Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in Healthy Women: A Randomized Controlled and Crossover Study
This is a follow-up of our previous postprandial study and it focused on the plasma lipidomic responses to 30 days of krill oil (KO) versus fish oil (FO) supplementations in healthy women. Eleven women (aged 18–50 years) consumed KO or FO for 30 days in a randomized, cross-over study, with at least...
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MDPI AG
2020-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/9/2804 |
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| author | Hyunsin H. Sung Andrew J. Sinclair Kevin Huynh Adam A. T. Smith Natalie A. Mellett Peter J. Meikle Xiao Q. Su |
| author_facet | Hyunsin H. Sung Andrew J. Sinclair Kevin Huynh Adam A. T. Smith Natalie A. Mellett Peter J. Meikle Xiao Q. Su |
| author_sort | Hyunsin H. Sung |
| collection | DOAJ |
| description | This is a follow-up of our previous postprandial study and it focused on the plasma lipidomic responses to 30 days of krill oil (KO) versus fish oil (FO) supplementations in healthy women. Eleven women (aged 18–50 years) consumed KO or FO for 30 days in a randomized, cross-over study, with at least a four-week washout period between supplementations. The daily supplements provided 1.27 g/day of long-chain (LC) omega-3 polyunsaturated fatty acids (PUFA) from KO (containing 0.76 g eicosapentaenoic acid (EPA), 0.42 g docosahexaenoic acid (DHA)) and 1.44 g/day from FO (containing 0.79 g EPA, 0.47 g DHA). Fasting plasma samples at days 0, 15, and 30 were analyzed using gas chromatography and liquid chromatography electrospray ionisation-tandem mass spectrometry. KO resulted in a significantly greater relative area under the curve (relAUC) for plasma EPA after 30 days. Lipidomic analysis showed that 26 of 43 lipid molecular species had a significantly greater relAUC in the KO group, while 17/43 showed a significantly lower relAUC compared with the FO group. More than 38% of the lipids species which increased more following KO contained omega-3 PUFA, while where FO was greater than KO, only 12% contained omega-3 PUFA. These data show that KO and FO do not have equivalent effects on the plasma lipidome. |
| first_indexed | 2024-03-10T16:21:53Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T16:21:53Z |
| publishDate | 2020-09-01 |
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| series | Nutrients |
| spelling | doaj.art-b9190320131144c5bd658476b6cebb722023-11-20T13:35:06ZengMDPI AGNutrients2072-66432020-09-01129280410.3390/nu12092804Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in Healthy Women: A Randomized Controlled and Crossover StudyHyunsin H. Sung0Andrew J. Sinclair1Kevin Huynh2Adam A. T. Smith3Natalie A. Mellett4Peter J. Meikle5Xiao Q. Su6Institute for Health and Sport, Victoria University, P.O. Box 14428, Melbourne, VIC 8001, AustraliaFaculty of Health, Deakin University, Geelong, VIC 3217, AustraliaMetabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, AustraliaMetabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, AustraliaMetabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, AustraliaMetabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, AustraliaInstitute for Health and Sport, Victoria University, P.O. Box 14428, Melbourne, VIC 8001, AustraliaThis is a follow-up of our previous postprandial study and it focused on the plasma lipidomic responses to 30 days of krill oil (KO) versus fish oil (FO) supplementations in healthy women. Eleven women (aged 18–50 years) consumed KO or FO for 30 days in a randomized, cross-over study, with at least a four-week washout period between supplementations. The daily supplements provided 1.27 g/day of long-chain (LC) omega-3 polyunsaturated fatty acids (PUFA) from KO (containing 0.76 g eicosapentaenoic acid (EPA), 0.42 g docosahexaenoic acid (DHA)) and 1.44 g/day from FO (containing 0.79 g EPA, 0.47 g DHA). Fasting plasma samples at days 0, 15, and 30 were analyzed using gas chromatography and liquid chromatography electrospray ionisation-tandem mass spectrometry. KO resulted in a significantly greater relative area under the curve (relAUC) for plasma EPA after 30 days. Lipidomic analysis showed that 26 of 43 lipid molecular species had a significantly greater relAUC in the KO group, while 17/43 showed a significantly lower relAUC compared with the FO group. More than 38% of the lipids species which increased more following KO contained omega-3 PUFA, while where FO was greater than KO, only 12% contained omega-3 PUFA. These data show that KO and FO do not have equivalent effects on the plasma lipidome.https://www.mdpi.com/2072-6643/12/9/2804krill oilfish oilplasma lipidomic responseEPADHAphospholipids |
| spellingShingle | Hyunsin H. Sung Andrew J. Sinclair Kevin Huynh Adam A. T. Smith Natalie A. Mellett Peter J. Meikle Xiao Q. Su Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in Healthy Women: A Randomized Controlled and Crossover Study Nutrients krill oil fish oil plasma lipidomic response EPA DHA phospholipids |
| title | Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in Healthy Women: A Randomized Controlled and Crossover Study |
| title_full | Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in Healthy Women: A Randomized Controlled and Crossover Study |
| title_fullStr | Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in Healthy Women: A Randomized Controlled and Crossover Study |
| title_full_unstemmed | Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in Healthy Women: A Randomized Controlled and Crossover Study |
| title_short | Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in Healthy Women: A Randomized Controlled and Crossover Study |
| title_sort | krill oil has different effects on the plasma lipidome compared with fish oil following 30 days of supplementation in healthy women a randomized controlled and crossover study |
| topic | krill oil fish oil plasma lipidomic response EPA DHA phospholipids |
| url | https://www.mdpi.com/2072-6643/12/9/2804 |
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