Instability of spiral and scroll waves in the presence of a gradient in the fibroblast density: the effects of fibroblast–myocyte coupling
Fibroblast–myocyte coupling can modulate electrical-wave dynamics in cardiac tissue. In diseased hearts, the distribution of fibroblasts is heterogeneous, so there can be gradients in the fibroblast density (henceforth we call this GFD) especially from highly injured regions, like infarcted or ische...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2016-01-01
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| Series: | New Journal of Physics |
| Subjects: | |
| Online Access: | https://doi.org/10.1088/1367-2630/18/12/123014 |
| _version_ | 1797750849493008384 |
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| author | Soling Zimik Rahul Pandit |
| author_facet | Soling Zimik Rahul Pandit |
| author_sort | Soling Zimik |
| collection | DOAJ |
| description | Fibroblast–myocyte coupling can modulate electrical-wave dynamics in cardiac tissue. In diseased hearts, the distribution of fibroblasts is heterogeneous, so there can be gradients in the fibroblast density (henceforth we call this GFD) especially from highly injured regions, like infarcted or ischemic zones, to less-wounded regions of the tissue. Fibrotic hearts are known to be prone to arrhythmias, so it is important to understand the effects of GFD in the formation and sustenance of arrhythmic re-entrant waves, like spiral or scroll waves. Therefore, we investigate the effects of GFD on the stability of spiral and scroll waves of electrical activation in a state-of-the-art mathematical model for cardiac tissue in which we also include fibroblasts. By introducing GFD in controlled ways, we show that spiral and scroll waves can be unstable in the presence of GFDs because of regions with varying spiral- or scroll-wave frequency ω , induced by the GFD. We examine the effects of the resting membrane potential of the fibroblast and the number of fibroblasts attached to the myocytes on the stability of these waves. Finally, we show that the presence of GFDs can lead to the formation of spiral waves at high-frequency pacing. |
| first_indexed | 2024-03-12T16:39:49Z |
| format | Article |
| id | doaj.art-b9029e1302b943779635ef26b297dc95 |
| institution | Directory Open Access Journal |
| issn | 1367-2630 |
| language | English |
| last_indexed | 2024-03-12T16:39:49Z |
| publishDate | 2016-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | New Journal of Physics |
| spelling | doaj.art-b9029e1302b943779635ef26b297dc952023-08-08T14:36:32ZengIOP PublishingNew Journal of Physics1367-26302016-01-01181212301410.1088/1367-2630/18/12/123014Instability of spiral and scroll waves in the presence of a gradient in the fibroblast density: the effects of fibroblast–myocyte couplingSoling Zimik0Rahul Pandit1Centre for Condensed Matter Theory, Department of Physics, Indian Institute of Science , Bangalore, 560012, IndiaCentre for Condensed Matter Theory, Department of Physics, Indian Institute of Science , Bangalore, 560012, IndiaFibroblast–myocyte coupling can modulate electrical-wave dynamics in cardiac tissue. In diseased hearts, the distribution of fibroblasts is heterogeneous, so there can be gradients in the fibroblast density (henceforth we call this GFD) especially from highly injured regions, like infarcted or ischemic zones, to less-wounded regions of the tissue. Fibrotic hearts are known to be prone to arrhythmias, so it is important to understand the effects of GFD in the formation and sustenance of arrhythmic re-entrant waves, like spiral or scroll waves. Therefore, we investigate the effects of GFD on the stability of spiral and scroll waves of electrical activation in a state-of-the-art mathematical model for cardiac tissue in which we also include fibroblasts. By introducing GFD in controlled ways, we show that spiral and scroll waves can be unstable in the presence of GFDs because of regions with varying spiral- or scroll-wave frequency ω , induced by the GFD. We examine the effects of the resting membrane potential of the fibroblast and the number of fibroblasts attached to the myocytes on the stability of these waves. Finally, we show that the presence of GFDs can lead to the formation of spiral waves at high-frequency pacing.https://doi.org/10.1088/1367-2630/18/12/123014fibroblastsspiral wavesscroll waves |
| spellingShingle | Soling Zimik Rahul Pandit Instability of spiral and scroll waves in the presence of a gradient in the fibroblast density: the effects of fibroblast–myocyte coupling New Journal of Physics fibroblasts spiral waves scroll waves |
| title | Instability of spiral and scroll waves in the presence of a gradient in the fibroblast density: the effects of fibroblast–myocyte coupling |
| title_full | Instability of spiral and scroll waves in the presence of a gradient in the fibroblast density: the effects of fibroblast–myocyte coupling |
| title_fullStr | Instability of spiral and scroll waves in the presence of a gradient in the fibroblast density: the effects of fibroblast–myocyte coupling |
| title_full_unstemmed | Instability of spiral and scroll waves in the presence of a gradient in the fibroblast density: the effects of fibroblast–myocyte coupling |
| title_short | Instability of spiral and scroll waves in the presence of a gradient in the fibroblast density: the effects of fibroblast–myocyte coupling |
| title_sort | instability of spiral and scroll waves in the presence of a gradient in the fibroblast density the effects of fibroblast myocyte coupling |
| topic | fibroblasts spiral waves scroll waves |
| url | https://doi.org/10.1088/1367-2630/18/12/123014 |
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