Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody
G protein-coupled receptors (GPCRs) are integral membrane proteins and the largest class of drug targets in the human genome. Here, Baidya et al. show that a synthetic antibody can be used to modulate GPCR trafficking and signaling in live cells.
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32386-x |
| _version_ | 1818499060875657216 |
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| author | Mithu Baidya Madhu Chaturvedi Hemlata Dwivedi-Agnihotri Ashutosh Ranjan Dominic Devost Yoon Namkung Tomasz Maciej Stepniewski Shubhi Pandey Minakshi Baruah Bhanupriya Panigrahi Parishmita Sarma Manish K. Yadav Jagannath Maharana Ramanuj Banerjee Kouki Kawakami Asuka Inoue Jana Selent Stéphane A. Laporte Terence E. Hébert Arun K. Shukla |
| author_facet | Mithu Baidya Madhu Chaturvedi Hemlata Dwivedi-Agnihotri Ashutosh Ranjan Dominic Devost Yoon Namkung Tomasz Maciej Stepniewski Shubhi Pandey Minakshi Baruah Bhanupriya Panigrahi Parishmita Sarma Manish K. Yadav Jagannath Maharana Ramanuj Banerjee Kouki Kawakami Asuka Inoue Jana Selent Stéphane A. Laporte Terence E. Hébert Arun K. Shukla |
| author_sort | Mithu Baidya |
| collection | DOAJ |
| description | G protein-coupled receptors (GPCRs) are integral membrane proteins and the largest class of drug targets in the human genome. Here, Baidya et al. show that a synthetic antibody can be used to modulate GPCR trafficking and signaling in live cells. |
| first_indexed | 2024-12-10T20:24:08Z |
| format | Article |
| id | doaj.art-b914c159b8f9404cb1ff77ff55de3886 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-10T20:24:08Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b914c159b8f9404cb1ff77ff55de38862022-12-22T01:34:56ZengNature PortfolioNature Communications2041-17232022-08-0113111810.1038/s41467-022-32386-xAllosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabodyMithu Baidya0Madhu Chaturvedi1Hemlata Dwivedi-Agnihotri2Ashutosh Ranjan3Dominic Devost4Yoon Namkung5Tomasz Maciej Stepniewski6Shubhi Pandey7Minakshi Baruah8Bhanupriya Panigrahi9Parishmita Sarma10Manish K. Yadav11Jagannath Maharana12Ramanuj Banerjee13Kouki Kawakami14Asuka Inoue15Jana Selent16Stéphane A. Laporte17Terence E. Hébert18Arun K. Shukla19Department of Biological Sciences and Bioengineering, Indian Institute of TechnologyDepartment of Biological Sciences and Bioengineering, Indian Institute of TechnologyDepartment of Biological Sciences and Bioengineering, Indian Institute of TechnologyDepartment of Biological Sciences and Bioengineering, Indian Institute of TechnologyDepartment of Pharmacology and Therapeutics, McGill UniversityDepartment of Medicine, McGill University Health Center, McGill UniversityResearch Program on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM)Department of Biological Sciences and Bioengineering, Indian Institute of TechnologyDepartment of Biological Sciences and Bioengineering, Indian Institute of TechnologyDepartment of Biological Sciences and Bioengineering, Indian Institute of TechnologyDepartment of Biological Sciences and Bioengineering, Indian Institute of TechnologyDepartment of Biological Sciences and Bioengineering, Indian Institute of TechnologyDepartment of Biological Sciences and Bioengineering, Indian Institute of TechnologyDepartment of Biological Sciences and Bioengineering, Indian Institute of TechnologyGraduate School of Pharmaceutical Sciences, Tohoku UniversityGraduate School of Pharmaceutical Sciences, Tohoku UniversityResearch Program on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM)Department of Pharmacology and Therapeutics, McGill UniversityDepartment of Pharmacology and Therapeutics, McGill UniversityDepartment of Biological Sciences and Bioengineering, Indian Institute of TechnologyG protein-coupled receptors (GPCRs) are integral membrane proteins and the largest class of drug targets in the human genome. Here, Baidya et al. show that a synthetic antibody can be used to modulate GPCR trafficking and signaling in live cells.https://doi.org/10.1038/s41467-022-32386-x |
| spellingShingle | Mithu Baidya Madhu Chaturvedi Hemlata Dwivedi-Agnihotri Ashutosh Ranjan Dominic Devost Yoon Namkung Tomasz Maciej Stepniewski Shubhi Pandey Minakshi Baruah Bhanupriya Panigrahi Parishmita Sarma Manish K. Yadav Jagannath Maharana Ramanuj Banerjee Kouki Kawakami Asuka Inoue Jana Selent Stéphane A. Laporte Terence E. Hébert Arun K. Shukla Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody Nature Communications |
| title | Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody |
| title_full | Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody |
| title_fullStr | Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody |
| title_full_unstemmed | Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody |
| title_short | Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody |
| title_sort | allosteric modulation of gpcr induced β arrestin trafficking and signaling by a synthetic intrabody |
| url | https://doi.org/10.1038/s41467-022-32386-x |
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