Mitochondrial Lipids: From Membrane Organization to Apoptotic Facilitation
Mitochondria are the most complex intracellular organelles, their function combining energy production for survival and apoptosis facilitation for death. Such a multivariate physiology is structurally and functionally reflected upon their membrane configuration and lipid composition. Mitochondrial d...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/7/3738 |
| _version_ | 1797439020101271552 |
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| author | Aikaterini Poulaki Stavroula Giannouli |
| author_facet | Aikaterini Poulaki Stavroula Giannouli |
| author_sort | Aikaterini Poulaki |
| collection | DOAJ |
| description | Mitochondria are the most complex intracellular organelles, their function combining energy production for survival and apoptosis facilitation for death. Such a multivariate physiology is structurally and functionally reflected upon their membrane configuration and lipid composition. Mitochondrial double membrane lipids, with cardiolipin as the protagonist, show an impressive level of complexity that is mandatory for maintenance of mitochondrial health and protection from apoptosis. Given that lipidomics is an emerging field in cancer research and that mitochondria are the organelles with the most important role in malignant maintenance knowledge of the mitochondrial membrane, lipid physiology in health is mandatory. In this review, we will thus describe the delicate nature of the healthy mitochondrial double membrane and its role in apoptosis. Emphasis will be given on mitochondrial membrane lipids and the changes that they undergo during apoptosis induction and progression. |
| first_indexed | 2024-03-09T11:46:48Z |
| format | Article |
| id | doaj.art-b90531e7461b4c39ae04e27d16ee4968 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T11:46:48Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b90531e7461b4c39ae04e27d16ee49682023-11-30T23:21:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01237373810.3390/ijms23073738Mitochondrial Lipids: From Membrane Organization to Apoptotic FacilitationAikaterini Poulaki0Stavroula Giannouli1Hematology Unit, Second Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, GreeceHematology Unit, Second Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, GreeceMitochondria are the most complex intracellular organelles, their function combining energy production for survival and apoptosis facilitation for death. Such a multivariate physiology is structurally and functionally reflected upon their membrane configuration and lipid composition. Mitochondrial double membrane lipids, with cardiolipin as the protagonist, show an impressive level of complexity that is mandatory for maintenance of mitochondrial health and protection from apoptosis. Given that lipidomics is an emerging field in cancer research and that mitochondria are the organelles with the most important role in malignant maintenance knowledge of the mitochondrial membrane, lipid physiology in health is mandatory. In this review, we will thus describe the delicate nature of the healthy mitochondrial double membrane and its role in apoptosis. Emphasis will be given on mitochondrial membrane lipids and the changes that they undergo during apoptosis induction and progression.https://www.mdpi.com/1422-0067/23/7/3738apoptosismitochondriamitochondrial lipidscardiolipindouble membranecytochrome C |
| spellingShingle | Aikaterini Poulaki Stavroula Giannouli Mitochondrial Lipids: From Membrane Organization to Apoptotic Facilitation International Journal of Molecular Sciences apoptosis mitochondria mitochondrial lipids cardiolipin double membrane cytochrome C |
| title | Mitochondrial Lipids: From Membrane Organization to Apoptotic Facilitation |
| title_full | Mitochondrial Lipids: From Membrane Organization to Apoptotic Facilitation |
| title_fullStr | Mitochondrial Lipids: From Membrane Organization to Apoptotic Facilitation |
| title_full_unstemmed | Mitochondrial Lipids: From Membrane Organization to Apoptotic Facilitation |
| title_short | Mitochondrial Lipids: From Membrane Organization to Apoptotic Facilitation |
| title_sort | mitochondrial lipids from membrane organization to apoptotic facilitation |
| topic | apoptosis mitochondria mitochondrial lipids cardiolipin double membrane cytochrome C |
| url | https://www.mdpi.com/1422-0067/23/7/3738 |
| work_keys_str_mv | AT aikaterinipoulaki mitochondriallipidsfrommembraneorganizationtoapoptoticfacilitation AT stavroulagiannouli mitochondriallipidsfrommembraneorganizationtoapoptoticfacilitation |