Multiple Endocrine Neoplasia in Childhood: An Update on Diagnosis, Screening, Management and Treatment
Multiple endocrine neoplasia (MEN) is a group of heterogenous syndromes characterized by the occurrence of two or more endocrine gland tumors in a patient or related individuals in the same family. They are inherited in an autosomal dominant fashion and are highly penetrant. There are three types of...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Endocrines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-396X/3/1/7 |
| _version_ | 1797471884901613568 |
|---|---|
| author | Marianne Jacob Dustin Rowland Oksana Lekarev Berrin Ergun-Longmire |
| author_facet | Marianne Jacob Dustin Rowland Oksana Lekarev Berrin Ergun-Longmire |
| author_sort | Marianne Jacob |
| collection | DOAJ |
| description | Multiple endocrine neoplasia (MEN) is a group of heterogenous syndromes characterized by the occurrence of two or more endocrine gland tumors in a patient or related individuals in the same family. They are inherited in an autosomal dominant fashion and are highly penetrant. There are three types of MEN syndromes: MEN type 1 (MEN1), MEN type 2 (MEN2), and MEN type 4 (MEN4). MEN2 is further divided into MEN2A, MEN2B (formerly known MEN3), and familial medullary thyroid carcinoma (FMTC). Although MEN syndromes are rare, it is crucial to identify individuals at risk for potentially life-threatening neoplasias. This review article provides an update on each MEN syndrome, its genetics, diagnosis, and management in children. |
| first_indexed | 2024-03-09T19:54:25Z |
| format | Article |
| id | doaj.art-b911fb2ec95e4b91bb25283bdc54a549 |
| institution | Directory Open Access Journal |
| issn | 2673-396X |
| language | English |
| last_indexed | 2024-03-09T19:54:25Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Endocrines |
| spelling | doaj.art-b911fb2ec95e4b91bb25283bdc54a5492023-11-24T01:02:03ZengMDPI AGEndocrines2673-396X2022-02-0131769110.3390/endocrines3010007Multiple Endocrine Neoplasia in Childhood: An Update on Diagnosis, Screening, Management and TreatmentMarianne Jacob0Dustin Rowland1Oksana Lekarev2Berrin Ergun-Longmire3Division of Pediatric Endocrinology, Department of Pediatrics, Weill Cornell Medicine, NewYork-Presbyterian Hospital, 505 East 70th Street, New York, NY 10021, USADepartment of Pediatric & Adolescent Medicine, Homer Stryker M.D. School of Medicine, Western Michigan University, 1000 Oakland Drive, Kalamazoo, MI 49008, USADivision of Pediatric Endocrinology, Department of Pediatrics, Weill Cornell Medicine, NewYork-Presbyterian Hospital, 505 East 70th Street, New York, NY 10021, USADepartment of Pediatric & Adolescent Medicine, Homer Stryker M.D. School of Medicine, Western Michigan University, 1000 Oakland Drive, Kalamazoo, MI 49008, USAMultiple endocrine neoplasia (MEN) is a group of heterogenous syndromes characterized by the occurrence of two or more endocrine gland tumors in a patient or related individuals in the same family. They are inherited in an autosomal dominant fashion and are highly penetrant. There are three types of MEN syndromes: MEN type 1 (MEN1), MEN type 2 (MEN2), and MEN type 4 (MEN4). MEN2 is further divided into MEN2A, MEN2B (formerly known MEN3), and familial medullary thyroid carcinoma (FMTC). Although MEN syndromes are rare, it is crucial to identify individuals at risk for potentially life-threatening neoplasias. This review article provides an update on each MEN syndrome, its genetics, diagnosis, and management in children.https://www.mdpi.com/2673-396X/3/1/7multiple endocrine neoplasiaMEN1MEN2AMEN2BMEN4familial medullary thyroid carcinoma |
| spellingShingle | Marianne Jacob Dustin Rowland Oksana Lekarev Berrin Ergun-Longmire Multiple Endocrine Neoplasia in Childhood: An Update on Diagnosis, Screening, Management and Treatment Endocrines multiple endocrine neoplasia MEN1 MEN2A MEN2B MEN4 familial medullary thyroid carcinoma |
| title | Multiple Endocrine Neoplasia in Childhood: An Update on Diagnosis, Screening, Management and Treatment |
| title_full | Multiple Endocrine Neoplasia in Childhood: An Update on Diagnosis, Screening, Management and Treatment |
| title_fullStr | Multiple Endocrine Neoplasia in Childhood: An Update on Diagnosis, Screening, Management and Treatment |
| title_full_unstemmed | Multiple Endocrine Neoplasia in Childhood: An Update on Diagnosis, Screening, Management and Treatment |
| title_short | Multiple Endocrine Neoplasia in Childhood: An Update on Diagnosis, Screening, Management and Treatment |
| title_sort | multiple endocrine neoplasia in childhood an update on diagnosis screening management and treatment |
| topic | multiple endocrine neoplasia MEN1 MEN2A MEN2B MEN4 familial medullary thyroid carcinoma |
| url | https://www.mdpi.com/2673-396X/3/1/7 |
| work_keys_str_mv | AT mariannejacob multipleendocrineneoplasiainchildhoodanupdateondiagnosisscreeningmanagementandtreatment AT dustinrowland multipleendocrineneoplasiainchildhoodanupdateondiagnosisscreeningmanagementandtreatment AT oksanalekarev multipleendocrineneoplasiainchildhoodanupdateondiagnosisscreeningmanagementandtreatment AT berrinergunlongmire multipleendocrineneoplasiainchildhoodanupdateondiagnosisscreeningmanagementandtreatment |