Beyond NK cells: the expanding universe of Innate Lymphoid Cells.
For a long time NK cells were thought to be the only immune innate lymphoid population capable of responding to invading pathogens under the influence of changing environmental cues. In the last few years, an increasing amount of evidence has shown that a number of different Innate Lymphoid Cells fo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00282/full |
| _version_ | 1819099855166898176 |
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| author | Marina eCella Hannah eMiller Christina eSong |
| author_facet | Marina eCella Hannah eMiller Christina eSong |
| author_sort | Marina eCella |
| collection | DOAJ |
| description | For a long time NK cells were thought to be the only immune innate lymphoid population capable of responding to invading pathogens under the influence of changing environmental cues. In the last few years, an increasing amount of evidence has shown that a number of different Innate Lymphoid Cells found at mucosal sites rapidly respond to locally produced cytokines in order to establish or maintain homeostasis. ILC populations closely mirror the phenotype of adaptive Thelper subsets in their ability to secrete soluble factors. Early in the immune response, ILCs are responsible for setting the stage to mount an adaptive T cell response appropriate to the incoming insult. Here we review the diversity of ILC subsets and discuss similarities and differences between ILCs and NK cells in function and key transcriptional factors required for their development. |
| first_indexed | 2024-12-22T00:53:30Z |
| format | Article |
| id | doaj.art-b91d66b8d8084742a5177c093eec14e0 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T00:53:30Z |
| publishDate | 2014-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b91d66b8d8084742a5177c093eec14e02022-12-21T18:44:23ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-06-01510.3389/fimmu.2014.0028288895Beyond NK cells: the expanding universe of Innate Lymphoid Cells.Marina eCella0Hannah eMiller1Christina eSong2Washington University School of MedicineWashington University School of MedicineWashington University School of MedicineFor a long time NK cells were thought to be the only immune innate lymphoid population capable of responding to invading pathogens under the influence of changing environmental cues. In the last few years, an increasing amount of evidence has shown that a number of different Innate Lymphoid Cells found at mucosal sites rapidly respond to locally produced cytokines in order to establish or maintain homeostasis. ILC populations closely mirror the phenotype of adaptive Thelper subsets in their ability to secrete soluble factors. Early in the immune response, ILCs are responsible for setting the stage to mount an adaptive T cell response appropriate to the incoming insult. Here we review the diversity of ILC subsets and discuss similarities and differences between ILCs and NK cells in function and key transcriptional factors required for their development.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00282/fullCytokinesIL-22innate lymphoid cellsNKp44mucosal tissues. |
| spellingShingle | Marina eCella Hannah eMiller Christina eSong Beyond NK cells: the expanding universe of Innate Lymphoid Cells. Frontiers in Immunology Cytokines IL-22 innate lymphoid cells NKp44 mucosal tissues. |
| title | Beyond NK cells: the expanding universe of Innate Lymphoid Cells. |
| title_full | Beyond NK cells: the expanding universe of Innate Lymphoid Cells. |
| title_fullStr | Beyond NK cells: the expanding universe of Innate Lymphoid Cells. |
| title_full_unstemmed | Beyond NK cells: the expanding universe of Innate Lymphoid Cells. |
| title_short | Beyond NK cells: the expanding universe of Innate Lymphoid Cells. |
| title_sort | beyond nk cells the expanding universe of innate lymphoid cells |
| topic | Cytokines IL-22 innate lymphoid cells NKp44 mucosal tissues. |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00282/full |
| work_keys_str_mv | AT marinaecella beyondnkcellstheexpandinguniverseofinnatelymphoidcells AT hannahemiller beyondnkcellstheexpandinguniverseofinnatelymphoidcells AT christinaesong beyondnkcellstheexpandinguniverseofinnatelymphoidcells |