Association of CYP2A6*4 with susceptibility of lung cancer: a meta-analysis.
To assess the association between the variant of Cytochrome P450 2A6 whole gene deletion (CYP2A6*4) polymorphism and risk of lung cancer.Two investigators independently searched the PubMed, Elsevier, EMBASE, Web of Science, Wiley Online Library and Chinese National Knowledge Infrastructure (CNKI). P...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3622000?pdf=render |
| _version_ | 1818428260040572928 |
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| author | Lishan Wang Weidong Zang Jiang Liu Dongli Xie Weidong Ji Yaosheng Pan Zhiqiang Li Jiawei Shen Yongyong Shi |
| author_facet | Lishan Wang Weidong Zang Jiang Liu Dongli Xie Weidong Ji Yaosheng Pan Zhiqiang Li Jiawei Shen Yongyong Shi |
| author_sort | Lishan Wang |
| collection | DOAJ |
| description | To assess the association between the variant of Cytochrome P450 2A6 whole gene deletion (CYP2A6*4) polymorphism and risk of lung cancer.Two investigators independently searched the PubMed, Elsevier, EMBASE, Web of Science, Wiley Online Library and Chinese National Knowledge Infrastructure (CNKI). Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for CYP2A6*4 and lung cancer were calculated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate.This meta-analysis included seven eligible studies, which included 2524 lung cancer cases and 2258 controls (cancer-free). Overall, CYP2A6*4 was associated with the risk of lung cancer (allele*4 vs. allele non-*4, pooled OR = 0.826, 95% CI = 0.725-0.941, P-value = 0.004). When stratifying for population, significant association was observed in Asian (additive model, pooled OR = 0.794, 95% CI = 0.694-0.909, P-value = 0.001; dominant model, pooled OR = 0.827, 95% CI = 0.709-0.965, P-value = 0.016; recessive model (pooled OR = 0.444, 95% CI = 0.293-0.675, P-value <0.0001). In the overall analysis, a comparably significant decrease in the frequency of *4/*4 genotype was detected between cases and controls in Asian while no *4/*4 genotype was detected in Caucasian in collected data.This meta-analysis suggests that the CYP2A6*4 polymorphism is associated with susceptibility of lung cancer in Asian. The whole gene deletion of CYP2A6 may decrease the risk of lung cancer in Asian samples. |
| first_indexed | 2024-12-14T14:58:47Z |
| format | Article |
| id | doaj.art-b90c71c1d44c4eaea9bc9ee4da8590dd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T14:58:47Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b90c71c1d44c4eaea9bc9ee4da8590dd2022-12-21T22:56:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e5955610.1371/journal.pone.0059556Association of CYP2A6*4 with susceptibility of lung cancer: a meta-analysis.Lishan WangWeidong ZangJiang LiuDongli XieWeidong JiYaosheng PanZhiqiang LiJiawei ShenYongyong ShiTo assess the association between the variant of Cytochrome P450 2A6 whole gene deletion (CYP2A6*4) polymorphism and risk of lung cancer.Two investigators independently searched the PubMed, Elsevier, EMBASE, Web of Science, Wiley Online Library and Chinese National Knowledge Infrastructure (CNKI). Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for CYP2A6*4 and lung cancer were calculated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate.This meta-analysis included seven eligible studies, which included 2524 lung cancer cases and 2258 controls (cancer-free). Overall, CYP2A6*4 was associated with the risk of lung cancer (allele*4 vs. allele non-*4, pooled OR = 0.826, 95% CI = 0.725-0.941, P-value = 0.004). When stratifying for population, significant association was observed in Asian (additive model, pooled OR = 0.794, 95% CI = 0.694-0.909, P-value = 0.001; dominant model, pooled OR = 0.827, 95% CI = 0.709-0.965, P-value = 0.016; recessive model (pooled OR = 0.444, 95% CI = 0.293-0.675, P-value <0.0001). In the overall analysis, a comparably significant decrease in the frequency of *4/*4 genotype was detected between cases and controls in Asian while no *4/*4 genotype was detected in Caucasian in collected data.This meta-analysis suggests that the CYP2A6*4 polymorphism is associated with susceptibility of lung cancer in Asian. The whole gene deletion of CYP2A6 may decrease the risk of lung cancer in Asian samples.http://europepmc.org/articles/PMC3622000?pdf=render |
| spellingShingle | Lishan Wang Weidong Zang Jiang Liu Dongli Xie Weidong Ji Yaosheng Pan Zhiqiang Li Jiawei Shen Yongyong Shi Association of CYP2A6*4 with susceptibility of lung cancer: a meta-analysis. PLoS ONE |
| title | Association of CYP2A6*4 with susceptibility of lung cancer: a meta-analysis. |
| title_full | Association of CYP2A6*4 with susceptibility of lung cancer: a meta-analysis. |
| title_fullStr | Association of CYP2A6*4 with susceptibility of lung cancer: a meta-analysis. |
| title_full_unstemmed | Association of CYP2A6*4 with susceptibility of lung cancer: a meta-analysis. |
| title_short | Association of CYP2A6*4 with susceptibility of lung cancer: a meta-analysis. |
| title_sort | association of cyp2a6 4 with susceptibility of lung cancer a meta analysis |
| url | http://europepmc.org/articles/PMC3622000?pdf=render |
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