POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East

POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East

Abstract Background Colorectal cancer (CRC) is a major contributor to morbidity and mortality related to cancer. Only ~5% of all CRCs occur as a result of pathogenic variants in well‐defined CRC predisposing genes. The frequency and effect of exonuclease domain pathogenic variants of POLE and POLD1...

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Bibliographic Details
Main Authors: Abdul K. Siraj, Rong Bu, Kaleem Iqbal, Sandeep K. Parvathareddy, Tariq Masoodi, Nabil Siraj, Maha Al‐Rasheed, Yan Kong, Saeeda O. Ahmed, Khadija A. S. Al‐Obaisi, Ingrid G. Victoria, Maham Arshad, Fouad Al‐Dayel, Alaa Abduljabbar, Luai H. Ashari, Khawla S. Al‐Kuraya
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
colorectal cancers
Middle East
POLD1
POLE
variant
Online Access:https://doi.org/10.1002/mgg3.1368

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