Epigenetic Marks at the Ribosomal DNA Promoter in Skeletal Muscle Are Negatively Associated With Degree of Impairment in Cerebral Palsy

Epigenetic Marks at the Ribosomal DNA Promoter in Skeletal Muscle Are Negatively Associated With Degree of Impairment in Cerebral Palsy

Introduction: Cerebral palsy (CP) is the most common motor impairment in children. Skeletal muscles in individuals with CP are typically weak, thin, and stiff. Whether epigenetic changes at the ribosomal DNA (rDNA) promoter are involved in this dysregulation remains unknown.Methods: Skeletal muscle...

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Bibliographic Details
Main Authors: Ferdinand von Walden, Rodrigo Fernandez-Gonzalo, Jessica Pingel, John McCarthy, Per Stål, Eva Pontén
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pediatrics
Subjects:
cerebral palsy
skeletal muscle
epigenetics
ribosome biogenesis
DNA methylation
Online Access:https://www.frontiersin.org/article/10.3389/fped.2020.00236/full

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