Correlation of serum anti-Mullerian hormone with hormonal and environmental parameters in Brazilian climacteric women
Abstract This study aimed to identify the correlation among anti-Mullerian Hormone serum levels and 25-OH-D, obesity, metabolic syndrome (MetS), and sexual hormones in climacteric women classified according to stages of reproductive aging (SRA). A cross-sectional study was conducted with a total of...
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| Format: | Article |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-15429-7 |
| _version_ | 1818517731928965120 |
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| author | Thiago Magalhães Gouvea Laura Alves Cota e Souza Angélica Alves Lima |
| author_facet | Thiago Magalhães Gouvea Laura Alves Cota e Souza Angélica Alves Lima |
| author_sort | Thiago Magalhães Gouvea |
| collection | DOAJ |
| description | Abstract This study aimed to identify the correlation among anti-Mullerian Hormone serum levels and 25-OH-D, obesity, metabolic syndrome (MetS), and sexual hormones in climacteric women classified according to stages of reproductive aging (SRA). A cross-sectional study was conducted with a total of 177 Brazilian climacteric women between 40 and 64 years old. Concentrations of AMH were measured using the Access 2 Immunoassay System. A multiple linear regression analysis was used to identify the relationship among AMH, 25-OH-D, obesity, MetS, sexual hormones, sociodemographic and lifestyle factors. AMH levels decreased with increased age (B = − 0.059; p < 0.001), and reproductive aging (B = − 0.483; p < 0.001). Obesity indicators, lifestyle characters, 25-OH-D levels and MetS were not significantly associated with AMH serum concentration. Negative correlation was found for FSH (B = − 0.009; p < 0.001) and LH (B = − 0.006; p = 0.004); positive correlation for E2 (B = 0.001; p = 0.011), DHEAS (B = 0.003; p < 0.001) and SHBG (B = 0.003; p = 0.005). In the model adjusted for SRA, FSH levels (p < 0.001) and DHEAS (p = 0.014) were associated with AMH. Although, with the adjustment for age, only FSH remained with a significant association (p = 0.001). Of the other analytes, none was associated with AMH, regardless of the model fit. Our findings confirm that serum AMH level decreased with age and FSH levels, but there is no correlation between AMH with obesity, 25-OH-D, MetS or other sexual hormones in Brazilian climacteric women. |
| first_indexed | 2024-12-11T01:00:15Z |
| format | Article |
| id | doaj.art-b90d3ae1fb0e4541835941a5050b06c3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-11T01:00:15Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b90d3ae1fb0e4541835941a5050b06c32022-12-22T01:26:21ZengNature PortfolioScientific Reports2045-23222022-07-011211910.1038/s41598-022-15429-7Correlation of serum anti-Mullerian hormone with hormonal and environmental parameters in Brazilian climacteric womenThiago Magalhães Gouvea0Laura Alves Cota e Souza1Angélica Alves Lima2Programa de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro PretoPrograma de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro PretoPrograma de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro PretoAbstract This study aimed to identify the correlation among anti-Mullerian Hormone serum levels and 25-OH-D, obesity, metabolic syndrome (MetS), and sexual hormones in climacteric women classified according to stages of reproductive aging (SRA). A cross-sectional study was conducted with a total of 177 Brazilian climacteric women between 40 and 64 years old. Concentrations of AMH were measured using the Access 2 Immunoassay System. A multiple linear regression analysis was used to identify the relationship among AMH, 25-OH-D, obesity, MetS, sexual hormones, sociodemographic and lifestyle factors. AMH levels decreased with increased age (B = − 0.059; p < 0.001), and reproductive aging (B = − 0.483; p < 0.001). Obesity indicators, lifestyle characters, 25-OH-D levels and MetS were not significantly associated with AMH serum concentration. Negative correlation was found for FSH (B = − 0.009; p < 0.001) and LH (B = − 0.006; p = 0.004); positive correlation for E2 (B = 0.001; p = 0.011), DHEAS (B = 0.003; p < 0.001) and SHBG (B = 0.003; p = 0.005). In the model adjusted for SRA, FSH levels (p < 0.001) and DHEAS (p = 0.014) were associated with AMH. Although, with the adjustment for age, only FSH remained with a significant association (p = 0.001). Of the other analytes, none was associated with AMH, regardless of the model fit. Our findings confirm that serum AMH level decreased with age and FSH levels, but there is no correlation between AMH with obesity, 25-OH-D, MetS or other sexual hormones in Brazilian climacteric women.https://doi.org/10.1038/s41598-022-15429-7 |
| spellingShingle | Thiago Magalhães Gouvea Laura Alves Cota e Souza Angélica Alves Lima Correlation of serum anti-Mullerian hormone with hormonal and environmental parameters in Brazilian climacteric women Scientific Reports |
| title | Correlation of serum anti-Mullerian hormone with hormonal and environmental parameters in Brazilian climacteric women |
| title_full | Correlation of serum anti-Mullerian hormone with hormonal and environmental parameters in Brazilian climacteric women |
| title_fullStr | Correlation of serum anti-Mullerian hormone with hormonal and environmental parameters in Brazilian climacteric women |
| title_full_unstemmed | Correlation of serum anti-Mullerian hormone with hormonal and environmental parameters in Brazilian climacteric women |
| title_short | Correlation of serum anti-Mullerian hormone with hormonal and environmental parameters in Brazilian climacteric women |
| title_sort | correlation of serum anti mullerian hormone with hormonal and environmental parameters in brazilian climacteric women |
| url | https://doi.org/10.1038/s41598-022-15429-7 |
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