Association of menopausal status with COVID-19 outcomes: a propensity score matching analysis
Abstract Background Despite the growing number of studies on the coronavirus disease-19 (COVID-19), little is known about the association of menopausal status with COVID-19 outcomes. Materials and methods In this retrospective study, we included 336 COVID-19 inpatients between February 15, 2020 and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-01-01
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| Series: | Biology of Sex Differences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13293-021-00363-6 |
| _version_ | 1818916334530985984 |
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| author | Xing-Wang Wang Hao Hu Zhi-Yong Xu Gong-Kai Zhang Qing-Hua Yu Hui-Lan Yang Ji-Hua Zheng |
| author_facet | Xing-Wang Wang Hao Hu Zhi-Yong Xu Gong-Kai Zhang Qing-Hua Yu Hui-Lan Yang Ji-Hua Zheng |
| author_sort | Xing-Wang Wang |
| collection | DOAJ |
| description | Abstract Background Despite the growing number of studies on the coronavirus disease-19 (COVID-19), little is known about the association of menopausal status with COVID-19 outcomes. Materials and methods In this retrospective study, we included 336 COVID-19 inpatients between February 15, 2020 and April 30, 2020 at the Taikang Tongji Hospital (Wuhan), China. Electronic medical records including patient demographics, laboratory results, and chest computed tomography (CT) images were reviewed. Results In total, 300 patients with complete clinical outcomes were included for analysis. The mean age was 65.3 years, and most patients were women (n = 167, 55.7%). Over 50% of patients presented with comorbidities, with hypertension (63.5%) being the most common comorbidity. After propensity score matching, results showed that men had significantly higher odds than premenopausal women for developing severe disease type (23.7% vs. 0%, OR 17.12, 95% CI 1.00–293.60; p = 0.003) and bilateral lung infiltration (86.1% vs. 64.7%, OR 3.39, 95% CI 1.08–10.64; p = 0.04), but not for mortality (2.0% vs. 0%, OR 0.88, 95% CI 0.04–19.12, p = 1.00). However, non-significant difference was observed among men and postmenopausal women in the percentage of severe disease type (32.7% vs. 41.7%, OR 0.68, 95% CI 0.37–1.24, p = 0.21), bilateral lung infiltration (86.1% vs. 91.7%, OR 0.56, 95% CI 0.22–1.47, p = 0.24), and mortality (2.0% vs. 6.0%, OR 0.32, 95% CI 0.06–1.69, p = 0.25). Conclusions Men had higher disease severity than premenopausal women, while the differences disappeared between postmenopausal women and men. These findings support aggressive treatment for the poor prognosis of postmenopausal women in clinical practice. |
| first_indexed | 2024-12-20T00:16:31Z |
| format | Article |
| id | doaj.art-b90938fcfbea4da7a01a022b60b10de1 |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-12-20T00:16:31Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-b90938fcfbea4da7a01a022b60b10de12022-12-21T20:00:19ZengBMCBiology of Sex Differences2042-64102021-01-011211810.1186/s13293-021-00363-6Association of menopausal status with COVID-19 outcomes: a propensity score matching analysisXing-Wang Wang0Hao Hu1Zhi-Yong Xu2Gong-Kai Zhang3Qing-Hua Yu4Hui-Lan Yang5Ji-Hua Zheng6Department of Dermatology, General Hospital of Southern Theater CommandDepartment of Radiation Therapy, General Hospital of Southern Theater CommandDepartment of Radiation Therapy, General Hospital of Southern Theater CommandDepartment of Dermatology, General Hospital of Southern Theater CommandDepartment of Emergency, General Hospital of Southern Theater CommandDepartment of Dermatology, General Hospital of Southern Theater CommandDepartment of Radiation Therapy, General Hospital of Southern Theater CommandAbstract Background Despite the growing number of studies on the coronavirus disease-19 (COVID-19), little is known about the association of menopausal status with COVID-19 outcomes. Materials and methods In this retrospective study, we included 336 COVID-19 inpatients between February 15, 2020 and April 30, 2020 at the Taikang Tongji Hospital (Wuhan), China. Electronic medical records including patient demographics, laboratory results, and chest computed tomography (CT) images were reviewed. Results In total, 300 patients with complete clinical outcomes were included for analysis. The mean age was 65.3 years, and most patients were women (n = 167, 55.7%). Over 50% of patients presented with comorbidities, with hypertension (63.5%) being the most common comorbidity. After propensity score matching, results showed that men had significantly higher odds than premenopausal women for developing severe disease type (23.7% vs. 0%, OR 17.12, 95% CI 1.00–293.60; p = 0.003) and bilateral lung infiltration (86.1% vs. 64.7%, OR 3.39, 95% CI 1.08–10.64; p = 0.04), but not for mortality (2.0% vs. 0%, OR 0.88, 95% CI 0.04–19.12, p = 1.00). However, non-significant difference was observed among men and postmenopausal women in the percentage of severe disease type (32.7% vs. 41.7%, OR 0.68, 95% CI 0.37–1.24, p = 0.21), bilateral lung infiltration (86.1% vs. 91.7%, OR 0.56, 95% CI 0.22–1.47, p = 0.24), and mortality (2.0% vs. 6.0%, OR 0.32, 95% CI 0.06–1.69, p = 0.25). Conclusions Men had higher disease severity than premenopausal women, while the differences disappeared between postmenopausal women and men. These findings support aggressive treatment for the poor prognosis of postmenopausal women in clinical practice.https://doi.org/10.1186/s13293-021-00363-6COVID-19Menopause statusMortalityDisease severityPropensity score matching |
| spellingShingle | Xing-Wang Wang Hao Hu Zhi-Yong Xu Gong-Kai Zhang Qing-Hua Yu Hui-Lan Yang Ji-Hua Zheng Association of menopausal status with COVID-19 outcomes: a propensity score matching analysis Biology of Sex Differences COVID-19 Menopause status Mortality Disease severity Propensity score matching |
| title | Association of menopausal status with COVID-19 outcomes: a propensity score matching analysis |
| title_full | Association of menopausal status with COVID-19 outcomes: a propensity score matching analysis |
| title_fullStr | Association of menopausal status with COVID-19 outcomes: a propensity score matching analysis |
| title_full_unstemmed | Association of menopausal status with COVID-19 outcomes: a propensity score matching analysis |
| title_short | Association of menopausal status with COVID-19 outcomes: a propensity score matching analysis |
| title_sort | association of menopausal status with covid 19 outcomes a propensity score matching analysis |
| topic | COVID-19 Menopause status Mortality Disease severity Propensity score matching |
| url | https://doi.org/10.1186/s13293-021-00363-6 |
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