Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment
We report the first case of microabscesses detected by polymerase chain reaction (PCR) amplification of nucleic acid from ultrasound-guided aspirated fluid in a three-year old boy with acute lymphoblastic leukemia and febrile neutropenia during induction chemotherapy. Fever persisted despite effecti...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-04-01
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| Series: | International Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971219300669 |
| _version_ | 1818266053494439936 |
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| author | Jaime S. Rosa Duque Kelvin K.W. To Alan K.S. Chiang Godfrey C.F. Chan Rosana W.S. Poon Kwok-Yung Yuen Shau-Yin Ha Daniel K.L. Cheuk |
| author_facet | Jaime S. Rosa Duque Kelvin K.W. To Alan K.S. Chiang Godfrey C.F. Chan Rosana W.S. Poon Kwok-Yung Yuen Shau-Yin Ha Daniel K.L. Cheuk |
| author_sort | Jaime S. Rosa Duque |
| collection | DOAJ |
| description | We report the first case of microabscesses detected by polymerase chain reaction (PCR) amplification of nucleic acid from ultrasound-guided aspirated fluid in a three-year old boy with acute lymphoblastic leukemia and febrile neutropenia during induction chemotherapy. Fever persisted despite effective antifungal treatment. The addition of corticosteroid therapy successfully controlled the suspected immune reconstitution inflammatory syndrome (IRIS). This case highlights the utility of PCR and adjunctive corticosteroid in the approach of Candida tropicalis renal microabscesses in leukemic patients undergoing chemotherapy. Keywords: Renal abscess, Candida, Leukemia, Nucleic acid amplification, Polymerase chain reaction |
| first_indexed | 2024-12-12T20:00:35Z |
| format | Article |
| id | doaj.art-b904990d3c894deab5665233ff89a070 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-12T20:00:35Z |
| publishDate | 2019-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-b904990d3c894deab5665233ff89a0702022-12-22T00:13:46ZengElsevierInternational Journal of Infectious Diseases1201-97122019-04-0181110113Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatmentJaime S. Rosa Duque0Kelvin K.W. To1Alan K.S. Chiang2Godfrey C.F. Chan3Rosana W.S. Poon4Kwok-Yung Yuen5Shau-Yin Ha6Daniel K.L. Cheuk7Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Corresponding author at: Department of Paediatrics and Adolescent Medicine, Room 115, New Clinical Bldg, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong.Department of Microbiology, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong KongDepartment of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong KongDepartment of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong KongDepartment of Microbiology, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong KongDepartment of Microbiology, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong KongDepartment of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong KongDepartment of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong KongWe report the first case of microabscesses detected by polymerase chain reaction (PCR) amplification of nucleic acid from ultrasound-guided aspirated fluid in a three-year old boy with acute lymphoblastic leukemia and febrile neutropenia during induction chemotherapy. Fever persisted despite effective antifungal treatment. The addition of corticosteroid therapy successfully controlled the suspected immune reconstitution inflammatory syndrome (IRIS). This case highlights the utility of PCR and adjunctive corticosteroid in the approach of Candida tropicalis renal microabscesses in leukemic patients undergoing chemotherapy. Keywords: Renal abscess, Candida, Leukemia, Nucleic acid amplification, Polymerase chain reactionhttp://www.sciencedirect.com/science/article/pii/S1201971219300669 |
| spellingShingle | Jaime S. Rosa Duque Kelvin K.W. To Alan K.S. Chiang Godfrey C.F. Chan Rosana W.S. Poon Kwok-Yung Yuen Shau-Yin Ha Daniel K.L. Cheuk Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment International Journal of Infectious Diseases |
| title | Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment |
| title_full | Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment |
| title_fullStr | Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment |
| title_full_unstemmed | Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment |
| title_short | Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment |
| title_sort | candida tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment |
| url | http://www.sciencedirect.com/science/article/pii/S1201971219300669 |
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