Apigenin Reduces NF-κB and Subsequent Cytokine Production as Protective Effect in a Rodent Animal Model of Lung Ischemia-Reperfusion Injury

Apigenin Reduces NF-κB and Subsequent Cytokine Production as Protective Effect in a Rodent Animal Model of Lung Ischemia-Reperfusion Injury

Purpose: Lung ischemia–reperfusion injury (LIRI) can complicate lung transplantation or cardiac surgery with cardiopulmonary bypass, increasing morbidity and mortality. In LIRI, pro-inflammatory cytokines are activated, reactive oxygen species are generated and nuclear factor-κB (NF-κB) is up-regula...

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Bibliographic Details
Main Authors: Ioannis Bougioukas, Vassilios Didilis, Alexander Emmert, Ahmad F Jebran, Regina Waldmann-Beushausen, Tomislav Stojanovic, Friedrich A. Schoendube, Bernhard C. Danner
Format: Article
Language:English
Published: Taylor & Francis Group 2018-03-01
Series:Journal of Investigative Surgery
Subjects:
apigenin
interleukins
lung ischemia-reperfusion injury
nf-κb, tnfα
Online Access:http://dx.doi.org/10.1080/08941939.2017.1296512

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