Multipotential Role of Growth Factor Mimetic Peptides for Osteochondral Tissue Engineering
Articular cartilage is characterized by a poor self-healing capacity due to its aneural and avascular nature. Once injured, it undergoes a series of catabolic processes which lead to its progressive degeneration and the onset of a severe chronic disease called osteoarthritis (OA). In OA, important a...
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| Language: | English |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/13/7388 |
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| author | Maria Giovanna Rizzo Nicoletta Palermo Ugo D’Amora Salvatore Oddo Salvatore Pietro Paolo Guglielmino Sabrina Conoci Marta Anna Szychlinska Giovanna Calabrese |
| author_facet | Maria Giovanna Rizzo Nicoletta Palermo Ugo D’Amora Salvatore Oddo Salvatore Pietro Paolo Guglielmino Sabrina Conoci Marta Anna Szychlinska Giovanna Calabrese |
| author_sort | Maria Giovanna Rizzo |
| collection | DOAJ |
| description | Articular cartilage is characterized by a poor self-healing capacity due to its aneural and avascular nature. Once injured, it undergoes a series of catabolic processes which lead to its progressive degeneration and the onset of a severe chronic disease called osteoarthritis (OA). In OA, important alterations of the morpho-functional organization occur in the cartilage extracellular matrix, involving all the nearby tissues, including the subchondral bone. Osteochondral engineering, based on a perfect combination of cells, biomaterials and biomolecules, is becoming increasingly successful for the regeneration of injured cartilage and underlying subchondral bone tissue. To this end, recently, several peptides have been explored as active molecules and enrichment motifs for the functionalization of biomaterials due to their ability to be easily chemically synthesized, as well as their tunable physico-chemical features, low immunogenicity issues and functional group modeling properties. In addition, they have shown a good aptitude to penetrate into the tissue due to their small size and stability at room temperature. In particular, growth-factor-derived peptides can play multiple functions in bone and cartilage repair, exhibiting chondrogenic/osteogenic differentiation properties. Among the most studied peptides, great attention has been paid to transforming growth factor-β and bone morphogenetic protein mimetic peptides, cell-penetrating peptides, cell-binding peptides, self-assembling peptides and extracellular matrix-derived peptides. Moreover, recently, phage display technology is emerging as a powerful selection technique for obtaining functional peptides on a large scale and at a low cost. In particular, these peptides have demonstrated advantages such as high biocompatibility; the ability to be immobilized directly on chondro- and osteoinductive nanomaterials; and improving the cell attachment, differentiation, development and regeneration of osteochondral tissue. In this context, the aim of the present review was to go through the recent literature underlining the importance of studying novel functional motifs related to growth factor mimetic peptides that could be a useful tool in osteochondral repair strategies. Moreover, the review summarizes the current knowledge of the use of phage display peptides in osteochondral tissue regeneration. |
| first_indexed | 2024-03-09T21:48:18Z |
| format | Article |
| id | doaj.art-b901252bdb334fbcb40813d364efa719 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:48:18Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b901252bdb334fbcb40813d364efa7192023-11-23T20:13:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012313738810.3390/ijms23137388Multipotential Role of Growth Factor Mimetic Peptides for Osteochondral Tissue EngineeringMaria Giovanna Rizzo0Nicoletta Palermo1Ugo D’Amora2Salvatore Oddo3Salvatore Pietro Paolo Guglielmino4Sabrina Conoci5Marta Anna Szychlinska6Giovanna Calabrese7Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres, 31, 98168 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres, 31, 98168 Messina, ItalyInstitute of Polymers, Composites and Biomaterials—National Research Council, Viale J. F. Kennedy 54, Mostra d’Oltremare, Pad. 20, 80125 Naples, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres, 31, 98168 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres, 31, 98168 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres, 31, 98168 Messina, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Via del Vespro, 129, 90127 Palermo, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres, 31, 98168 Messina, ItalyArticular cartilage is characterized by a poor self-healing capacity due to its aneural and avascular nature. Once injured, it undergoes a series of catabolic processes which lead to its progressive degeneration and the onset of a severe chronic disease called osteoarthritis (OA). In OA, important alterations of the morpho-functional organization occur in the cartilage extracellular matrix, involving all the nearby tissues, including the subchondral bone. Osteochondral engineering, based on a perfect combination of cells, biomaterials and biomolecules, is becoming increasingly successful for the regeneration of injured cartilage and underlying subchondral bone tissue. To this end, recently, several peptides have been explored as active molecules and enrichment motifs for the functionalization of biomaterials due to their ability to be easily chemically synthesized, as well as their tunable physico-chemical features, low immunogenicity issues and functional group modeling properties. In addition, they have shown a good aptitude to penetrate into the tissue due to their small size and stability at room temperature. In particular, growth-factor-derived peptides can play multiple functions in bone and cartilage repair, exhibiting chondrogenic/osteogenic differentiation properties. Among the most studied peptides, great attention has been paid to transforming growth factor-β and bone morphogenetic protein mimetic peptides, cell-penetrating peptides, cell-binding peptides, self-assembling peptides and extracellular matrix-derived peptides. Moreover, recently, phage display technology is emerging as a powerful selection technique for obtaining functional peptides on a large scale and at a low cost. In particular, these peptides have demonstrated advantages such as high biocompatibility; the ability to be immobilized directly on chondro- and osteoinductive nanomaterials; and improving the cell attachment, differentiation, development and regeneration of osteochondral tissue. In this context, the aim of the present review was to go through the recent literature underlining the importance of studying novel functional motifs related to growth factor mimetic peptides that could be a useful tool in osteochondral repair strategies. Moreover, the review summarizes the current knowledge of the use of phage display peptides in osteochondral tissue regeneration.https://www.mdpi.com/1422-0067/23/13/7388osteoarthritiscartilagetissue regenerationtissue engineeringbiomimetic peptidesphage-based functional peptides |
| spellingShingle | Maria Giovanna Rizzo Nicoletta Palermo Ugo D’Amora Salvatore Oddo Salvatore Pietro Paolo Guglielmino Sabrina Conoci Marta Anna Szychlinska Giovanna Calabrese Multipotential Role of Growth Factor Mimetic Peptides for Osteochondral Tissue Engineering International Journal of Molecular Sciences osteoarthritis cartilage tissue regeneration tissue engineering biomimetic peptides phage-based functional peptides |
| title | Multipotential Role of Growth Factor Mimetic Peptides for Osteochondral Tissue Engineering |
| title_full | Multipotential Role of Growth Factor Mimetic Peptides for Osteochondral Tissue Engineering |
| title_fullStr | Multipotential Role of Growth Factor Mimetic Peptides for Osteochondral Tissue Engineering |
| title_full_unstemmed | Multipotential Role of Growth Factor Mimetic Peptides for Osteochondral Tissue Engineering |
| title_short | Multipotential Role of Growth Factor Mimetic Peptides for Osteochondral Tissue Engineering |
| title_sort | multipotential role of growth factor mimetic peptides for osteochondral tissue engineering |
| topic | osteoarthritis cartilage tissue regeneration tissue engineering biomimetic peptides phage-based functional peptides |
| url | https://www.mdpi.com/1422-0067/23/13/7388 |
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