NVCL-Based Galacto-Functionalized and Thermosensitive Nanogels with GNRDs for Chemo/Photothermal-Therapy
Dual-function nanogels (particle size from 98 to 224 nm) synthesized via surfactant-free emulsion polymerization (SFEP) were tested as smart carriers toward synergistic chemo- and photothermal therapy. Cisplatin (CDDP) or doxorubicin (DOX) and gold nanorods (GNRDs) were loaded into galacto-functiona...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/3/560 |
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| author | Mirian A. González-Ayón Jacob Licea-Rodriguez Eugenio R. Méndez Angel Licea-Claverie |
| author_facet | Mirian A. González-Ayón Jacob Licea-Rodriguez Eugenio R. Méndez Angel Licea-Claverie |
| author_sort | Mirian A. González-Ayón |
| collection | DOAJ |
| description | Dual-function nanogels (particle size from 98 to 224 nm) synthesized via surfactant-free emulsion polymerization (SFEP) were tested as smart carriers toward synergistic chemo- and photothermal therapy. Cisplatin (CDDP) or doxorubicin (DOX) and gold nanorods (GNRDs) were loaded into galacto-functionalized PNVCL-based nanogels, where the encapsulation efficiency for CDDP and DOX was around 64 and 52%, respectively. PNVCL-based nanogels were proven to be an efficient delivery vehicle under conditions that mimic the tumor site in vitro. The release of CDDP or DOX was slower at pH 7.4 and 37 °C than at tumor conditions of pH 6 and 40 °C. On the other hand, in the systems with GNRDs at pH 7.4 and 37 °C, the sample was irradiated with a 785 nm laser for 10 min every hour, obtaining that the release profiles were even higher than in the conditions that simulated a cancer tissue (without irradiation). Thus, the present study demonstrates the synergistic effect of chemo- and photothermal therapy as a promising dual function in the potential future use of PNVCL nanogels loaded with GNRDs and CDDP/DOX to achieve an enhanced chemo/phototherapy in vivo. |
| first_indexed | 2024-03-09T12:59:08Z |
| format | Article |
| id | doaj.art-b911921f9cc8418bbfd7c137b5789e2b |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T12:59:08Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-b911921f9cc8418bbfd7c137b5789e2b2023-11-30T21:56:37ZengMDPI AGPharmaceutics1999-49232022-03-0114356010.3390/pharmaceutics14030560NVCL-Based Galacto-Functionalized and Thermosensitive Nanogels with GNRDs for Chemo/Photothermal-TherapyMirian A. González-Ayón0Jacob Licea-Rodriguez1Eugenio R. Méndez2Angel Licea-Claverie3Centro de Graduados e Investigación en Química, Tecnológico Nacional de México/Instituto Tecnológico de Tijuana, Apartado Postal 1166, Tijuana 22454, MexicoDivisión de Física Aplicada, Centro de Investigación Científica y Educación Superior de Ensenada, Carretera Ensenada-Tijuana No. 3918, Ensenada 22860, B. C., MexicoDivisión de Física Aplicada, Centro de Investigación Científica y Educación Superior de Ensenada, Carretera Ensenada-Tijuana No. 3918, Ensenada 22860, B. C., MexicoCentro de Graduados e Investigación en Química, Tecnológico Nacional de México/Instituto Tecnológico de Tijuana, Apartado Postal 1166, Tijuana 22454, MexicoDual-function nanogels (particle size from 98 to 224 nm) synthesized via surfactant-free emulsion polymerization (SFEP) were tested as smart carriers toward synergistic chemo- and photothermal therapy. Cisplatin (CDDP) or doxorubicin (DOX) and gold nanorods (GNRDs) were loaded into galacto-functionalized PNVCL-based nanogels, where the encapsulation efficiency for CDDP and DOX was around 64 and 52%, respectively. PNVCL-based nanogels were proven to be an efficient delivery vehicle under conditions that mimic the tumor site in vitro. The release of CDDP or DOX was slower at pH 7.4 and 37 °C than at tumor conditions of pH 6 and 40 °C. On the other hand, in the systems with GNRDs at pH 7.4 and 37 °C, the sample was irradiated with a 785 nm laser for 10 min every hour, obtaining that the release profiles were even higher than in the conditions that simulated a cancer tissue (without irradiation). Thus, the present study demonstrates the synergistic effect of chemo- and photothermal therapy as a promising dual function in the potential future use of PNVCL nanogels loaded with GNRDs and CDDP/DOX to achieve an enhanced chemo/phototherapy in vivo.https://www.mdpi.com/1999-4923/14/3/560nanogelsgold nanorodcisplatindoxorubicinchemo- and photothermal therapy |
| spellingShingle | Mirian A. González-Ayón Jacob Licea-Rodriguez Eugenio R. Méndez Angel Licea-Claverie NVCL-Based Galacto-Functionalized and Thermosensitive Nanogels with GNRDs for Chemo/Photothermal-Therapy Pharmaceutics nanogels gold nanorod cisplatin doxorubicin chemo- and photothermal therapy |
| title | NVCL-Based Galacto-Functionalized and Thermosensitive Nanogels with GNRDs for Chemo/Photothermal-Therapy |
| title_full | NVCL-Based Galacto-Functionalized and Thermosensitive Nanogels with GNRDs for Chemo/Photothermal-Therapy |
| title_fullStr | NVCL-Based Galacto-Functionalized and Thermosensitive Nanogels with GNRDs for Chemo/Photothermal-Therapy |
| title_full_unstemmed | NVCL-Based Galacto-Functionalized and Thermosensitive Nanogels with GNRDs for Chemo/Photothermal-Therapy |
| title_short | NVCL-Based Galacto-Functionalized and Thermosensitive Nanogels with GNRDs for Chemo/Photothermal-Therapy |
| title_sort | nvcl based galacto functionalized and thermosensitive nanogels with gnrds for chemo photothermal therapy |
| topic | nanogels gold nanorod cisplatin doxorubicin chemo- and photothermal therapy |
| url | https://www.mdpi.com/1999-4923/14/3/560 |
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