| Summary: | To ensure the country’s sustainable health recovery, viruses like COVID-19 need faster detection and sampling than the rate at which they spread. Blood plasma has proven to be an important and better clinical sample for the detection and diagnosis of various medical conditions as compared to whole blood. For in situ and in vivo health monitoring, plasma can be easily processed through microfluidic Lab-on-Chip (LOC) devices without the clotting that shortens the turnaround time and using minimum amounts of sample and reagents. The present review discusses the key properties of blood plasma as a perfect sample for the microfluidic LOC devices and the importance of passive plasma separators within any kind of LOC device as an embedded unit. The passive LOC plasma separators offer rapid extraction without external forces in the form of a miniaturized automated unit. This article compares various plasma separators on the basis of plasma extraction efficiency, fabrication techniques, and separation science utilized for hemolysis-free extraction. Recent developments in the area of passive bioseparators based on microfiltration and self-driven hydrodynamic and flow-cytometric approaches are discussed in detail.
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