: where we are and where we need to go |
| title_full | Preclinical orofacial pain assays and measures and chronic primary orofacial pain research: where we are and where we need to go |
| title_fullStr | Preclinical orofacial pain assays and measures and chronic primary orofacial pain research: where we are and where we need to go |
| title_full_unstemmed | Preclinical orofacial pain assays and measures and chronic primary orofacial pain research: where we are and where we need to go |
| title_short | Preclinical orofacial pain assays and measures and chronic primary orofacial pain research: where we are and where we need to go |
| title_sort | preclinical orofacial pain assays and measures and chronic primary orofacial pain research where we are and where we need to go |
| topic | orofacial pain primary pain preclinical studies & animal models temporomandibular disorder trigeminal neuralgia burning mouth syndrome (BMS) |
| url | https://www.frontiersin.org/articles/10.3389/fpain.2023.1150749/full |
| work_keys_str_mv | AT shirinsadighparvar preclinicalorofacialpainassaysandmeasuresandchronicprimaryorofacialpainresearchwhereweareandwhereweneedtogo AT shirinsadighparvar preclinicalorofacialpainassaysandmeasuresandchronicprimaryorofacialpainresearchwhereweareandwhereweneedtogo AT faezsalehalhamed preclinicalorofacialpainassaysandmeasuresandchronicprimaryorofacialpainresearchwhereweareandwhereweneedtogo AT rezasharifnaeini preclinicalorofacialpainassaysandmeasuresandchronicprimaryorofacialpainresearchwhereweareandwhereweneedtogo AT rezasharifnaeini preclinicalorofacialpainassaysandmeasuresandchronicprimaryorofacialpainresearchwhereweareandwhereweneedtogo AT carolinaberaldomeloto preclinicalorofacialpainassaysandmeasuresandchronicprimaryorofacialpainresearchwhereweareandwhereweneedtogo AT carolinaberaldomeloto preclinicalorofacialpainassaysandmeasuresandchronicprimaryorofacialpainresearchwhereweareandwhereweneedtogo |