Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease
Abstract Background Disease-related stress can trigger the occurrence of herpes zoster (HZ). Fatty liver disease (FLD) can have adverse effects on the human body and may induce stress in affected individuals. In this study, we investigated whether FLD is associated with an elevated risk of HZ. Metho...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01524-6 |
| _version_ | 1827604053875490816 |
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| author | Cheng-Wei Yu Chia-Hung Chen Yung-Chi Cheng Wen-Che Hsieh Tzu-Ju Hsu Fuu-Jen Tsai Chao-Yu Hsu |
| author_facet | Cheng-Wei Yu Chia-Hung Chen Yung-Chi Cheng Wen-Che Hsieh Tzu-Ju Hsu Fuu-Jen Tsai Chao-Yu Hsu |
| author_sort | Cheng-Wei Yu |
| collection | DOAJ |
| description | Abstract Background Disease-related stress can trigger the occurrence of herpes zoster (HZ). Fatty liver disease (FLD) can have adverse effects on the human body and may induce stress in affected individuals. In this study, we investigated whether FLD is associated with an elevated risk of HZ. Methods For this study, we utilized data from the National Health Insurance Research Database, patients with FLD from 2000 to 2017 were observed (follow-up until 2018). Patients were considered to have FLD if they had at least two outpatient visits or at least one admission record with a diagnostic code of FLD. Patients with FLD were matched 1:1 by age, sex, comorbidities, and index year with control patients. Additionally, the FLD was further categorized into non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD) groups. Multivariable Cox proportional hazards model was used to calculate the incidence rate and adjusted hazard ratio (aHR) of HZ for FLD and AFLD and for various age groups, sex and comorbidities. Cumulative incidence curve for HZ was plotted through the Kaplan–Meier method, and p-value was calculated using the log-rank test. Results After 1:1 propensity-score matching, each cohort comprised 62,418 patients. The FLD cohort was further divided into NAFLD and AFLD groups, which respectively comprised 55,709 and 6709 patients. The FLD cohort had a risk of HZ significantly higher than that of the control cohort (aHR = 1.06; p < 0.001). Additionally, the NAFLD group exhibited a significantly higher risk of HZ than did the AFLD group (aHR = 1.22; p < 0.001). Among patients without any comorbidities, those with FLD had a higher risk of HZ than did those without FLD (aHR = 1.14; p < 0.001). Conclusion Patients with FLD are at an increased risk of HZ development. Additionally, NAFLD is associated with a higher risk of HZ than AFLD. Therefore, patients with NAFLD should be informed of their increased risk of HZ. |
| first_indexed | 2024-03-09T05:52:33Z |
| format | Article |
| id | doaj.art-b90330cd87244f14b7ca4fdebf009279 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-09T05:52:33Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-b90330cd87244f14b7ca4fdebf0092792023-12-03T12:16:16ZengBMCEuropean Journal of Medical Research2047-783X2023-12-0128111010.1186/s40001-023-01524-6Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver diseaseCheng-Wei Yu0Chia-Hung Chen1Yung-Chi Cheng2Wen-Che Hsieh3Tzu-Ju Hsu4Fuu-Jen Tsai5Chao-Yu Hsu6Department of Nutrition, Ditmanson Medical Foundation, Chia-Yi Christian HospitalDepartment of Medical Education, Ditmanson Medical Foundation, Chia-Yi Christian HospitalDepartment of Medical Education, Ditmanson Medical Foundation, Chia-Yi Christian HospitalDepartment of Chinese Medicine, Ditmanson Medical Foundation, Chia-Yi Christian HospitalManagement Office for Health Data, Clinical Trial Research Center, China Medical University HospitalSchool of Chinese Medicine, College of Chinese Medicine, China Medical UniversityDepartment of Medical Education, Ditmanson Medical Foundation, Chia-Yi Christian HospitalAbstract Background Disease-related stress can trigger the occurrence of herpes zoster (HZ). Fatty liver disease (FLD) can have adverse effects on the human body and may induce stress in affected individuals. In this study, we investigated whether FLD is associated with an elevated risk of HZ. Methods For this study, we utilized data from the National Health Insurance Research Database, patients with FLD from 2000 to 2017 were observed (follow-up until 2018). Patients were considered to have FLD if they had at least two outpatient visits or at least one admission record with a diagnostic code of FLD. Patients with FLD were matched 1:1 by age, sex, comorbidities, and index year with control patients. Additionally, the FLD was further categorized into non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD) groups. Multivariable Cox proportional hazards model was used to calculate the incidence rate and adjusted hazard ratio (aHR) of HZ for FLD and AFLD and for various age groups, sex and comorbidities. Cumulative incidence curve for HZ was plotted through the Kaplan–Meier method, and p-value was calculated using the log-rank test. Results After 1:1 propensity-score matching, each cohort comprised 62,418 patients. The FLD cohort was further divided into NAFLD and AFLD groups, which respectively comprised 55,709 and 6709 patients. The FLD cohort had a risk of HZ significantly higher than that of the control cohort (aHR = 1.06; p < 0.001). Additionally, the NAFLD group exhibited a significantly higher risk of HZ than did the AFLD group (aHR = 1.22; p < 0.001). Among patients without any comorbidities, those with FLD had a higher risk of HZ than did those without FLD (aHR = 1.14; p < 0.001). Conclusion Patients with FLD are at an increased risk of HZ development. Additionally, NAFLD is associated with a higher risk of HZ than AFLD. Therefore, patients with NAFLD should be informed of their increased risk of HZ.https://doi.org/10.1186/s40001-023-01524-6Non-alcoholic fatty liver diseaseAlcoholic fatty liver diseaseHerpes zoster |
| spellingShingle | Cheng-Wei Yu Chia-Hung Chen Yung-Chi Cheng Wen-Che Hsieh Tzu-Ju Hsu Fuu-Jen Tsai Chao-Yu Hsu Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease European Journal of Medical Research Non-alcoholic fatty liver disease Alcoholic fatty liver disease Herpes zoster |
| title | Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease |
| title_full | Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease |
| title_fullStr | Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease |
| title_full_unstemmed | Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease |
| title_short | Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease |
| title_sort | non alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease |
| topic | Non-alcoholic fatty liver disease Alcoholic fatty liver disease Herpes zoster |
| url | https://doi.org/10.1186/s40001-023-01524-6 |
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