Anti-IL5 Therapies for Severe Eosinophilic Asthma: Literature Review and Practical Insights
Francesco Menzella,1 Patrizia Ruggiero,1 Giulia Ghidoni,1 Matteo Fontana,1 Diego Bagnasco,2 Francesco Livrieri,1 Chiara Scelfo,1 Nicola Facciolongo1 1Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL di Reggio Emilia-IRCCS, Reggio Emilia 42123, Italy; 2Allergy & Respiratory Disease...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-09-01
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| Series: | Journal of Asthma and Allergy |
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| Online Access: | https://www.dovepress.com/anti-il5-therapies-for-severe-eosinophilic-asthma-literature-review-an-peer-reviewed-article-JAA |
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| author | Menzella F Ruggiero P Ghidoni G Fontana M Bagnasco D Livrieri F Scelfo C Facciolongo N |
| author_facet | Menzella F Ruggiero P Ghidoni G Fontana M Bagnasco D Livrieri F Scelfo C Facciolongo N |
| author_sort | Menzella F |
| collection | DOAJ |
| description | Francesco Menzella,1 Patrizia Ruggiero,1 Giulia Ghidoni,1 Matteo Fontana,1 Diego Bagnasco,2 Francesco Livrieri,1 Chiara Scelfo,1 Nicola Facciolongo1 1Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL di Reggio Emilia-IRCCS, Reggio Emilia 42123, Italy; 2Allergy & Respiratory Diseases, University of Genoa, Genoa 16132, ItalyCorrespondence: Francesco MenzellaPneumology Unit, Santa Maria Nuova Hospital, Azienda USL-IRCCS di Reggio Emilia, Via Amendola 2, Reggio Emilia 42122, ItalyEmail francesco.menzella@ausl.re.itAbstract: Severe refractory asthma (SRA) still has a high economic and social impact, including a reduction in quality of life (QoL), productivity, a greater risk of exacerbations and emergency department (ED) visits. Another major issue is the need of oral corticosteroids (OCS), often due to a poor response to standard therapies or the lack of indication for currently available biological drugs. A thorough understanding of the immunological pathways and eosinophilopoietic processes allows a correct application of the new pharmacological strategies and leads to better clinical responses. For these unmet needs, several monoclonal antibody (mAb) drugs have been introduced over the past few years. These are mainly available for allergic and especially eosinophilic uncontrolled refractory asthma. As the number of therapeutic options increases, the choice of biological drugs can be made only after careful considerations of the particular asthma endotype, patients’ comorbidities and clinical data. The selection of the correct therapeutic option can therefore be guided after a careful evaluation of the particular endotype and phenotype, from the combined evaluation of inflammatory biomarkers, clinical picture and comorbidities. The careful evaluation of all these parameters can therefore help the physician in the optimal management of these complex patients, for whom it is often possible to achieve exceptional results by managing the available options in the best possible way. The aim of this review is to define the positioning of the biological drugs currently available for type 2 asthma, with a special focus on options for eosinophilic asthma in the context of the most recent knowledge of immunological pathways.Keywords: severe refractory asthma, eosinophilia, IL-5, biomarkers, oral corticosteroids, pandemic |
| first_indexed | 2024-12-13T06:11:11Z |
| format | Article |
| id | doaj.art-b9177711c62e4393a1bc3328443f8b20 |
| institution | Directory Open Access Journal |
| issn | 1178-6965 |
| language | English |
| last_indexed | 2024-12-13T06:11:11Z |
| publishDate | 2020-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Asthma and Allergy |
| spelling | doaj.art-b9177711c62e4393a1bc3328443f8b202022-12-21T23:57:05ZengDove Medical PressJournal of Asthma and Allergy1178-69652020-09-01Volume 1330131356866Anti-IL5 Therapies for Severe Eosinophilic Asthma: Literature Review and Practical InsightsMenzella FRuggiero PGhidoni GFontana MBagnasco DLivrieri FScelfo CFacciolongo NFrancesco Menzella,1 Patrizia Ruggiero,1 Giulia Ghidoni,1 Matteo Fontana,1 Diego Bagnasco,2 Francesco Livrieri,1 Chiara Scelfo,1 Nicola Facciolongo1 1Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL di Reggio Emilia-IRCCS, Reggio Emilia 42123, Italy; 2Allergy & Respiratory Diseases, University of Genoa, Genoa 16132, ItalyCorrespondence: Francesco MenzellaPneumology Unit, Santa Maria Nuova Hospital, Azienda USL-IRCCS di Reggio Emilia, Via Amendola 2, Reggio Emilia 42122, ItalyEmail francesco.menzella@ausl.re.itAbstract: Severe refractory asthma (SRA) still has a high economic and social impact, including a reduction in quality of life (QoL), productivity, a greater risk of exacerbations and emergency department (ED) visits. Another major issue is the need of oral corticosteroids (OCS), often due to a poor response to standard therapies or the lack of indication for currently available biological drugs. A thorough understanding of the immunological pathways and eosinophilopoietic processes allows a correct application of the new pharmacological strategies and leads to better clinical responses. For these unmet needs, several monoclonal antibody (mAb) drugs have been introduced over the past few years. These are mainly available for allergic and especially eosinophilic uncontrolled refractory asthma. As the number of therapeutic options increases, the choice of biological drugs can be made only after careful considerations of the particular asthma endotype, patients’ comorbidities and clinical data. The selection of the correct therapeutic option can therefore be guided after a careful evaluation of the particular endotype and phenotype, from the combined evaluation of inflammatory biomarkers, clinical picture and comorbidities. The careful evaluation of all these parameters can therefore help the physician in the optimal management of these complex patients, for whom it is often possible to achieve exceptional results by managing the available options in the best possible way. The aim of this review is to define the positioning of the biological drugs currently available for type 2 asthma, with a special focus on options for eosinophilic asthma in the context of the most recent knowledge of immunological pathways.Keywords: severe refractory asthma, eosinophilia, IL-5, biomarkers, oral corticosteroids, pandemichttps://www.dovepress.com/anti-il5-therapies-for-severe-eosinophilic-asthma-literature-review-an-peer-reviewed-article-JAAsevere refractory asthmaeosinophiliail-5biomarkersoral corticosteroidspandemic |
| spellingShingle | Menzella F Ruggiero P Ghidoni G Fontana M Bagnasco D Livrieri F Scelfo C Facciolongo N Anti-IL5 Therapies for Severe Eosinophilic Asthma: Literature Review and Practical Insights Journal of Asthma and Allergy severe refractory asthma eosinophilia il-5 biomarkers oral corticosteroids pandemic |
| title | Anti-IL5 Therapies for Severe Eosinophilic Asthma: Literature Review and Practical Insights |
| title_full | Anti-IL5 Therapies for Severe Eosinophilic Asthma: Literature Review and Practical Insights |
| title_fullStr | Anti-IL5 Therapies for Severe Eosinophilic Asthma: Literature Review and Practical Insights |
| title_full_unstemmed | Anti-IL5 Therapies for Severe Eosinophilic Asthma: Literature Review and Practical Insights |
| title_short | Anti-IL5 Therapies for Severe Eosinophilic Asthma: Literature Review and Practical Insights |
| title_sort | anti il5 therapies for severe eosinophilic asthma literature review and practical insights |
| topic | severe refractory asthma eosinophilia il-5 biomarkers oral corticosteroids pandemic |
| url | https://www.dovepress.com/anti-il5-therapies-for-severe-eosinophilic-asthma-literature-review-an-peer-reviewed-article-JAA |
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