The association of FGF-21 with the risk of newly diagnosed type-2 diabetes mellitus: a cross-sectional study in Southern China
Abstract Background This study investigated the relationship between fibroblast growth factor 21 (FGF-21) and newly diagnosed type-2 diabetes mellitus (T2DM). Methods In this cross-sectional study, FGF-21 and T2DM risk were analyzed using restricted cubic splines with univariate or multivariate logi...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-023-01426-y |
| _version_ | 1797559131931934720 |
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| author | Lili You Xiaosi Hong Hongshi Wu Diefei Liang Feng Li Dinghao Zheng Xiuwei Zhang Dan Liu Qingyu Chen Li Yan Meng Ren Wei Wang |
| author_facet | Lili You Xiaosi Hong Hongshi Wu Diefei Liang Feng Li Dinghao Zheng Xiuwei Zhang Dan Liu Qingyu Chen Li Yan Meng Ren Wei Wang |
| author_sort | Lili You |
| collection | DOAJ |
| description | Abstract Background This study investigated the relationship between fibroblast growth factor 21 (FGF-21) and newly diagnosed type-2 diabetes mellitus (T2DM). Methods In this cross-sectional study, FGF-21 and T2DM risk were analyzed using restricted cubic splines with univariate or multivariate logistic regression analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated via logistic regression analysis. Cluster and subgroup analyses were conducted to evaluate the associations between FGF-21 and diabetes in different subpopulations. Nomograms and ROC curves were used to explore the clinical utility of FGF-21 in the diabetes assessment model. Results High levels of FGF-21 were significantly associated with a high risk of T2DM after adjusting for confounding factors in both the total population and subpopulations (P for trend < 0.001). In the total population, the ORs of diabetes with increasing FGF-21 quartiles were 1.00 (reference), 1.24 (95% CI 0.56–2.80; quartile 2), 2.47 (95% CI 1.18–5.33; quartile 3), and 3.24 (95% CI 1.53–7.14; quartile 4) in Model 4 (P < 0.001), and the trend was consistent in different subpopulations. In addition, compared with the model constructed with conventional noninvasive indicators, the AUC of the model constructed by adding FGF-21 was increased from 0.668 (95% CI: 0.602–0.733) to 0.715 (95% CI: 0.654–0.777), indicating that FGF-21 could significantly improve the risk-assessment efficiency of type-2 diabetes. Conclusion This study demonstrated that a high level of circulating FGF-21 was positively correlated with diabetes, and levels of FGF-21 could be an important biomarker for the assessment of diabetes risk. |
| first_indexed | 2024-03-10T17:41:05Z |
| format | Article |
| id | doaj.art-b91981043bd347dcbc7cdc76b1f95af1 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-03-10T17:41:05Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-b91981043bd347dcbc7cdc76b1f95af12023-11-20T09:42:01ZengBMCBMC Endocrine Disorders1472-68232023-09-0123111110.1186/s12902-023-01426-yThe association of FGF-21 with the risk of newly diagnosed type-2 diabetes mellitus: a cross-sectional study in Southern ChinaLili You0Xiaosi Hong1Hongshi Wu2Diefei Liang3Feng Li4Dinghao Zheng5Xiuwei Zhang6Dan Liu7Qingyu Chen8Li Yan9Meng Ren10Wei Wang11Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Dongguan People’s HospitalDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Medical Examination Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityAbstract Background This study investigated the relationship between fibroblast growth factor 21 (FGF-21) and newly diagnosed type-2 diabetes mellitus (T2DM). Methods In this cross-sectional study, FGF-21 and T2DM risk were analyzed using restricted cubic splines with univariate or multivariate logistic regression analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated via logistic regression analysis. Cluster and subgroup analyses were conducted to evaluate the associations between FGF-21 and diabetes in different subpopulations. Nomograms and ROC curves were used to explore the clinical utility of FGF-21 in the diabetes assessment model. Results High levels of FGF-21 were significantly associated with a high risk of T2DM after adjusting for confounding factors in both the total population and subpopulations (P for trend < 0.001). In the total population, the ORs of diabetes with increasing FGF-21 quartiles were 1.00 (reference), 1.24 (95% CI 0.56–2.80; quartile 2), 2.47 (95% CI 1.18–5.33; quartile 3), and 3.24 (95% CI 1.53–7.14; quartile 4) in Model 4 (P < 0.001), and the trend was consistent in different subpopulations. In addition, compared with the model constructed with conventional noninvasive indicators, the AUC of the model constructed by adding FGF-21 was increased from 0.668 (95% CI: 0.602–0.733) to 0.715 (95% CI: 0.654–0.777), indicating that FGF-21 could significantly improve the risk-assessment efficiency of type-2 diabetes. Conclusion This study demonstrated that a high level of circulating FGF-21 was positively correlated with diabetes, and levels of FGF-21 could be an important biomarker for the assessment of diabetes risk.https://doi.org/10.1186/s12902-023-01426-yType 2 diabetes mellitusFibroblast growth factor 21BiomarkerRisk assessment model |
| spellingShingle | Lili You Xiaosi Hong Hongshi Wu Diefei Liang Feng Li Dinghao Zheng Xiuwei Zhang Dan Liu Qingyu Chen Li Yan Meng Ren Wei Wang The association of FGF-21 with the risk of newly diagnosed type-2 diabetes mellitus: a cross-sectional study in Southern China BMC Endocrine Disorders Type 2 diabetes mellitus Fibroblast growth factor 21 Biomarker Risk assessment model |
| title | The association of FGF-21 with the risk of newly diagnosed type-2 diabetes mellitus: a cross-sectional study in Southern China |
| title_full | The association of FGF-21 with the risk of newly diagnosed type-2 diabetes mellitus: a cross-sectional study in Southern China |
| title_fullStr | The association of FGF-21 with the risk of newly diagnosed type-2 diabetes mellitus: a cross-sectional study in Southern China |
| title_full_unstemmed | The association of FGF-21 with the risk of newly diagnosed type-2 diabetes mellitus: a cross-sectional study in Southern China |
| title_short | The association of FGF-21 with the risk of newly diagnosed type-2 diabetes mellitus: a cross-sectional study in Southern China |
| title_sort | association of fgf 21 with the risk of newly diagnosed type 2 diabetes mellitus a cross sectional study in southern china |
| topic | Type 2 diabetes mellitus Fibroblast growth factor 21 Biomarker Risk assessment model |
| url | https://doi.org/10.1186/s12902-023-01426-y |
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