The Dynamics of Changes in the Concentration of IgG against the S1 Subunit in Polish Healthcare Workers in the Period from 1 to 12 Months after Injection, Including Four COVID-19 Vaccines
Background: The presented research made it possible to obtain the characteristics of changes in anti-SARS-CoV-2 IgG within one year of vaccination in healthcare workers. Materials and Methods: The research group consisted of 18,610 participants represented by medical and administration staff. IgG an...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/4/506 |
| _version_ | 1797443381061746688 |
|---|---|
| author | Monika Skorupa Joanna Szczepanek Agnieszka Goroncy Joanna Jarkiewicz-Tretyn Barbara Ptaszyńska Paweł Rajewski Wojciech Koper Krzysztof Pałgan Andrzej Tretyn |
| author_facet | Monika Skorupa Joanna Szczepanek Agnieszka Goroncy Joanna Jarkiewicz-Tretyn Barbara Ptaszyńska Paweł Rajewski Wojciech Koper Krzysztof Pałgan Andrzej Tretyn |
| author_sort | Monika Skorupa |
| collection | DOAJ |
| description | Background: The presented research made it possible to obtain the characteristics of changes in anti-SARS-CoV-2 IgG within one year of vaccination in healthcare workers. Materials and Methods: The research group consisted of 18,610 participants represented by medical and administration staff. IgG antibody concentrations were determined by ELISA. Results: At 5–8 months after full vaccination, the levels of anti-SARS-CoV-2 IgG with equal vaccines were similar. The exception was JNJ-78436735, for which IgG levels were significantly lower. In the 9th month after vaccination, an increase in the anti-SARS-CoV-2 IgG level, suggesting asymptomatic infection, was observed in a large group of participants. Significantly higher levels of anti-SARS-CoV-2 IgG antibodies were observed after the booster dose compared to the second dose. The increase in antibodies was observed already around the 5th day after the injection of the booster dose, and was maximized at approximately the 14th day. Conclusion: The cut-off date for protection against the disease seems to be the period 8–9 months from the vaccination for mRNA vaccines and 5–6 months for vector vaccines. The introduction of a booster dose was the right decision, which could have a real impact on restricting the further transmission of the virus. |
| first_indexed | 2024-03-09T12:55:12Z |
| format | Article |
| id | doaj.art-b900e09084cf4c96944d0e6b09cb0aca |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T12:55:12Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-b900e09084cf4c96944d0e6b09cb0aca2023-11-30T22:01:45ZengMDPI AGVaccines2076-393X2022-03-0110450610.3390/vaccines10040506The Dynamics of Changes in the Concentration of IgG against the S1 Subunit in Polish Healthcare Workers in the Period from 1 to 12 Months after Injection, Including Four COVID-19 VaccinesMonika Skorupa0Joanna Szczepanek1Agnieszka Goroncy2Joanna Jarkiewicz-Tretyn3Barbara Ptaszyńska4Paweł Rajewski5Wojciech Koper6Krzysztof Pałgan7Andrzej Tretyn8Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, 87-100 Torun, PolandCentre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University, 87-100 Torun, PolandFaculty of Mathematics and Computer Science, Nicolaus Copernicus University, 87-100 Torun, PolandNon-Public Health Care Centre, Cancer Genetics Laboratory, 87-100 Torun, PolandMarshal’s Office of the Kuyavian-Pomeranian Voivodeship, 87-100 Torun, PolandDepartment of Internal and Infectious Diseases, Provincial Infectious Disease Hospital, 85-067 Bydgoszcz, PolandThe Voivodeship Sanitary-Epidemiological Station in Bydgoszcz, 85-031 Bydgoszcz, PolandDepartment of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum, Nicolaus Copernicus University, 85-067 Bydgoszcz, PolandCentre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University, 87-100 Torun, PolandBackground: The presented research made it possible to obtain the characteristics of changes in anti-SARS-CoV-2 IgG within one year of vaccination in healthcare workers. Materials and Methods: The research group consisted of 18,610 participants represented by medical and administration staff. IgG antibody concentrations were determined by ELISA. Results: At 5–8 months after full vaccination, the levels of anti-SARS-CoV-2 