Unusual Clinical Experience in <i>BRAF</i> Exon 15 p.K601E-Mutated Lung Cancer: A Case Report and Brief Review of the Literature
Molecular profiling has revolutionized the treatment of metastatic NSCLC. Uncommon mutations have been reported primarily in <i>EGFR</i> and <i>BRAF</i> genes and are frequently associated with atypical clinical presentations. Here, we present a rare case of a patient affecte...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/15/7552 |
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| author | Marco De Felice Pasquale Pisapia Francesco Pepe Caterina De Luca Antonino Iaccarino Umberto Malapelle Giancarlo Troncone Giovanni Pietro Ianniello |
| author_facet | Marco De Felice Pasquale Pisapia Francesco Pepe Caterina De Luca Antonino Iaccarino Umberto Malapelle Giancarlo Troncone Giovanni Pietro Ianniello |
| author_sort | Marco De Felice |
| collection | DOAJ |
| description | Molecular profiling has revolutionized the treatment of metastatic NSCLC. Uncommon mutations have been reported primarily in <i>EGFR</i> and <i>BRAF</i> genes and are frequently associated with atypical clinical presentations. Here, we present a rare case of a patient affected by <i>BRAF</i> exon 15 p.K601E-mutated lung cancer with synchronous peritoneal carcinomatosis. First line treatment with chemo-immunotherapy combinations provided a PFS of 8–9 months, whereas a second line treatment with BRAF and MEK inhibitors elicited a dissociated response. The latter clinical outcome suggests that these inhibitors have only partial activity against this rare mutation. |
| first_indexed | 2024-03-09T05:37:04Z |
| format | Article |
| id | doaj.art-b90f9e0df9b8406ab3a6f33181113def |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T05:37:04Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-b90f9e0df9b8406ab3a6f33181113def2023-12-03T12:27:55ZengMDPI AGApplied Sciences2076-34172022-07-011215755210.3390/app12157552Unusual Clinical Experience in <i>BRAF</i> Exon 15 p.K601E-Mutated Lung Cancer: A Case Report and Brief Review of the LiteratureMarco De Felice0Pasquale Pisapia1Francesco Pepe2Caterina De Luca3Antonino Iaccarino4Umberto Malapelle5Giancarlo Troncone6Giovanni Pietro Ianniello7Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, 81100 Caserta, ItalyDepartment of Public Health, University of Naples Federico II, 80131 Naples, ItalyDepartment of Public Health, University of Naples Federico II, 80131 Naples, ItalyDepartment of Public Health, University of Naples Federico II, 80131 Naples, ItalyDepartment of Public Health, University of Naples Federico II, 80131 Naples, ItalyDepartment of Public Health, University of Naples Federico II, 80131 Naples, ItalyDepartment of Public Health, University of Naples Federico II, 80131 Naples, ItalyDivision of Oncology, AORN “Sant’ Anna e San Sebastiano”, 81100 Caserta, ItalyMolecular profiling has revolutionized the treatment of metastatic NSCLC. Uncommon mutations have been reported primarily in <i>EGFR</i> and <i>BRAF</i> genes and are frequently associated with atypical clinical presentations. Here, we present a rare case of a patient affected by <i>BRAF</i> exon 15 p.K601E-mutated lung cancer with synchronous peritoneal carcinomatosis. First line treatment with chemo-immunotherapy combinations provided a PFS of 8–9 months, whereas a second line treatment with BRAF and MEK inhibitors elicited a dissociated response. The latter clinical outcome suggests that these inhibitors have only partial activity against this rare mutation.https://www.mdpi.com/2076-3417/12/15/7552lung cancer<i>BRAF</i> exon 15 p.K601Etarget therapyimmunotherapyperitoneal carcinomatosis |
| spellingShingle | Marco De Felice Pasquale Pisapia Francesco Pepe Caterina De Luca Antonino Iaccarino Umberto Malapelle Giancarlo Troncone Giovanni Pietro Ianniello Unusual Clinical Experience in <i>BRAF</i> Exon 15 p.K601E-Mutated Lung Cancer: A Case Report and Brief Review of the Literature Applied Sciences lung cancer <i>BRAF</i> exon 15 p.K601E target therapy immunotherapy peritoneal carcinomatosis |
| title | Unusual Clinical Experience in <i>BRAF</i> Exon 15 p.K601E-Mutated Lung Cancer: A Case Report and Brief Review of the Literature |
| title_full | Unusual Clinical Experience in <i>BRAF</i> Exon 15 p.K601E-Mutated Lung Cancer: A Case Report and Brief Review of the Literature |
| title_fullStr | Unusual Clinical Experience in <i>BRAF</i> Exon 15 p.K601E-Mutated Lung Cancer: A Case Report and Brief Review of the Literature |
| title_full_unstemmed | Unusual Clinical Experience in <i>BRAF</i> Exon 15 p.K601E-Mutated Lung Cancer: A Case Report and Brief Review of the Literature |
| title_short | Unusual Clinical Experience in <i>BRAF</i> Exon 15 p.K601E-Mutated Lung Cancer: A Case Report and Brief Review of the Literature |
| title_sort | unusual clinical experience in i braf i exon 15 p k601e mutated lung cancer a case report and brief review of the literature |
| topic | lung cancer <i>BRAF</i> exon 15 p.K601E target therapy immunotherapy peritoneal carcinomatosis |
| url | https://www.mdpi.com/2076-3417/12/15/7552 |
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