Cerebral Venous Outflow Implications in Idiopathic Intracranial Hypertension—From Physiopathology to Treatment
In this review, we provide an update on the pathogenesis, diagnosis, and management of adults with idiopathic intracranial hypertension (IIH) and implications of the cerebral venous system, highlighting the progress made during the past decade with regard to mechanisms of the venous outflow pathway...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/6/854 |
| _version_ | 1797485238534799360 |
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| author | Sorin Tuță |
| author_facet | Sorin Tuță |
| author_sort | Sorin Tuță |
| collection | DOAJ |
| description | In this review, we provide an update on the pathogenesis, diagnosis, and management of adults with idiopathic intracranial hypertension (IIH) and implications of the cerebral venous system, highlighting the progress made during the past decade with regard to mechanisms of the venous outflow pathway and its connection with the cerebral glymphatic and lymphatic network in genesis of IIH. Early diagnosis and treatment are crucial for favorable visual outcomes and to avoid vision loss, but there is also a risk of overdiagnosis and misdiagnosis in many patients with IIH. We also present details about treatment of intracranial hypertension, which is possible in most cases with a combination of weight loss and drug treatments, but also in selected cases with surgical interventions such as optic nerve sheath fenestration, cerebral spinal fluid (CSF) diversion, or dural venous sinus stenting for some patients with cerebral venous sinus stenosis, after careful analysis of mechanisms of intracranial hypertension, patient clinical profile, and method risks. |
| first_indexed | 2024-03-09T23:15:55Z |
| format | Article |
| id | doaj.art-b90811357e4c4a07af3370a78056b242 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T23:15:55Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-b90811357e4c4a07af3370a78056b2422023-11-23T17:36:35ZengMDPI AGLife2075-17292022-06-0112685410.3390/life12060854Cerebral Venous Outflow Implications in Idiopathic Intracranial Hypertension—From Physiopathology to TreatmentSorin Tuță0Department of Neurology, “Carol Davila” University of Medicine and Pharmacy, 050471 Bucharest, RomaniaIn this review, we provide an update on the pathogenesis, diagnosis, and management of adults with idiopathic intracranial hypertension (IIH) and implications of the cerebral venous system, highlighting the progress made during the past decade with regard to mechanisms of the venous outflow pathway and its connection with the cerebral glymphatic and lymphatic network in genesis of IIH. Early diagnosis and treatment are crucial for favorable visual outcomes and to avoid vision loss, but there is also a risk of overdiagnosis and misdiagnosis in many patients with IIH. We also present details about treatment of intracranial hypertension, which is possible in most cases with a combination of weight loss and drug treatments, but also in selected cases with surgical interventions such as optic nerve sheath fenestration, cerebral spinal fluid (CSF) diversion, or dural venous sinus stenting for some patients with cerebral venous sinus stenosis, after careful analysis of mechanisms of intracranial hypertension, patient clinical profile, and method risks.https://www.mdpi.com/2075-1729/12/6/854idiopathic intracranial hypertensionpseudotumor cerebricerebral venous sinus stenosismagnetic resonance venographycerebral venous sinus stentingoptical nerve sheath fenestration |
| spellingShingle | Sorin Tuță Cerebral Venous Outflow Implications in Idiopathic Intracranial Hypertension—From Physiopathology to Treatment Life idiopathic intracranial hypertension pseudotumor cerebri cerebral venous sinus stenosis magnetic resonance venography cerebral venous sinus stenting optical nerve sheath fenestration |
| title | Cerebral Venous Outflow Implications in Idiopathic Intracranial Hypertension—From Physiopathology to Treatment |
| title_full | Cerebral Venous Outflow Implications in Idiopathic Intracranial Hypertension—From Physiopathology to Treatment |
| title_fullStr | Cerebral Venous Outflow Implications in Idiopathic Intracranial Hypertension—From Physiopathology to Treatment |
| title_full_unstemmed | Cerebral Venous Outflow Implications in Idiopathic Intracranial Hypertension—From Physiopathology to Treatment |
| title_short | Cerebral Venous Outflow Implications in Idiopathic Intracranial Hypertension—From Physiopathology to Treatment |
| title_sort | cerebral venous outflow implications in idiopathic intracranial hypertension from physiopathology to treatment |
| topic | idiopathic intracranial hypertension pseudotumor cerebri cerebral venous sinus stenosis magnetic resonance venography cerebral venous sinus stenting optical nerve sheath fenestration |
| url | https://www.mdpi.com/2075-1729/12/6/854 |
| work_keys_str_mv | AT sorintuta cerebralvenousoutflowimplicationsinidiopathicintracranialhypertensionfromphysiopathologytotreatment |