Meta-analysis of the prognostic significance of FOXC2 in various tumors

Objective Many studies have focused on correlations between forkhead box protein C2 (FOXC2) and various tumors but discrepant results have been reported. Thus, we conducted this meta-analysis to assess the prognostic role of FOXC2 in tumors. Methods Four electronic databases (PubMed, Embase, Web of...

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Main Authors: Bixia Xu, Yun Tian, Lin Liu
Format: Article
Language:English
Published: SAGE Publishing 2020-10-01
Series:Journal of International Medical Research
Online Access:https://doi.org/10.1177/0300060519891648
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author Bixia Xu
Yun Tian
Lin Liu
author_facet Bixia Xu
Yun Tian
Lin Liu
author_sort Bixia Xu
collection DOAJ
description Objective Many studies have focused on correlations between forkhead box protein C2 (FOXC2) and various tumors but discrepant results have been reported. Thus, we conducted this meta-analysis to assess the prognostic role of FOXC2 in tumors. Methods Four electronic databases (PubMed, Embase, Web of Science, and SinoMed) were screened through September 2019. Results The final analysis included 15 reports and 2115 patients; results suggested that cancer patients with FOXC2 had worse overall survival (hazard ratio 2.14, 95% confidence interval (CI) 1.74–2.64), cancer-specific survival (hazard ratio 2.65, 95% CI 1.44–4.89), and disease-free survival (hazard ratio 1.93, 95% CI 1.49–2.50) than patients lacking FOXC2. Conclusions The presence of FOXC2 was associated with poor survival in cancer patients. FOXC2 could be a promising prognostic marker in the future.
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spelling doaj.art-b9196eaa6a6f46099d6d3192470f09af2022-12-21T19:28:24ZengSAGE PublishingJournal of International Medical Research1473-23002020-10-014810.1177/0300060519891648Meta-analysis of the prognostic significance of FOXC2 in various tumorsBixia XuYun TianLin LiuObjective Many studies have focused on correlations between forkhead box protein C2 (FOXC2) and various tumors but discrepant results have been reported. Thus, we conducted this meta-analysis to assess the prognostic role of FOXC2 in tumors. Methods Four electronic databases (PubMed, Embase, Web of Science, and SinoMed) were screened through September 2019. Results The final analysis included 15 reports and 2115 patients; results suggested that cancer patients with FOXC2 had worse overall survival (hazard ratio 2.14, 95% confidence interval (CI) 1.74–2.64), cancer-specific survival (hazard ratio 2.65, 95% CI 1.44–4.89), and disease-free survival (hazard ratio 1.93, 95% CI 1.49–2.50) than patients lacking FOXC2. Conclusions The presence of FOXC2 was associated with poor survival in cancer patients. FOXC2 could be a promising prognostic marker in the future.https://doi.org/10.1177/0300060519891648
spellingShingle Bixia Xu
Yun Tian
Lin Liu
Meta-analysis of the prognostic significance of FOXC2 in various tumors
Journal of International Medical Research
title Meta-analysis of the prognostic significance of FOXC2 in various tumors
title_full Meta-analysis of the prognostic significance of FOXC2 in various tumors
title_fullStr Meta-analysis of the prognostic significance of FOXC2 in various tumors
title_full_unstemmed Meta-analysis of the prognostic significance of FOXC2 in various tumors
title_short Meta-analysis of the prognostic significance of FOXC2 in various tumors
title_sort meta analysis of the prognostic significance of foxc2 in various tumors
url https://doi.org/10.1177/0300060519891648
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AT yuntian metaanalysisoftheprognosticsignificanceoffoxc2invarioustumors
AT linliu metaanalysisoftheprognosticsignificanceoffoxc2invarioustumors