IgG with equal vaccines were similar. The exception was JNJ-78436735, for which IgG levels were significantly lower. In the 9th month after vaccination, an increase in the anti-SARS-CoV-2 IgG level, suggesting asymptomatic infection, was observed in a large group of participants. Significantly higher levels of anti-SARS-CoV-2 IgG antibodies were observed after the booster dose compared to the second dose. The increase in antibodies was observed already around the 5th day after the injection of the booster dose, and was maximized at approximately the 14th day. Conclusion: The cut-off date for protection against the disease seems to be the period 8–9 months from the vaccination for mRNA vaccines and 5–6 months for vector vaccines. The introduction of a booster dose was the right decision, which could have a real impact on restricting the further transmission of the virus.https://www.mdpi.com/2076-393X/10/4/506SARS-CoV-2COVID-19vaccinationantibodiesBNT162b2mRNA-1273 |
| spellingShingle | Monika Skorupa Joanna Szczepanek Agnieszka Goroncy Joanna Jarkiewicz-Tretyn Barbara Ptaszyńska Paweł Rajewski Wojciech Koper Krzysztof Pałgan Andrzej Tretyn The Dynamics of Changes in the Concentration of IgG against the S1 Subunit in Polish Healthcare Workers in the Period from 1 to 12 Months after Injection, Including Four COVID-19 Vaccines Vaccines SARS-CoV-2 COVID-19 vaccination antibodies BNT162b2 mRNA-1273 |
| title | The Dynamics of Changes in the Concentration of IgG against the S1 Subunit in Polish Healthcare Workers in the Period from 1 to 12 Months after Injection, Including Four COVID-19 Vaccines |
| title_full | The Dynamics of Changes in the Concentration of IgG against the S1 Subunit in Polish Healthcare Workers in the Period from 1 to 12 Months after Injection, Including Four COVID-19 Vaccines |
| title_fullStr | The Dynamics of Changes in the Concentration of IgG against the S1 Subunit in Polish Healthcare Workers in the Period from 1 to 12 Months after Injection, Including Four COVID-19 Vaccines |
| title_full_unstemmed | The Dynamics of Changes in the Concentration of IgG against the S1 Subunit in Polish Healthcare Workers in the Period from 1 to 12 Months after Injection, Including Four COVID-19 Vaccines |
| title_short | The Dynamics of Changes in the Concentration of IgG against the S1 Subunit in Polish Healthcare Workers in the Period from 1 to 12 Months after Injection, Including Four COVID-19 Vaccines |
| title_sort | dynamics of changes in the concentration of igg against the s1 subunit in polish healthcare workers in the period from 1 to 12 months after injection including four covid 19 vaccines |
| topic | SARS-CoV-2 COVID-19 vaccination antibodies BNT162b2 mRNA-1273 |
| url | https://www.mdpi.com/2076-393X/10/4/506 |
| work_keys_str_mv | AT monikaskorupa thedynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT joannaszczepanek thedynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT agnieszkagoroncy thedynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT joannajarkiewicztretyn thedynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT barbaraptaszynska thedynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT pawełrajewski thedynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT wojciechkoper thedynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT krzysztofpałgan thedynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT andrzejtretyn thedynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT monikaskorupa dynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT joannaszczepanek dynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT agnieszkagoroncy dynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT joannajarkiewicztretyn dynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT barbaraptaszynska dynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT pawełrajewski dynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT wojciechkoper dynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT krzysztofpałgan dynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines AT andrzejtretyn dynamicsofchangesintheconcentrationofiggagainstthes1subunitinpolishhealthcareworkersintheperiodfrom1to12monthsafterinjectionincludingfourcovid19vaccines |