Gene Expression Analysis of the Bone Marrow Microenvironment Reveals Distinct Immunotypes in Smoldering Multiple Myeloma Associated to Progression to Symptomatic Disease

Gene Expression Analysis of the Bone Marrow Microenvironment Reveals Distinct Immunotypes in Smoldering Multiple Myeloma Associated to Progression to Symptomatic Disease

BackgroundWe previously reported algorithms based on clinical parameters and plasma cell characteristics to identify patients with smoldering multiple myeloma (SMM) with higher risk of progressing who could benefit from early treatment. In this work, we analyzed differences in the immune bone marrow...

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Bibliographic Details
Main Authors: Ignacio Isola, Fara Brasó-Maristany, David F. Moreno, Mari-Pau Mena, Aina Oliver-Calders, Laia Paré, Luis Gerardo Rodríguez-Lobato, Beatriz Martin-Antonio, María Teresa Cibeira, Joan Bladé, Laura Rosiñol, Aleix Prat, Ester Lozano, Carlos Fernández de Larrea
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
smoldering multiple myeloma
immunotherapy
immune checkpoints
TIGIT
pronostic factors
bone marrow microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.792609/full

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