Meta-analysis of the prognostic significance of FOXC2 in various tumors
Objective Many studies have focused on correlations between forkhead box protein C2 (FOXC2) and various tumors but discrepant results have been reported. Thus, we conducted this meta-analysis to assess the prognostic role of FOXC2 in tumors. Methods Four electronic databases (PubMed, Embase, Web of...
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Format: | Article |
Language: | English |
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SAGE Publishing
2020-10-01
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Series: | Journal of International Medical Research |
Online Access: | https://doi.org/10.1177/0300060519891648 |
_version_ | 1818989917900898304 |
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author | Bixia Xu Yun Tian Lin Liu |
author_facet | Bixia Xu Yun Tian Lin Liu |
author_sort | Bixia Xu |
collection | DOAJ |
description | Objective Many studies have focused on correlations between forkhead box protein C2 (FOXC2) and various tumors but discrepant results have been reported. Thus, we conducted this meta-analysis to assess the prognostic role of FOXC2 in tumors. Methods Four electronic databases (PubMed, Embase, Web of Science, and SinoMed) were screened through September 2019. Results The final analysis included 15 reports and 2115 patients; results suggested that cancer patients with FOXC2 had worse overall survival (hazard ratio 2.14, 95% confidence interval (CI) 1.74–2.64), cancer-specific survival (hazard ratio 2.65, 95% CI 1.44–4.89), and disease-free survival (hazard ratio 1.93, 95% CI 1.49–2.50) than patients lacking FOXC2. Conclusions The presence of FOXC2 was associated with poor survival in cancer patients. FOXC2 could be a promising prognostic marker in the future. |
first_indexed | 2024-12-20T19:46:06Z |
format | Article |
id | doaj.art-b9196eaa6a6f46099d6d3192470f09af |
institution | Directory Open Access Journal |
issn | 1473-2300 |
language | English |
last_indexed | 2024-12-20T19:46:06Z |
publishDate | 2020-10-01 |
publisher | SAGE Publishing |
record_format | Article |
series | Journal of International Medical Research |
spelling | doaj.art-b9196eaa6a6f46099d6d3192470f09af2022-12-21T19:28:24ZengSAGE PublishingJournal of International Medical Research1473-23002020-10-014810.1177/0300060519891648Meta-analysis of the prognostic significance of FOXC2 in various tumorsBixia XuYun TianLin LiuObjective Many studies have focused on correlations between forkhead box protein C2 (FOXC2) and various tumors but discrepant results have been reported. Thus, we conducted this meta-analysis to assess the prognostic role of FOXC2 in tumors. Methods Four electronic databases (PubMed, Embase, Web of Science, and SinoMed) were screened through September 2019. Results The final analysis included 15 reports and 2115 patients; results suggested that cancer patients with FOXC2 had worse overall survival (hazard ratio 2.14, 95% confidence interval (CI) 1.74–2.64), cancer-specific survival (hazard ratio 2.65, 95% CI 1.44–4.89), and disease-free survival (hazard ratio 1.93, 95% CI 1.49–2.50) than patients lacking FOXC2. Conclusions The presence of FOXC2 was associated with poor survival in cancer patients. FOXC2 could be a promising prognostic marker in the future.https://doi.org/10.1177/0300060519891648 |
spellingShingle | Bixia Xu Yun Tian Lin Liu Meta-analysis of the prognostic significance of FOXC2 in various tumors Journal of International Medical Research |
title | Meta-analysis of the prognostic significance of FOXC2 in various tumors |
title_full | Meta-analysis of the prognostic significance of FOXC2 in various tumors |
title_fullStr | Meta-analysis of the prognostic significance of FOXC2 in various tumors |
title_full_unstemmed | Meta-analysis of the prognostic significance of FOXC2 in various tumors |
title_short | Meta-analysis of the prognostic significance of FOXC2 in various tumors |
title_sort | meta analysis of the prognostic significance of foxc2 in various tumors |
url | https://doi.org/10.1177/0300060519891648 |
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