Macrophage Recognition of Crystals and Nanoparticles
Inhalation of exogenous crystals such as silica, asbestos, and carbon nanotubes can cause lung fibrosis and cancer. Endogenous crystals such as monosodium urate, cholesterol, and hydroxyapatite are associated with pathogenesis of gout, atherosclerosis, and osteoarthritis, respectively. These crystal...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00103/full |
| _version_ | 1818594919597473792 |
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| author | Masafumi Nakayama Masafumi Nakayama |
| author_facet | Masafumi Nakayama Masafumi Nakayama |
| author_sort | Masafumi Nakayama |
| collection | DOAJ |
| description | Inhalation of exogenous crystals such as silica, asbestos, and carbon nanotubes can cause lung fibrosis and cancer. Endogenous crystals such as monosodium urate, cholesterol, and hydroxyapatite are associated with pathogenesis of gout, atherosclerosis, and osteoarthritis, respectively. These crystal-associated-inflammatory diseases are triggered by the macrophage NLRP3 inflammasome activation and cell death. Therefore, it is important to understand how macrophages recognize crystals. However, it is unlikely that macrophages have evolutionally acquired receptors specific for crystals or recently emerged nanoparticles. Several recent studies have reported that some crystal particles are negatively charged and are recognized by scavenger receptor family members in a charge-dependent manner. Alternatively, a model for receptor-independent phagocytosis of crystals has also been proposed. This review focuses on the mechanisms by which macrophages recognize crystals and nanoparticles. |
| first_indexed | 2024-12-16T11:07:46Z |
| format | Article |
| id | doaj.art-b91a579e03ad4ad3bf343df27106cdce |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-16T11:07:46Z |
| publishDate | 2018-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b91a579e03ad4ad3bf343df27106cdce2022-12-21T22:33:48ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-01-01910.3389/fimmu.2018.00103332929Macrophage Recognition of Crystals and NanoparticlesMasafumi Nakayama0Masafumi Nakayama1Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, JapanPRESTO, Japan Science and Technology Agency, Kawaguchi, JapanInhalation of exogenous crystals such as silica, asbestos, and carbon nanotubes can cause lung fibrosis and cancer. Endogenous crystals such as monosodium urate, cholesterol, and hydroxyapatite are associated with pathogenesis of gout, atherosclerosis, and osteoarthritis, respectively. These crystal-associated-inflammatory diseases are triggered by the macrophage NLRP3 inflammasome activation and cell death. Therefore, it is important to understand how macrophages recognize crystals. However, it is unlikely that macrophages have evolutionally acquired receptors specific for crystals or recently emerged nanoparticles. Several recent studies have reported that some crystal particles are negatively charged and are recognized by scavenger receptor family members in a charge-dependent manner. Alternatively, a model for receptor-independent phagocytosis of crystals has also been proposed. This review focuses on the mechanisms by which macrophages recognize crystals and nanoparticles.http://journal.frontiersin.org/article/10.3389/fimmu.2018.00103/fullmacrophagesphagocytosiscrystalsnanoparticlesinflammationscavenger receptors |
| spellingShingle | Masafumi Nakayama Masafumi Nakayama Macrophage Recognition of Crystals and Nanoparticles Frontiers in Immunology macrophages phagocytosis crystals nanoparticles inflammation scavenger receptors |
| title | Macrophage Recognition of Crystals and Nanoparticles |
| title_full | Macrophage Recognition of Crystals and Nanoparticles |
| title_fullStr | Macrophage Recognition of Crystals and Nanoparticles |
| title_full_unstemmed | Macrophage Recognition of Crystals and Nanoparticles |
| title_short | Macrophage Recognition of Crystals and Nanoparticles |
| title_sort | macrophage recognition of crystals and nanoparticles |
| topic | macrophages phagocytosis crystals nanoparticles inflammation scavenger receptors |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00103/full |
| work_keys_str_mv | AT masafuminakayama macrophagerecognitionofcrystalsandnanoparticles AT masafuminakayama macrophagerecognitionofcrystalsandnanoparticles |