Interaction Between Chitosan and Mucin: Fundamentals and Applications
The term chitosan (CS) refers to a family of aminopolysaccharides derived from chitin. Among other properties, CS is nontoxic, mucoadhesive and can be used for load and transport drugs. Given these and other physicochemical and biological properties, CS is an optimal biopolymer for the development o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-04-01
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| Series: | Biomimetics |
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| Online Access: | https://www.mdpi.com/2313-7673/4/2/32 |
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| author | Mar Collado-González Yadira González Espinosa Francisco M. Goycoolea |
| author_facet | Mar Collado-González Yadira González Espinosa Francisco M. Goycoolea |
| author_sort | Mar Collado-González |
| collection | DOAJ |
| description | The term chitosan (CS) refers to a family of aminopolysaccharides derived from chitin. Among other properties, CS is nontoxic, mucoadhesive and can be used for load and transport drugs. Given these and other physicochemical and biological properties, CS is an optimal biopolymer for the development of transmucosal drug delivery systems, as well as for the treatment of pathologies related to mucosal dysfunctions. Mucins are glycoprotein macromolecules that are the major components of mucus overlaying epithelia. CS interacts with mucin and adsorbs on and changes the rheology of mucus. However, CS and mucins denote families of polymers/macromolecules with highly variable chemical structure, properties, and behavior. To date, their interactions at the molecular level have not been completely unraveled. Also, the properties of complexes composed of CS and mucin vary as a function of the sources and preparation of the polymers. As a consequence, the mucoadhesion and drug delivery properties of such complexes vary as well. The breadth of this review is on the molecular interactions between CS and mucin. In particular, in vitro and ex vivo characterization methods to investigate both the interactions at play during the formation of CS-mucin complexes, and the advances on the use of CS for transmucosal drug delivery are addressed. |
| first_indexed | 2024-04-11T23:52:14Z |
| format | Article |
| id | doaj.art-b9015a577f854306b324e1cfc7ff62a3 |
| institution | Directory Open Access Journal |
| issn | 2313-7673 |
| language | English |
| last_indexed | 2024-04-11T23:52:14Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomimetics |
| spelling | doaj.art-b9015a577f854306b324e1cfc7ff62a32022-12-22T03:56:27ZengMDPI AGBiomimetics2313-76732019-04-01423210.3390/biomimetics4020032biomimetics4020032Interaction Between Chitosan and Mucin: Fundamentals and ApplicationsMar Collado-González0Yadira González Espinosa1Francisco M. Goycoolea2School of Food Science & Nutrition, University of Leeds, Leeds LS2 9JT, UKSchool of Food Science & Nutrition, University of Leeds, Leeds LS2 9JT, UKSchool of Food Science & Nutrition, University of Leeds, Leeds LS2 9JT, UKThe term chitosan (CS) refers to a family of aminopolysaccharides derived from chitin. Among other properties, CS is nontoxic, mucoadhesive and can be used for load and transport drugs. Given these and other physicochemical and biological properties, CS is an optimal biopolymer for the development of transmucosal drug delivery systems, as well as for the treatment of pathologies related to mucosal dysfunctions. Mucins are glycoprotein macromolecules that are the major components of mucus overlaying epithelia. CS interacts with mucin and adsorbs on and changes the rheology of mucus. However, CS and mucins denote families of polymers/macromolecules with highly variable chemical structure, properties, and behavior. To date, their interactions at the molecular level have not been completely unraveled. Also, the properties of complexes composed of CS and mucin vary as a function of the sources and preparation of the polymers. As a consequence, the mucoadhesion and drug delivery properties of such complexes vary as well. The breadth of this review is on the molecular interactions between CS and mucin. In particular, in vitro and ex vivo characterization methods to investigate both the interactions at play during the formation of CS-mucin complexes, and the advances on the use of CS for transmucosal drug delivery are addressed.https://www.mdpi.com/2313-7673/4/2/32chitosanmucininteractionscomplexesmucoadhesionmucosa |
| spellingShingle | Mar Collado-González Yadira González Espinosa Francisco M. Goycoolea Interaction Between Chitosan and Mucin: Fundamentals and Applications Biomimetics chitosan mucin interactions complexes mucoadhesion mucosa |
| title | Interaction Between Chitosan and Mucin: Fundamentals and Applications |
| title_full | Interaction Between Chitosan and Mucin: Fundamentals and Applications |
| title_fullStr | Interaction Between Chitosan and Mucin: Fundamentals and Applications |
| title_full_unstemmed | Interaction Between Chitosan and Mucin: Fundamentals and Applications |
| title_short | Interaction Between Chitosan and Mucin: Fundamentals and Applications |
| title_sort | interaction between chitosan and mucin fundamentals and applications |
| topic | chitosan mucin interactions complexes mucoadhesion mucosa |
| url | https://www.mdpi.com/2313-7673/4/2/32 |
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